{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T07:50:45Z","timestamp":1791618645535,"version":"4.3.4"},"reference-count":51,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,3,27]],"date-time":"2015-03-27T00:00:00Z","timestamp":1427414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Among autoimmune diseases, Sj\u00f6gren's syndrome (SS) is most strongly associated with the development of malignant B cell lymphoma, in particular mucosa\u2010associated lymphoid tissue (MALT)\u2013type lymphoma. Previously, we have shown that in \u223c40% of cases of salivary gland MALT lymphoma, high\u2010affinity stereotypic rheumatoid factor (RF) B cell receptors, specific for IgG\u2010Fc, are expressed. This study was undertaken to investigate whether in the inflamed salivary glands of patients with SS, a similar RF\u2010biased Ig repertoire is present.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Extensive analyses of the B cell Ig V<jats:sub>H<\/jats:sub> region repertoire were performed on microdissected tissue samples from the labial salivary glands of 4 patients with SS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All SS labial salivary glands harbored expanded B cell clones, of which 1 or 2 were highly expanded and detected in &gt;50% of the microdissected samples. However, among the identified 464 distinct Ig clonotypes, only 3 stereotypic RF\u2013expressing clones were detected. In 2 patients with SS, an RF\u2010expressing clone was detected at low frequency in 1 of the microdissected samples, whereas 1 patient with SS harbored a highly expanded RF\u2010expressing clone that was detected in all microdissected samples and also detected in the peripheral blood. Two years after analysis of this sample, the latter patient developed a diffuse large B cell lymphoma originating from the same RF clone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Inflamed labial salivary glands in patients with SS generally harbor 1 or 2 highly expanded B cell clones. The repertoire strongly biased toward stereotypic RFs in salivary gland MALT lymphomas is not a reflection of a similar repertoire in the inflamed salivary glands of patients with SS; rather, in the latter, the repertoire is based on a strong selection advantage of incidental stereotypic RF\u2013expressing B cells.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.39002","type":"journal-article","created":{"date-parts":[[2014,12,29]],"date-time":"2014-12-29T11:04:58Z","timestamp":1419851098000},"page":"1074-1083","source":"Crossref","is-referenced-by-count":41,"title":["Stereotypic Rheumatoid Factors That Are Frequently Expressed in Mucosa\u2010Associated Lymphoid Tissue\u2013Type Lymphomas Are Rare in the Labial Salivary Glands of Patients With Sj\u00f6gren's Syndrome"],"prefix":"10.1002","volume":"67","author":[{"given":"Richard J.","family":"Bende","sequence":"first","affiliation":[{"name":"Academic Medical Center and University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda M.","family":"Slot","sequence":"additional","affiliation":[{"name":"Academic Medical Center and University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robbert","family":"Hoogeboom","sequence":"additional","affiliation":[{"name":"Academic Medical Center and University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thera A. 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