{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:13:13Z","timestamp":1789996393872,"version":"4.0.1"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,6,26]],"date-time":"2015-06-26T00:00:00Z","timestamp":1435276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH","award":["National Institute on Aging grants R01-AG-5407"],"award-info":[{"award-number":["National Institute on Aging grants R01-AG-5407"]}]},{"name":"NIH","award":["R01-AR-5582"],"award-info":[{"award-number":["R01-AR-5582"]}]},{"name":"NIH","award":["R01-AR-5583"],"award-info":[{"award-number":["R01-AR-5583"]}]},{"name":"NIH","award":["R01-AR-5584"],"award-info":[{"award-number":["R01-AR-5584"]}]},{"name":"NIH","award":["R01-AG-5394"],"award-info":[{"award-number":["R01-AG-5394"]}]},{"name":"NIH","award":["R01-AG-7574"],"award-info":[{"award-number":["R01-AG-7574"]}]},{"name":"NIH","award":["K24-AR-8841"],"award-info":[{"award-number":["K24-AR-8841"]}]},{"name":"NIH","award":["AR-052000"],"award-info":[{"award-number":["AR-052000"]}]},{"name":"NIH","award":["P50-AR-0752"],"award-info":[{"award-number":["P50-AR-0752"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the risk of all\u2010cause and disease\u2010specific mortality among older women with hip osteoarthritis (OA) and to identify mediators in the causal pathway.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were from the Study of Osteoporotic Fractures, a US population\u2010based cohort study of 9,704 white women age \u226565 years. The analytic sample included women with hip radiographs at baseline (n\u2009=\u20097,889) and year 8 (n\u2009=\u20095,749). Mortality was confirmed through October 2013 by death certificates and hospital discharge summaries. Radiographic hip OA (RHOA) was defined as a Croft grade of \u22652 in at least 1 hip (definite joint space narrowing or osteophytes plus 1 other radiographic feature).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean\u2009\u00b1\u2009SD followup time was 16.1\u2009\u00b1 6.2 years. The baseline and year 8 prevalence of RHOA were 8.0% and 11.0%, respectively. The cumulative incidence (proportion of deaths during the study period) was 67.7% for all\u2010cause mortality, 26.3% for cardiovascular disease (CVD) mortality, 11.7% for cancer mortality, 1.9% for gastrointestinal disease mortality, and 27.8% for all other mortality causes. RHOA was associated with an increased risk of all\u2010cause mortality (hazard ratio 1.14 [95% confidence interval 1.05\u20131.24]) and CVD mortality (hazard ratio 1.24 [95% confidence interval 1.09\u20131.41]) adjusted for age, body mass index, education, smoking, health status, diabetes, and stroke. These associations were partially explained by the mediating variable of physical function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>RHOA was associated with an increased risk of all\u2010cause and CVD mortality among older white women followed up for 16 years. Dissemination of evidence\u2010based physical activity and self\u2010management interventions for hip OA in community and clinical settings can improve physical function and might also contribute to lower mortality.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.39113","type":"journal-article","created":{"date-parts":[[2015,3,16]],"date-time":"2015-03-16T18:56:18Z","timestamp":1426532178000},"page":"1798-1805","source":"Crossref","is-referenced-by-count":84,"title":["Hip Osteoarthritis and the Risk of All\u2010Cause and Disease\u2010Specific Mortality in Older Women: A Population\u2010Based Cohort Study"],"prefix":"10.1002","volume":"67","author":[{"given":"Kamil E.","family":"Barbour","sequence":"first","affiliation":[{"name":"CDC Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Yung","family":"Lui","sequence":"additional","affiliation":[{"name":"California Pacific Medical Center San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Nevitt","sequence":"additional","affiliation":[{"name":"University of California San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise B.","family":"Murphy","sequence":"additional","affiliation":[{"name":"CDC Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles G.","family":"Helmick","sequence":"additional","affiliation":[{"name":"CDC Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina A.","family":"Theis","sequence":"additional","affiliation":[{"name":"CDC Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc C.","family":"Hochberg","sequence":"additional","affiliation":[{"name":"University of Maryland School of Medicine Baltimore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy E.","family":"Lane","sequence":"additional","affiliation":[{"name":"University of California at Davis School of Medicine Sacramento"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer M.","family":"Hootman","sequence":"additional","affiliation":[{"name":"CDC Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane A.","family":"Cauley","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Pittsburgh Pennsylvania."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Study of Osteoporotic Fractures Research Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23176"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.007526"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203789"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d1165"},{"issue":"51","key":"e_1_2_6_6_1","first-page":"S120","article-title":"Mortality in osteoarthritis","volume":"26","author":"Hochberg M.","year":"2008","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.080677"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27241"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380706"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23525"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199503233321202"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2008.01807.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115687"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.16.4.494"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199905)42:5<854::AID-ANR3>3.0.CO;2-I"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20213"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24382"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1994.tb06581.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.2307\/2532940"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602102"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021423"},{"key":"e_1_2_6_22_1","first-page":"1","article-title":"Deaths: final data for 2010","volume":"61","author":"Murphy SL","year":"2013","journal-title":"Natl Vital Stat Rep"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwr525"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.93B2.25629"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.D.02440"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30562"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.167.22.2453"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20347"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.2307\/2955359"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.5888\/pcd10.120112"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009567"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22092"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204388"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.17.2018"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/1759720X12467868"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0316"},{"key":"e_1_2_6_37_1","first-page":"1823","article-title":"Deaths from arthritis and other rheumatic conditions, United States, 1979\u20101998","volume":"31","author":"Sacks JJ","year":"2004","journal-title":"J Rheumatol"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60900-9"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.323.7314.662"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.323.7314.662"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1923"}],"container-title":["Arthritis &amp; Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.39113","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.39113","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.39113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T11:29:23Z","timestamp":1759922963000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/art.39113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,26]]},"references-count":40,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1002\/art.39113"],"URL":"https:\/\/doi.org\/10.1002\/art.39113","archive":["Portico"],"relation":{},"ISSN":["2326-5191","2326-5205"],"issn-type":[{"value":"2326-5191","type":"print"},{"value":"2326-5205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,26]]}}}