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This study was undertaken to investigate the antibody\u2010mediated immune response that leads to SLE skin lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study included 85 SLE patients with lupus\u2010specific skin lesions and 31 without skin lesions. The reactivity of serum antibody with skin antigens was determined by immunoblotting using human foreskin as the substrate. Skin antigens were identified using mass spectrometry. Serum antibody was isolated by affinity purification and was injected intracutaneously into mouse skin to determine pathogenicity. Serum antibody levels were monitored by enzyme\u2010linked immunosorbent assay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We determined that 78% of the patients with skin lesions had serum antibodies reactive with 35\u2010kd and\/or 25\u2010kd skin antigens, which was significantly higher than the percentage of patients without skin lesions (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.0001), suggesting a correlation between immune response and skin lesions. Acidic ribosomal protein P0 (RPLP0) and galectin 3 were 2 target antigens identified from 35\u2010kd and 25\u2010kd proteins, respectively. Purified serum anti\u2010RPLP0 and anti\u2013galectin 3 antibodies induced lupus\u2010like histologic changes after intracutaneous injection. Anti\u2010RPLP0 and anti\u2013galectin 3 antibody levels were significantly higher in SLE patients than in healthy controls and decreased with skin recovery. Anti\u2013galectin 3 antibody levels were not significantly higher in SLE patients than in patients with dermatomyositis or scleroderma, but strongly related to lupus cutaneous vasculitis. Additionally, levels of the 2 antibodies were positively correlated with leukopenia and C3 deficiency, and the anti\u2010RPLP0 antibody level was also positively correlated with arthritis and SLE disease activity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings indicate that the immune response mediated by serum anti\u2010RPLP0 and anti\u2013galectin 3 antibodies plays a key role in the pathogenesis of SLE skin lesions. These findings provide new insights into the mechanism of SLE\u2010related organ disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.38891","type":"journal-article","created":{"date-parts":[[2014,10,10]],"date-time":"2014-10-10T16:44:24Z","timestamp":1412959464000},"page":"193-203","source":"Crossref","is-referenced-by-count":39,"title":["Association of Anti\u2013Acidic Ribosomal Protein P0 and Anti\u2013Galectin 3 Antibodies With the Development of Skin Lesions in Systemic Lupus Erythematosus"],"prefix":"10.1002","volume":"67","author":[{"given":"Zhen\u2010rui","family":"Shi","sequence":"first","affiliation":[{"name":"Sun Yat\u2010sen Memorial Hospital and Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo\u2010zhen","family":"Tan","sequence":"additional","affiliation":[{"name":"Sun Yat\u2010sen Memorial Hospital and Sun Yat\u2010sen University Guangzhou 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