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This study was undertaken to examine the effects of repeated exposure to WBV on bone and joint tissues in an in vivo mouse model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ten\u2010week\u2010old male mice were exposed to vertical sinusoidal vibration under conditions that mimic those used clinically in humans (30 minutes per day, 5 days per week, at 45 Hz with peak acceleration at 0.3<jats:italic>g<\/jats:italic>). Following WBV, skeletal tissues were examined by micro\u2013computed tomography, histologic analysis, and immunohistochemistry, and gene expression was quantified using real\u2010time polymerase chain reaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Following 4 weeks of WBV, intervertebral discs showed histologic hallmarks of degeneration in the annulus fibrosus, disruption of collagen organization, and increased cell death. Greater <jats:italic>Mmp3<\/jats:italic> expression in the intervertebral disc, accompanied by enhanced collagen and aggrecan degradation, was found in mice exposed to WBV as compared to controls. Examination of the knee joints after 4 weeks of WBV revealed meniscal tears and focal damage to the articular cartilage, changes resembling osteoarthritis. Moreover, mice exposed to WBV also demonstrated greater <jats:italic>Mmp13<\/jats:italic> gene expression and enhanced matrix metalloproteinase\u2013mediated collagen and aggrecan degradation in articular cartilage as compared to controls. No changes in trabecular bone microarchitecture or density were detected in the proximal tibia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our experiments reveal significant negative effects of WBV on joint tissues in a mouse model. These findings suggest the need for future studies of the effects of WBV on joint health in humans.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.39154","type":"journal-article","created":{"date-parts":[[2015,4,17]],"date-time":"2015-04-17T11:02:35Z","timestamp":1429268555000},"page":"2164-2175","source":"Crossref","is-referenced-by-count":62,"title":["Repeated Exposure to High\u2010Frequency Low\u2010Amplitude Vibration Induces Degeneration of Murine Intervertebral Discs and Knee Joints"],"prefix":"10.1002","volume":"67","author":[{"given":"Matthew R.","family":"McCann","sequence":"first","affiliation":[{"name":"University of Western Ontario Schulich School of Medicine and Dentistry London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priya","family":"Patel","sequence":"additional","affiliation":[{"name":"University of Western Ontario Schulich School of Medicine and Dentistry London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Pest","sequence":"additional","affiliation":[{"name":"University of Western Ontario Schulich School of Medicine and Dentistry London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anusha","family":"Ratneswaran","sequence":"additional","affiliation":[{"name":"University of Western Ontario Schulich School of Medicine and Dentistry London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurkeet","family":"Lalli","sequence":"additional","affiliation":[{"name":"University of Western Ontario Schulich School of Medicine and Dentistry London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim L.","family":"Beaucage","sequence":"additional","affiliation":[{"name":"University of Western Ontario Schulich School of Medicine and Dentistry London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garth B.","family":"Backler","sequence":"additional","affiliation":[{"name":"University of Western Ontario Schulich School of Medicine and Dentistry London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meg P.","family":"Kamphuis","sequence":"additional","affiliation":[{"name":"University of Western Ontario Schulich School of Medicine and Dentistry London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziana","family":"Esmail","sequence":"additional","affiliation":[{"name":"University of Western Ontario Schulich School of Medicine and Dentistry London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimin","family":"Lee","sequence":"additional","affiliation":[{"name":"University of Western Ontario Schulich School of Medicine and Dentistry London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Barbalinardo","sequence":"additional","affiliation":[{"name":"University of Western Ontario Schulich School of Medicine and Dentistry London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John S.","family":"Mort","sequence":"additional","affiliation":[{"name":"Shriners Hospital for Children and McGill University Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Holdsworth","sequence":"additional","affiliation":[{"name":"Robarts Research Institute and University of Western Ontario, Schulich School of Medicine and Dentistry London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Beier","sequence":"additional","affiliation":[{"name":"University of Western Ontario Schulich School of Medicine and Dentistry London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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