{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T06:48:34Z","timestamp":1789886914126,"version":"4.0.1"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,6,26]],"date-time":"2015-06-26T00:00:00Z","timestamp":1435276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"South-Eastern Regional Health Authority of Norway"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Patients with rheumatoid arthritis (RA) and carotid artery plaques have an increased risk of acute coronary syndromes. Statin treatment with the goal of achieving a low\u2010density lipoprotein (LDL) cholesterol level of \u22641.8 mmoles\/liter (\u226470 mg\/dl) is recommended for individuals in the general population who have carotid plaques. The aim of the ROsuvastatin in Rheumatoid Arthritis, Ankylosing Spondylitis and other inflammatory joint diseases (RORA\u2010AS) study was to evaluate the effect of 18 months of intensive lipid\u2010lowering treatment with rosuvastatin with regard to change in carotid plaque height.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighty\u2010six patients (60.5% of whom were female) with carotid plaques and inflammatory joint disease (55 with RA, 21 with AS, and 10 with psoriatic arthritis) were treated with rosuvastatin to obtain the LDL cholesterol goal. Carotid plaque height was evaluated by B\u2010mode ultrasonography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean\u2009\u00b1\u2009SD age of the patients was 60.8\u2009\u00b1\u20098.5 years, and the median compliance with rosuvastatin treatment was 97.9% (interquartile range [IQR] 96.0\u201399.4). At baseline, the median number and height of the carotid plaques were 1.0 (range 1\u20138) and 1.80 mm (IQR 1.60\u20132.10), respectively. The mean\u2009\u00b1\u2009SD change in carotid plaque height after 18 months of treatment with rosuvastatin was \u22120.19\u2009\u00b1\u20090.35 mm (<jats:italic>P<\/jats:italic> &lt; 0.0001). The mean\u2009\u00b1\u2009SD baseline LDL cholesterol level was 4.0\u2009\u00b1\u20090.9 mmoles\/liter (154.7\u2009\u00b1\u200934.8 mg\/dl), and the mean reduction in the LDL cholesterol level was \u22122.3 mmoles\/liter (95% confidence interval [95% CI] \u22122.48, \u22122.15) (\u221288.9 mg\/dl [95% CI \u221295.9, \u221283.1]). The mean \u00b1 SD LDL cholesterol level during the 18 months of rosuvastatin treatment was 1.7\u2009\u00b1\u20090.4 mmoles\/liter (area under the curve). After adjustment for age\/sex\/blood pressure, no linear relationship between a reduction in carotid plaque height and the level of LDL cholesterol exposure during the study period was observed. Attainment of the LDL cholesterol goal of \u22641.8 mmoles\/liter (\u226470 mg\/dl) or the amount of change in the LDL cholesterol level during the study period did not influence the degree of carotid plaque height reduction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Intensive lipid\u2010lowering treatment with rosuvastatin induced atherosclerotic regression and reduced the LDL cholesterol level significantly in patients with inflammatory joint disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.39114","type":"journal-article","created":{"date-parts":[[2015,3,16]],"date-time":"2015-03-16T18:56:27Z","timestamp":1426532187000},"page":"1718-1728","source":"Crossref","is-referenced-by-count":55,"title":["Rosuvastatin\u2010Induced Carotid Plaque Regression in Patients With Inflammatory Joint Diseases: The Rosuvastatin in Rheumatoid Arthritis, Ankylosing Spondylitis and Other Inflammatory Joint Diseases Study"],"prefix":"10.1002","volume":"67","author":[{"given":"S.","family":"Rollefstad","sequence":"first","affiliation":[{"name":"Diakonhjemmet Hospital Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Ikdahl","sequence":"additional","affiliation":[{"name":"Diakonhjemmet Hospital Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Hisdal","sequence":"additional","affiliation":[{"name":"Oslo University Hospital Aker Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. 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