{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:32:26Z","timestamp":1791340346313,"version":"4.3.1"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,1,28]],"date-time":"2015-01-28T00:00:00Z","timestamp":1422403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/62329\/2009"],"award-info":[{"award-number":["SFRH\/BD\/62329\/2009"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004342","name":"Wyeth","doi-asserted-by":"publisher","award":["unrestricted grant"],"award-info":[{"award-number":["unrestricted grant"]}],"id":[{"id":"10.13039\/100004342","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The Ankylosing Spondylitis Disease Activity Score (ASDAS) is a composite measure of disease activity in axial spondyloarthritis. The aims of this study were to determine the most appropriate method for calculating the ASDAS using the C\u2010reactive protein (CRP) level when the conventional CRP level was below the limit of detection, to determine how low CRP values obtained by high\u2010sensitivity CRP (hsCRP) measurement influence ASDAS\u2010CRP results, and to test agreement between different ASDAS formulae.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with axial spondyloarthritis who had a conventional CRP level below the limit of detection (5 mg\/liter) were selected (n = 257). The ASDAS\u2013conventional CRP with 11 different imputations for the conventional CRP value (range 0\u20135 mg\/liter, at 0.5\u2010mg\/liter intervals) was calculated. The ASDAS\u2010hsCRP and ASDAS using the erythrocyte sedimentation rate (ESR) were also calculated. Agreement between the ASDAS formulae was tested.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The ASDAS\u2010hsCRP showed better agreement with the ASDAS\u2010CRP calculated using the conventional CRP imputation values of 1.5 and 2.0 mg\/liter and with the ASDAS\u2010ESR than with other imputed formulae. Disagreement occurred mainly in lower disease activity states (inactive\/moderate disease activity). When the CRP value was &lt;2 mg\/liter, the resulting ASDAS\u2010CRP scores may have been inappropriately low.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>When the conventional CRP level is below the limit of detection or when the hsCRP level is &lt;2 mg\/liter, the constant value of 2 mg\/liter should be used to calculate the ASDAS\u2010CRP score. There is good agreement between the ASDAS\u2010hsCRP and ASDAS\u2010ESR; however, formulae are not interchangeable.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.38921","type":"journal-article","created":{"date-parts":[[2014,10,20]],"date-time":"2014-10-20T11:06:15Z","timestamp":1413803175000},"page":"408-413","source":"Crossref","is-referenced-by-count":60,"title":["Brief Report: Calculating the Ankylosing Spondylitis Disease Activity Score If the Conventional C\u2010Reactive Protein Level Is Below the Limit of Detection or If High\u2010Sensitivity C\u2010Reactive Protein Is Used: An Analysis in the DESIR Cohort"],"prefix":"10.1002","volume":"67","author":[{"given":"Pedro","family":"Machado","sequence":"first","affiliation":[{"name":"Leiden University Medical Center Leiden The Netherlands"},{"name":"University of Coimbra Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Navarro\u2010Comp\u00e1n","sequence":"additional","affiliation":[{"name":"Leiden University Medical Center Leiden The Netherlands"},{"name":"University Hospital La Paz Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Landew\u00e9","sequence":"additional","affiliation":[{"name":"Amsterdam Rheumatology Center, Amsterdam, The Netherlands, and Atrium Medical Center Heerlen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floris A.","family":"van Gaalen","sequence":"additional","affiliation":[{"name":"Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Roux","sequence":"additional","affiliation":[{"name":"Paris Descartes University Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9sir\u00e9e","family":"van der Heijde","sequence":"additional","affiliation":[{"name":"Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.094870"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.138594"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.100826"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201999"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.138883"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.110279"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3369"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202976"},{"key":"e_1_2_7_10_1","first-page":"78","article-title":"Ankylosing spondylitis functional and activity indices in clinical practice","volume":"7","author":"Popescu C","year":"2014","journal-title":"J Med Life"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker087"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2011.01.013"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.110767"},{"key":"e_1_2_7_14_1","first-page":"2286","article-title":"A new approach to defining disease status in ankylosing spondylitis: the Bath Ankylosing Spondylitis Disease Activity Index","volume":"21","author":"Garrett S","year":"1994","journal-title":"J Rheumatol"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes057"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reuma.2013.12.006"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2013.93"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.120139"}],"container-title":["Arthritis &amp; 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