{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:03:24Z","timestamp":1792782204747,"version":"4.5.0"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,3,27]],"date-time":"2015-03-27T00:00:00Z","timestamp":1427414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["AR061439"],"award-info":[{"award-number":["AR061439"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001845","name":"Scleroderma Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001845","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Catherine Keilty Memorial Fund for Scleroderma Research"},{"name":"Donald and Dorothy Stabler Foundation","id":[{"id":"https:\/\/ror.org\/03e6q8t78","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We previously reported a contemporaneous onset of cancer and scleroderma in patients with anti\u2013RNA polymerase III antibodies, and we identified a biologic link between cancer and scleroderma. This investigation was designed to further evaluate whether autoantibody status and other characteristics are associated with cancer and a clustering of cancer with scleroderma onset.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Logistic regression analysis was performed to assess the relationship of 2 outcomes, cancer (model 1) and a short (\u00b12 years) cancer\u2013scleroderma interval (model 2), with autoantibody status and scleroderma covariates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 1,044 scleroderma patients, 168 (16.1%) had cancer. In the adjusted model 1, only older age at scleroderma onset (odds ratio 1.04 [95% confidence interval 1.02\u20131.05]) and white race (odds ratio 2.71 [95% confidence interval 1.22\u20136.04]) were significantly associated with an increased overall risk of cancer. In the adjusted model 2, only anti\u2013RNA polymerase III positivity (odds ratio 5.08 [95% confidence interval 1.60\u201316.1]) and older age at scleroderma onset (odds ratio 1.04 [95% confidence interval 1.00\u20131.08]) were significantly associated with a short cancer\u2013scleroderma interval. While anti\u2013RNA polymerase III positivity was associated with a short cancer\u2013scleroderma interval independent of age at scleroderma onset, the cancer\u2013scleroderma interval shortened with older age at scleroderma onset in other antibody groups (Spearman's correlation\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05), particularly among patients with anti\u2013topoisomerase I antibodies and patients who were negative for anticentromere, anti\u2013topoisomerase I, and anti\u2013RNA polymerase III antibodies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Increased age at scleroderma onset is strongly associated with cancer risk overall. While anti\u2013RNA polymerase III status is an independent marker of coincident cancer and scleroderma at any age, a clustering of cancer with scleroderma is also seen in patients with anti\u2013topoisomerase I and other autoantibody specificities who develop scleroderma at older ages.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.39022","type":"journal-article","created":{"date-parts":[[2015,1,20]],"date-time":"2015-01-20T13:02:27Z","timestamp":1421758947000},"page":"1053-1061","source":"Crossref","is-referenced-by-count":114,"title":["Examination of Autoantibody Status and Clinical Features Associated With Cancer Risk and Cancer\u2010Associated Scleroderma"],"prefix":"10.1002","volume":"67","author":[{"given":"Ami A.","family":"Shah","sequence":"first","affiliation":[{"name":"Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura K.","family":"Hummers","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia","family":"Casciola\u2010Rosen","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kala","family":"Visvanathan","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine and Johns Hopkins Bloomberg School of Public Health Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antony","family":"Rosen","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrick M.","family":"Wigley","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09861.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-134-12-200106190-00008"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03540-6"},{"key":"e_1_2_7_5_1","first-page":"1855","article-title":"The overall and temporal association of cancer with polymyositis and dermatomyositis","volume":"21","author":"Zantos D","year":"1994","journal-title":"J Rheumatol"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-004-0940-5"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-008-0540-9"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27549"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.101144"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3544"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar4486"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1246886"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230510"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2007.12.001"},{"key":"e_1_2_7_15_1","first-page":"202","article-title":"Scleroderma (systemic sclerosis): classification, subsets and pathogenesis","volume":"15","author":"LeRoy EC","year":"1988","journal-title":"J Rheumatol"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.1.9712108"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1987.135.4.805"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh067"},{"key":"e_1_2_7_19_1","first-page":"2159","article-title":"A disease severity scale for systemic sclerosis: development and testing","volume":"26","author":"Medsger TA","year":"1999","journal-title":"J Rheumatol"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38093"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e32834a5081"}],"container-title":["Arthritis &amp; 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