{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:27:44Z","timestamp":1791412064221,"version":"4.3.3"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,6,26]],"date-time":"2015-06-26T00:00:00Z","timestamp":1435276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100011102","name":"European Union Seventh Framework Programme","doi-asserted-by":"crossref","award":["FP7\/2007-2013"],"award-info":[{"award-number":["FP7\/2007-2013"]}],"id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100011102","name":"European Union Seventh Framework Programme","doi-asserted-by":"crossref","award":["215009"],"award-info":[{"award-number":["215009"]}],"id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005413","name":"Universit\u00e9 Paris Descartes","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005413","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Assistance Publique-H\u00f4pitaux de Paris AP-HP"},{"name":"RedCat"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Endothelial cell (EC) damage in systemic sclerosis (SSc) is reflected by the shedding of microparticles (MPs). The aim of this study was to show that inhibiting MP release using pantethine or by inactivating ATP\u2010binding cassette transporter A1 (ABCA1) ameliorates murine SSc.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>First, the effects of pantethine on MP shedding and on basal oxidative and nitrosative stresses in ECs and fibroblasts were determined in vitro. The effects of pantethine were then tested in vivo. SSc was induced in BALB\/c mice by daily intradermal injection of HOCl. Mice were simultaneously treated daily with pantethine by oral gavage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In vitro, pantethine inhibited MP shedding from tumor necrosis factor\u2013stimulated ECs and abrogated MP\u2010induced oxidative and nitrosative stresses in ECs and fibroblasts. Ex vivo, pantethine also restored redox homeostasis in fibroblasts from mice with SSc. In vivo, mice with SSc displayed skin and lung fibrosis associated with increased levels of circulating MPs and markers of oxidative and endothelial stress, which were normalized by administration of pantethine or inactivation of\n                      <jats:italic>ABCA1<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Pantethine is a well\u2010tolerated molecule that represents a potential treatment of human SSc.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.39121","type":"journal-article","created":{"date-parts":[[2015,3,16]],"date-time":"2015-03-16T18:57:32Z","timestamp":1426532252000},"page":"1881-1890","source":"Crossref","is-referenced-by-count":48,"title":["Pantethine Prevents Murine Systemic Sclerosis Through the Inhibition of Microparticle Shedding"],"prefix":"10.1002","volume":"67","author":[{"given":"Niloufar","family":"Kavian","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris\u2010Cit\u00e9, Institut Cochin, INSERM U1016, and H\u00f4pital Cochin, AP\u2010HP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wioleta","family":"Marut","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris\u2010Cit\u00e9, Institut Cochin, INSERM U1016, and H\u00f4pital Cochin, AP\u2010HP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00e9lie","family":"Servettaz","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris\u2010Cit\u00e9, Institut Cochin, INSERM U1016, and H\u00f4pital Cochin, AP\u2010HP, Paris, France, and H\u00f4pital Robert Debr\u00e9 Reims 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