{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:39:36Z","timestamp":1791308376154,"version":"4.3.1"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,2,25]],"date-time":"2015-02-25T00:00:00Z","timestamp":1424822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Bristol-Myers Squibb"},{"name":"Centocor"},{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100004337","name":"Roche","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004337","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100004339","name":"Sanofi-Aventis","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Schwarz Biosciences"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the impact of tocilizumab treatment on growth and growth\u2010related laboratory parameters in patients with systemic juvenile idiopathic arthritis (JIA) enrolled in a phase III clinical trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with systemic JIA ages 2\u201317 years (n = 112) received tocilizumab in a 12\u2010week, randomized, placebo\u2010controlled period and a long\u2010term open\u2010label extension. Height velocity and standard deviation (SD) score; levels of insulin\u2010like growth factor 1 (IGF\u20101), osteocalcin (OC), and C\u2010telopeptide of type I collagen (CTX\u2010I); and Juvenile Arthritis Disease Activity Score in 71 joints (JADAS\u201071) were measured in a post hoc analysis of 83 patients who never received growth hormone and did not reach Tanner stage 5 by the end of the first year of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients had stunted growth at baseline (mean height SD score \u22122.2). During tocilizumab treatment, males (73%) and females (83%) experienced above\u2010normal mean height velocities of 6.6 cm\/year (<jats:italic>P<\/jats:italic> &lt; 0.0001 versus World Health Organization norms). Mean height SD score increases during year 1 (0.29) and year 2 (0.31) were significant (both <jats:italic>P<\/jats:italic> &lt; 0.0001). The mean SD score for IGF\u20101 levels increased significantly (\u22120.2 for year 1 and \u22120.1 for year 2 versus \u22121.0 at baseline; both <jats:italic>P<\/jats:italic> &lt; 0.0001). Mean OC and CTX\u2010I levels (both <jats:italic>P<\/jats:italic> &lt; 0.0001) and the OC:CTX\u2010I ratio (<jats:italic>P<\/jats:italic> = 0.014) significantly increased from baseline to year 2. In multiple regression analysis, first\u2010year height velocity had a significant inverse relationship to JADAS\u201071 at year 1, age, mean glucocorticoid dosage during the year, and height SD score at baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings indicate that during treatment with tocilizumab, patients with systemic JIA experience significant catch\u2010up growth, normalization of IGF\u20101 levels, and bone balance improvement favoring bone formation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.38984","type":"journal-article","created":{"date-parts":[[2014,12,10]],"date-time":"2014-12-10T10:23:22Z","timestamp":1418207002000},"page":"840-848","source":"Crossref","is-referenced-by-count":74,"title":["Catch\u2010Up Growth During Tocilizumab Therapy for Systemic Juvenile Idiopathic Arthritis: Results From a Phase III Trial"],"prefix":"10.1002","volume":"67","author":[{"given":"Fabrizio","family":"De Benedetti","sequence":"first","affiliation":[{"name":"IRCCS Ospedale Pediatrico Bambino Ges\u00f9 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermine","family":"Brunner","sequence":"additional","affiliation":[{"name":"University of Cincinnati and Cincinnati Children's Hospital Medical Center Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolino","family":"Ruperto","sequence":"additional","affiliation":[{"name":"Istituto Giannina Gaslini Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rayfel","family":"Schneider","sequence":"additional","affiliation":[{"name":"Hospital for Sick Children and University of Toronto, Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Xavier","sequence":"additional","affiliation":[{"name":"Hospital de Clinicas de Porto Alegre and Universidade Federal do Rio Grande do Sul Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Allen","sequence":"additional","affiliation":[{"name":"Royal Children's Hospital, Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane E.","family":"Brown","sequence":"additional","affiliation":[{"name":"Children's Hospital of Los Angeles and University of Southern California Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Chaitow","sequence":"additional","affiliation":[{"name":"Children's Hospital Westmead, Westmead New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Pardeo","sequence":"additional","affiliation":[{"name":"IRCCS Ospedale Pediatrico Bambino Ges\u00f9 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graciela","family":"Espada","sequence":"additional","affiliation":[{"name":"Hospital de Ni\u00f1os Ricardo Gutierrez Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Gerloni","sequence":"additional","affiliation":[{"name":"Istituto Gaetano Pini Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry L.","family":"Myones","sequence":"additional","affiliation":[{"name":"Texas Children's Hospital and Baylor College of Medicine Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James W.","family":"Frane","sequence":"additional","affiliation":[{"name":"Genentech South San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianmei","family":"Wang","sequence":"additional","affiliation":[{"name":"Roche Products Ltd. 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