{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T05:50:25Z","timestamp":1793512225096,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,7,28]],"date-time":"2015-07-28T00:00:00Z","timestamp":1438041600000},"content-version":"vor","delay-in-days":88,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"OAI"},{"name":"University of Pittsburgh (Pivotal OAI MRI Analyses [POMA]: NIH\/National Heart, Lung, and Blood Institute)","award":["HHSN2682010000 21C"],"award-info":[{"award-number":["HHSN2682010000 21C"]}]},{"name":"OAI coordinating center at the University of California, San Francisco","award":["N01-AR-2-2258"],"award-info":[{"award-number":["N01-AR-2-2258"]}]},{"name":"NIH","award":["N01-AR-2-2258"],"award-info":[{"award-number":["N01-AR-2-2258"]}]},{"name":"NIH","award":["N01-AR-2-2259"],"award-info":[{"award-number":["N01-AR-2-2259"]}]},{"name":"NIH","award":["N01-AR-2-2260"],"award-info":[{"award-number":["N01-AR-2-2260"]}]},{"name":"NIH","award":["N01-AR-2-2261"],"award-info":[{"award-number":["N01-AR-2-2261"]}]},{"name":"NIH","award":["N01-AR-2-2262"],"award-info":[{"award-number":["N01-AR-2-2262"]}]},{"name":"Merck Research Laboratories"},{"name":"Novartis Pharmaceuticals"},{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Pfizer, Inc."},{"name":"OAI Study Investigators"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess whether the presence of structural osteoarthritis (OA) features over as many as 4 years prior to incident radiographic OA increases the risk of radiographic OA in a nested, case\u2013control design.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We studied 355 knees from the Osteoarthritis Initiative cohort that developed radiographic OA before the 48\u2010month visit. They were matched one\u2010to\u2010one by sex, age, and contralateral knee radiographic status with a control knee. Magnetic resonance images (MRIs) were read for bone marrow lesions (BMLs), cartilage damage, meniscal damage (including tears and extrusion), Hoffa synovitis, and effusion synovitis. Conditional logistic regression was applied to assess the risk of radiographic OA with regard to the presence of BMLs (score \u22652), cartilage lesions (score \u22651.1), meniscal damage (any) and extrusion of \u22653 mm \u00b1 (score \u22652), and Hoffa and effusion synovitis (any). Time points were defined as incident radiographic OA visit (P0), 1 year prior to the detection of radiographic OA (P \u22121), 2 years prior to the detection of radiographic OA (P \u22122), etc.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The presence of Hoffa synovitis (hazard ratio [HR] 1.76 [95% confidence interval (95% CI) 1.18\u20132.64]), effusion synovitis (HR 1.81 [95% CI 1.18\u20132.78]), and medial meniscal damage (HR 1.83 [95% CI 1.17\u20132.89]) at P \u22122 predicted radiographic OA incidence. At P \u22121, all features but meniscal extrusion predicted radiographic OA, with highest odds for medial BMLs (HR 6.50 [95% CI 2.27\u201318.62]) and effusion synovitis (HR 2.50 [95% CI 1.76\u20133.54]). The findings at P \u22123 and P \u22124 did not reach statistical significance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings indicate that the presence of specific structural features of MRI\u2010detected joint damage 2 years prior to incident radiographic OA increases the risk of incident radiographic OA. However, 1 year prior to radiographic OA, the presence of almost any abnormal morphologic feature increases the risk of radiographic OA in the subsequent year.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.39176","type":"journal-article","created":{"date-parts":[[2015,5,4]],"date-time":"2015-05-04T13:46:00Z","timestamp":1430747160000},"page":"2085-2096","source":"Crossref","is-referenced-by-count":177,"title":["What Comes First? Multitissue Involvement Leading to Radiographic Osteoarthritis: Magnetic Resonance Imaging\u2013Based Trajectory Analysis Over Four Years in the Osteoarthritis Initiative"],"prefix":"10.1002","volume":"67","author":[{"given":"Frank W.","family":"Roemer","sequence":"first","affiliation":[{"name":"Boston University School of Medicine, Boston, Massachusetts, and University of Erlangen\u2013Nuremberg Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Kent","family":"Kwoh","sequence":"additional","affiliation":[{"name":"University of Arizona College of Medicine, Tucson, and University of Pittsburgh Graduate School of Public Health Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Hannon","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Graduate School of Public Health Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Hunter","sequence":"additional","affiliation":[{"name":"Royal North Shore Hospital, Institute of Bone and Joint Research, Kolling Institute of Medical Research, and University of Sydney St. Leonards New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Eckstein","sequence":"additional","affiliation":[{"name":"Paracelsus Medical University, Salzburg, Austria, and Chondrometrics GmbH Ainring Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Fujii","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Graduate School of Public Health Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Boudreau","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Graduate School of Public Health Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Guermazi","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60243-2"},{"key":"e_1_2_7_3_1","unstructured":"Agency for Healthcare Research and Quality. Healthcare Cost and Utilization Project (HCUP): overview of the National (Nationwide) Inpatient Sample (NIS). 1999\u20102008. 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URL:http:\/\/www.oai.ucsf.edu\/datarelease\/docs\/StudyDesignProtocol.pdf."},{"key":"e_1_2_7_21_1","unstructured":"MRI procedure manual for examinations of the knee and thigh. Osteoarthritis Initiative: a knee health study. Version 1.0j. 2006. URL:http:\/\/oai.epi\u2010ucsf.org\/datarelease\/operationsManuals\/MRI_ManualRev.pdf."},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-002-0603-z"},{"key":"e_1_2_7_23_1","unstructured":"Osteoarthritis Initiative. Central reading of knee X\u2010rays for K\u2010L grade and individual radiographic features of knee OA. Appendix A. Project 15: reader discrepancies and adjudication procedures; p. 8. URL:http:\/\/oai.epi\u2010ucsf.org\/datarelease\/forms\/kXR_SQ_BU_Descrip.pdf?V01XRKL."},{"key":"e_1_2_7_24_1","doi-asserted-by":"crossref","unstructured":"HunterDJ GuermaziA LoGH GraingerAJ ConaghanPG BoudreauRM et al. 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