{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:02:51Z","timestamp":1792782171319,"version":"4.5.0"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T00:00:00Z","timestamp":1430092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007338","name":"Barnes-Jewish Hospital Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007338","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Center for Human Immunology and Immunotherapy Programs at Washington University"},{"name":"NIH","award":["P30-AR-048335"],"award-info":[{"award-number":["P30-AR-048335"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Chikungunya virus (CHIKV) is an arthritogenic mosquito\u2010transmitted alphavirus that spread to the Caribbean in 2013 and to the US in 2014. CHIKV\u2010infected patients develop inflammatory arthritis that can persist for months or years, but little is known about the rheumatologic and immunologic features of CHIKV\u2010related arthritis in humans, particularly as compared to rheumatoid arthritis (RA). The purpose of this study was to describe these features in a group of 10 American travelers who were nearly simultaneously infected while visiting Haiti in June 2014.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patient history was obtained and physical examination and laboratory tests were performed. All patients with CHIKV\u2010related arthritis had detectable levels of anti\u2010CHIKV IgG. Using cytometry by time\u2010of\u2010flight (CyTOF), we analyzed peripheral blood mononuclear cells in CHIKV\u2010infected patients, healthy controls, and patients with untreated, active RA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 10 CHIKV\u2010infected individuals, 8 developed persistent symmetric polyarthritis that met the American College of Rheumatology\/European League Against Rheumatism 2010 criteria for (seronegative) RA. CyTOF analysis revealed that RA and CHIKV\u2010infected patients had greater percentages of activated and effector CD4+ and CD8+ T cells than healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In addition to similar clinical features, patients with CHIKV infection and patients with RA develop very similar peripheral T cell phenotypes. These overlapping clinical and immunologic features highlight a need for rheumatologists to consider CHIKV infection when evaluating patients with new, symmetric polyarthritis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.39027","type":"journal-article","created":{"date-parts":[[2015,1,20]],"date-time":"2015-01-20T13:06:10Z","timestamp":1421759170000},"page":"1214-1220","source":"Crossref","is-referenced-by-count":161,"title":["Brief Report: Chikungunya Viral Arthritis in the United States: A Mimic of Seronegative Rheumatoid Arthritis"],"prefix":"10.1002","volume":"67","author":[{"given":"Jonathan J.","family":"Miner","sequence":"first","affiliation":[{"name":"Washington University School of Medicine St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han Xian","family":"Aw Yeang","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie M.","family":"Fox","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Taffner","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga N.","family":"Malkova","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen T.","family":"Oh","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred H. J.","family":"Kim","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Diamond","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah J.","family":"Lenschow","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne M.","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Chevy Chase, Maryland, and Washington University School of Medicine St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400044442"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.2008\/005413-0"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/605496"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.344.6185.678"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.9916"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0030201"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1086\/521911"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002137"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900255"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2010.01.011"},{"key":"e_1_2_7_12_1","first-page":"500","article-title":"Notes from the field: chikungunya virus spreads in the Americas\u2014Caribbean and South America, 2013\u20132014","volume":"6","author":"Fischer M","year":"2014","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003312"},{"key":"e_1_2_7_14_1","first-page":"2569","article-title":"2010 rheumatoid arthritis classification criteria: an American College of Rheumatology\/European League Against Rheumatism collaborative initiative","volume":"62","author":"Aletaha D","journal-title":"Arthritis Rheum 2010;"},{"key":"e_1_2_7_15_1","first-page":"319","article-title":"Effectiveness of chloroquine and inflammatory cytokine response in patients with early persistent musculoskeletal pain and arthritis following chikungunya virus infection. Arthritis","volume":"66","author":"Chopra A","year":"2014","journal-title":"Rheumatol"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI40104"}],"container-title":["Arthritis &amp; Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.39027","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.39027","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.39027","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T12:02:14Z","timestamp":1759924934000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/art.39027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,27]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1002\/art.39027"],"URL":"https:\/\/doi.org\/10.1002\/art.39027","archive":["Portico"],"relation":{},"ISSN":["2326-5191","2326-5205"],"issn-type":[{"value":"2326-5191","type":"print"},{"value":"2326-5205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,27]]}}}