{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T12:11:16Z","timestamp":1759925476873,"version":"build-2065373602"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,6,26]],"date-time":"2015-06-26T00:00:00Z","timestamp":1435276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Research Grants Council of the Hong Kong Special Administrative Region, China","award":["SEG CUHK_02","CUHK 473012"],"award-info":[{"award-number":["SEG CUHK_02","CUHK 473012"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate a computer\u2010aided approach to the assessment of spinal inflammation on magnetic resonance imaging (MRI) in spondyloarthritis as compared to visual assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Following institutional ethics approval, 32 patients (mean\u2009\u00b1\u2009SD age 35.3\u2009\u00b1\u200910.2 years) with active ankylosing spondylitis underwent treatment with methotrexate and infliximab for 30 weeks. Spinal MRI examination (T1\u2010weighted, T2\u2010weighted fat\u2010suppressed, and postcontrast T1\u2010weighted fat\u2010suppressed sagittal sequences using a 1.5T MRI system) was performed at baseline and at 30 weeks. Following manual identification of the vertebral corners, vertebral body segmentation was performed using a deformable model that automatically isolated the 4 vertebral corner areas, allowing automatic measurement of the relative mean corner intensity of each vertebral corner before and after treatment. Quantitative computer\u2010aided assessment of spinal inflammation was compared with a semiquantitative visual assessment of spinal inflammation (the Berlin method).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Computer\u2010aided quantification was quick and highly reliable, and it identified increases in vertebral corner edema or enhancement that were significantly decreased following treatment (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.5). For computer\u2010aided analysis, there was excellent inter\u2010 and intrarater correlation of both corner edema and enhancement (intraclass correlation coefficients [ICCs] &gt;0.99), and the correlations were better than those for visual analysis (ICCs 0.83\u20130.96). For computer\u2010aided analysis, the standardized response mean was 1.67 for corner edema and 1.64 for enhancement, as compared to 1.20 and 1.18, respectively, for visual analysis. Computer\u2010aided quantification of MRI data correlated better (r\u2009=\u20090.50\u20130.53, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) with clinical features of spinal disease activity pre\u2010 and posttreatment than did visual analysis of spinal inflammation (r\u2009=\u20090.37\u20130.43, <jats:italic>P<\/jats:italic>\u2009&gt;\u20090.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Computer\u2010aided assessment of spinal inflammation in spondyloarthritis is quick, reliable, and sensitive and correlates better with clinical disease activity than does visual assessment by the Berlin method.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.39126","type":"journal-article","created":{"date-parts":[[2015,3,25]],"date-time":"2015-03-25T11:19:59Z","timestamp":1427282399000},"page":"1789-1797","source":"Crossref","is-referenced-by-count":3,"title":["Computer\u2010Aided Assessment of Spinal Inflammation on Magnetic Resonance Images in Patients With Spondyloarthritis"],"prefix":"10.1002","volume":"67","author":[{"given":"James F.","family":"Griffith","sequence":"first","affiliation":[{"name":"Chinese University of Hong Kong Shatin Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Defeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Chinese University of Hong Kong Shatin Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Shi","sequence":"additional","affiliation":[{"name":"Chinese University of Hong Kong Shatin Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David K. W.","family":"Yeung","sequence":"additional","affiliation":[{"name":"Chinese University of Hong Kong Shatin Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Lee","sequence":"additional","affiliation":[{"name":"Chinese University of Hong Kong Shatin Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tam Lai","family":"Shan","sequence":"additional","affiliation":[{"name":"Chinese University of Hong Kong Shatin Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08215-6"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e328339381e"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e31820f8c59"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.140541"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.104018"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2010.160"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/29661937"},{"key":"e_1_2_6_9_1","first-page":"862","article-title":"Scoring inflammatory activity of the spine by magnetic resonance imaging in ankylosing spondylitis: a multireader experiment","volume":"34","author":"Lukas C","year":"2007","journal-title":"J Rheumatol"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10883"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21337"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22627"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.022582"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2009.08.009"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2010.06.001"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-006-0372-5"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.090352"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270401"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken207"},{"key":"e_1_2_6_20_1","first-page":"2286","article-title":"A new approach to defining disease status in ankylosing spondylitis: the Bath Ankylosing Spondylitis Disease Activity Index","volume":"21","author":"Garrett S","year":"1994","journal-title":"J Rheumatol"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200108)44:8<1876::AID-ART326>3.0.CO;2-F"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1109\/83.661186"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1109\/42.668698"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-199907000-00004"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-0298-6_4"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2010.161"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27571"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.111435"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2496"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24132"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.108233"}],"container-title":["Arthritis &amp; Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.39126","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.39126","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.39126","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T11:29:18Z","timestamp":1759922958000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/art.39126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,26]]},"references-count":30,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1002\/art.39126"],"URL":"https:\/\/doi.org\/10.1002\/art.39126","archive":["Portico"],"relation":{},"ISSN":["2326-5191","2326-5205"],"issn-type":[{"type":"print","value":"2326-5191"},{"type":"electronic","value":"2326-5205"}],"subject":[],"published":{"date-parts":[[2015,6,26]]}}}