{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:32:54Z","timestamp":1791340374579,"version":"4.3.1"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,2,25]],"date-time":"2015-02-25T00:00:00Z","timestamp":1424822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Health and Medical Research Council of Australia"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Ankylosing spondylitis (AS) is a common, highly heritable immune\u2010mediated arthropathy that occurs in genetically susceptible individuals exposed to an unknown but likely ubiquitous environmental trigger. There is a close relationship between the gut and spondyloarthritis, as exemplified in patients with reactive arthritis, in whom a typically self\u2010limiting arthropathy follows either a gastrointestinal or urogenital infection. Microbial involvement in AS has been suggested; however, no definitive link has been established. The aim of this study was to determine whether the gut in patients with AS carries a distinct microbial signature compared with that in the gut of healthy control subjects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Microbial profiles for terminal ileum biopsy specimens obtained from patients with recent\u2010onset tumor necrosis factor antagonist\u2013naive AS and from healthy control subjects were generated using culture\u2010independent 16S ribosomal RNA gene sequencing and analysis techniques.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Our results showed that the terminal ileum microbial communities in patients with AS differ significantly (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001) from those in healthy control subjects, driven by a higher abundance of 5 families of bacteria (\n                      <jats:italic>Lachnospiraceae<\/jats:italic>\n                      [\n                      <jats:italic>P<\/jats:italic>\n                      = 0.001],\n                      <jats:italic>Ruminococcaceae<\/jats:italic>\n                      [\n                      <jats:italic>P<\/jats:italic>\n                      = 0.012],\n                      <jats:italic>Rikenellaceae<\/jats:italic>\n                      [\n                      <jats:italic>P<\/jats:italic>\n                      = 0.004],\n                      <jats:italic>Porphyromonadaceae<\/jats:italic>\n                      [\n                      <jats:italic>P<\/jats:italic>\n                      = 0.001], and\n                      <jats:italic>Bacteroidaceae<\/jats:italic>\n                      [\n                      <jats:italic>P<\/jats:italic>\n                      = 0.001]) and a decrease in the abundance of 2 families of bacteria (\n                      <jats:italic>Veillonellaceae<\/jats:italic>\n                      [\n                      <jats:italic>P<\/jats:italic>\n                      = 0.01] and\n                      <jats:italic>Prevotellaceae<\/jats:italic>\n                      [\n                      <jats:italic>P<\/jats:italic>\n                      = 0.004]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We show evidence for a discrete microbial signature in the terminal ileum of patients with AS compared with healthy control subjects. The microbial composition was demonstrated to correlate with disease status, and greater differences were observed between disease groups than within disease groups. These results are consistent with the hypothesis that genes associated with AS act, at least in part, through effects on the gut microbiome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.38967","type":"journal-article","created":{"date-parts":[[2014,11,21]],"date-time":"2014-11-21T15:21:31Z","timestamp":1416583291000},"page":"686-691","source":"Crossref","is-referenced-by-count":398,"title":["Brief Report: Intestinal Dysbiosis in Ankylosing Spondylitis"],"prefix":"10.1002","volume":"67","author":[{"given":"Mary\u2010Ellen","family":"Costello","sequence":"first","affiliation":[{"name":"University of Queensland Diamantina Institute, Translational Research Institute, and Princess Alexandra Hospital, Woolloongabba, Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Ciccia","sequence":"additional","affiliation":[{"name":"University of Palermo Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Willner","sequence":"additional","affiliation":[{"name":"Australian Centre for Ecogenomics and University of Queensland, Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Warrington","sequence":"additional","affiliation":[{"name":"University of Queensland Diamantina Institute, Translational Research Institute, and Princess Alexandra Hospital, Woolloongabba, Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip C.","family":"Robinson","sequence":"additional","affiliation":[{"name":"University of Queensland Diamantina Institute, Translational Research Institute, and Princess Alexandra Hospital, Woolloongabba, Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brooke","family":"Gardiner","sequence":"additional","affiliation":[{"name":"University of Queensland Diamantina Institute, Translational Research Institute, and Princess Alexandra Hospital, Woolloongabba, Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mhairi","family":"Marshall","sequence":"additional","affiliation":[{"name":"University of Queensland Diamantina Institute, Translational Research Institute, and Princess Alexandra Hospital, Woolloongabba, Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony J.","family":"Kenna","sequence":"additional","affiliation":[{"name":"University of Queensland Diamantina Institute, Translational Research Institute, and Princess Alexandra Hospital, Woolloongabba, Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Triolo","sequence":"additional","affiliation":[{"name":"University of Palermo Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew A.","family":"Brown","sequence":"additional","affiliation":[{"name":"University of Queensland Diamantina Institute, Translational Research Institute, and Princess Alexandra Hospital, Woolloongabba, Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/41.12.1395"},{"key":"e_1_2_7_3_1","first-page":"294","article-title":"HLA\u2010B27 related arthritis and bowel inflammation. Part 2: ileocolonoscopy and bowel histology in patients with HLA\u2010B27 related arthritis","volume":"12","author":"Mielants H","year":"1985","journal-title":"J Rheumatol"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780401015"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2007.17"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3502"},{"key":"e_1_2_7_7_1","first-page":"394","article-title":"Intestinal mucosal permeability in inflammatory rheumatic diseases. II. Role of disease","volume":"18","author":"Mielants H","year":"1991","journal-title":"J Rheumatol"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.32.4.354"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.f.303"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2676"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201209-1680OC"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11225"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/16.3.190"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.04.022"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0105684"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.06.001"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.2217\/ijr.12.84"}],"container-title":["Arthritis &amp; Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.38967","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.38967","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.38967","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T13:41:19Z","timestamp":1759930879000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/art.38967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,25]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1002\/art.38967"],"URL":"https:\/\/doi.org\/10.1002\/art.38967","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725500745.793529571","asserted-by":"object"}]},"ISSN":["2326-5191","2326-5205"],"issn-type":[{"value":"2326-5191","type":"print"},{"value":"2326-5205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,25]]}}}