{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:32:26Z","timestamp":1789014746849,"version":"build-2803163510"},"reference-count":56,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T00:00:00Z","timestamp":1430092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"INSERM\/Merck Sharp & Dohme-Chibret, France"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the association of disc degeneration with all\u2010cause mortality and with the severity and rate of progression of abdominal aortic calcification (AAC) in older men.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Men &gt;50 years of age (n\u2009=\u2009766) underwent lateral spine radiography and blood collection and were monitored prospectively. We assessed the association of disc degeneration with all\u2010cause mortality (at 10 years), AAC severity (at baseline), and AAC progression (at 7.5 years).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After adjustment for confounders, including AAC, the total overall grade score for AAC predicted all\u2010cause mortality (hazard ratio [HR] 1.20 per SD increase [95% confidence interval (95% CI) 1.01\u20131.43]). The highest tertile of the total overall grade score was associated with higher mortality rates (39.3\/1,000 person\u2010years for a score of &gt;8 versus 20.9\/1,000 person\u2010years for a score of 0\u20138; adjusted HR 1.47 [95% CI 1.05\u20132.06]). The odds of severe AAC (score of &gt;5) increased with the total disc space narrowing score (adjusted HR 1.44 per SD [95% CI 1.11\u20131.87]). The highest tertile of the total disc space narrowing score was associated with higher odds of severe AAC (adjusted HR 2.42 versus the lowest tertile [95% CI 1.24\u20134.73]). The probability of long\u2010term AAC stability decreased with an increasing total osteophyte score (adjusted HR 0.66 per SD [95% CI 0.49\u20130.88]). The highest tertile of the total osteophyte score was associated with a lower probability of AAC stability (adjusted HR 0.35 versus the lowest tertile [95% CI 0.18\u20130.71]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Older men with severe disc dege\u2010neration have greater AAC severity, faster AAC progression, and higher all\u2010cause mortality rates.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.39055","type":"journal-article","created":{"date-parts":[[2015,3,13]],"date-time":"2015-03-13T12:36:43Z","timestamp":1426250203000},"page":"1295-1304","source":"Crossref","is-referenced-by-count":22,"title":["Association of Severe Disc Degeneration With All\u2010Cause Mortality and Abdominal Aortic Calcification Assessed Prospectively in Older Men: Findings of a Single\u2010Center Prospective Study of Osteoporosis in 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