{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:57:00Z","timestamp":1759971420824,"version":"build-2065373602"},"reference-count":6,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,2,25]],"date-time":"2015-02-25T00:00:00Z","timestamp":1424822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis & Rheumatology"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1002\/art.38992","type":"journal-article","created":{"date-parts":[[2014,12,15]],"date-time":"2014-12-15T09:58:25Z","timestamp":1418637505000},"page":"857-858","source":"Crossref","is-referenced-by-count":2,"title":["Half\u2010Life and Safety of Canakinumab in Pediatric Patients: Comment on the Article by Ilowite et al"],"prefix":"10.1002","volume":"67","author":[{"given":"Hermine","family":"Brunner","sequence":"first","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center Cincinnati OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen Graham","family":"Lomax","sequence":"additional","affiliation":[{"name":"Novartis Pharmaceuticals Corporation East Hanover NJ"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephane","family":"Levy","sequence":"additional","affiliation":[{"name":"Novartis Pharmaceuticals Corporation East Hanover NJ"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2,25]]},"reference":[{"key":"e_1_2_2_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38699"},{"volume-title":"Ilaris (canakinumab) prescribing information","year":"2014","key":"e_1_2_2_2_1"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400703"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1205099"},{"key":"e_1_2_2_5_1","unstructured":"Novartis Pharmaceuticals and Pediatric Rheumatology International Trials Organization. Flare prevention study of canakinumab in patients with active systemic juvenile idiopathic arthritis (SJIA) (\u03b2\u2010SPECIFIC 2). URL:http:\/\/www.clinicaltrials.gov\/ct2\/show\/study\/NCT00889863."},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-eular.1215"}],"container-title":["Arthritis & Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.38992","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.38992","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.38992","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T13:41:38Z","timestamp":1759930898000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/art.38992"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,25]]},"references-count":6,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1002\/art.38992"],"URL":"https:\/\/doi.org\/10.1002\/art.38992","archive":["Portico"],"relation":{},"ISSN":["2326-5191","2326-5205"],"issn-type":[{"type":"print","value":"2326-5191"},{"type":"electronic","value":"2326-5205"}],"subject":[],"published":{"date-parts":[[2015,2,25]]}}}