{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T06:09:39Z","timestamp":1793686179158,"version":"4.5.1"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,12,27]],"date-time":"2014-12-27T00:00:00Z","timestamp":1419638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000960","name":"American College of Rheumatology Research and Education Foundation","doi-asserted-by":"publisher","award":["WOR Award"],"award-info":[{"award-number":["WOR Award"]}],"id":[{"id":"10.13039\/100000960","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["1I01BX000788"],"award-info":[{"award-number":["1I01BX000788"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Interstitial lung disease (ILD) is a relatively common extraarticular manifestation of rheumatoid arthritis (RA) that contributes significantly to disease burden and excess mortality. The purpose of this study was to identify peripheral blood markers of RA\u2010associated ILD that can facilitate earlier diagnosis and provide insight regarding the pathogenesis of this potentially devastating disease complication.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with RA who were enrolled in a well\u2010characterized Chinese identification cohort or a US replication cohort were subclassified as having RA\u2013no ILD, RA\u2013mild ILD, or RA\u2013advanced ILD, based on high\u2010resolution computed tomography scans of the chest. Multiplex enzyme\u2010linked immunosorbent assays (ELISAs) and Luminex xMAP technology were used to assess 36 cytokines\/chemokines, matrix metalloproteinases (MMPs), and acute\u2010phase proteins in the identification cohort. Unadjusted and adjusted logistic regression models were used to quantify the strength of association between RA\u2010ILD and biomarkers of interest.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>MMP\u20107 and interferon\u2010\u03b3\u2013inducible protein 10 (IP\u201010)\/CXCL10 were identified by multiplex ELISA as potential biomarkers for RA\u2010ILD in 133 RA patients comprising the Chinese identification cohort (50 RA\u2013no ILD, 41 RA\u2010ILD, 42 RA\u2013indeterminate ILD). The findings were confirmed by standard solid\u2010phase sandwich ELISA in the Chinese identification cohort as well as an independent cohort of US patients with RA and different stages of ILD (22 RA\u2013no ILD, 49 RA\u2010ILD, 15 RA\u2013indeterminate ILD), with statistically significant associations in both unadjusted and adjusted logistic regression analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Levels of MMP\u20107 and IP\u201010\/CXCL10 are elevated in the serum of RA patients with ILD, whether mild or advanced, supporting their value as pathogenically relevant biomarkers that can contribute to noninvasive detection of this extraarticular disease complication.<\/jats:p>\n                  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