{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T23:16:16Z","timestamp":1782774976677,"version":"3.54.5"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,8,26]],"date-time":"2015-08-26T00:00:00Z","timestamp":1440547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Rose Hellaby Medical Trust Scholarship of New Zealand"},{"name":"Asia Pacific League of Associations for Rheumatology Fellowship"},{"name":"British Maternal and Fetal Medicine Society Bursary"},{"DOI":"10.13039\/501100000272","name":"National Institute of Health Research, UK","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Tommy's Charity, UK"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine if maternal placental syndromes (MPS) are associated with an increased risk of death from cardiovascular causes in women with systemic lupus erythematosus (SLE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between 1973 and 2011, women with SLE and a history of pregnancy were identified using linked Swedish population registries. The outcome was death from primarily cardiovascular causes, defined as death from acute coronary syndrome or coronary artery disease, stroke, or peripheral vascular disease. The exposure was MPS, defined as any hypertensive disorders in pregnancy, stillbirth, placental abruption, or delivery of a small\u2010for\u2010gestational\u2010age infant. The association of preterm delivery (delivery at &lt;34 weeks of gestation) with death from cardiovascular causes was also explored. Risk of death from cardiovascular causes was determined using logistic regression, adjusting for the year of first delivery, duration of SLE, number of inpatient admissions, and cardiovascular risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 3,977 women with SLE had 7,410 pregnancies during the study interval. Death from primarily cardiovascular causes occurred in 44 of the 325 women who died (13.5%). The median age at death from cardiovascular causes was 54 years (interquartile range 48\u201358 years), and these women were more likely to have had hypertension and renal disease. MPS was associated with an increased risk of death from primarily cardiovascular causes (adjusted odds ratio [OR] 2.19 [95% confidence interval (95% CI) 1.14\u20134.22]), specifically, a history of placental abruption (adjusted OR 5.78 [95% CI 1.61\u201320.72]). Delivery at &lt;34 weeks of gestation, particularly when combined with MPS, was also associated with an increased risk of death from primarily cardiovascular causes (adjusted OR 2.49 [95% CI 1.06\u20135.85]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MPS in pregnancy is associated with a higher risk of death from primarily cardiovascular causes in women with SLE.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.39218","type":"journal-article","created":{"date-parts":[[2015,5,27]],"date-time":"2015-05-27T13:59:22Z","timestamp":1432735162000},"page":"2376-2382","source":"Crossref","is-referenced-by-count":23,"title":["Brief Report: Association Between Pregnancy Outcomes and Death From Cardiovascular Causes in Parous Women With Systemic Lupus Erythematosus: A Study Using Swedish Population Registries"],"prefix":"10.1002","volume":"67","author":[{"given":"May Ching","family":"Soh","sequence":"first","affiliation":[{"name":"Women's Health Academic Centre, King's College London, and King's Health Partners, London, UK, and University of Auckland and National Women's Health Auckland New Zealand (current address: John Radcliffe Hospital, Oxford University Hospitals NHS Trust, Oxford, UK, and Queen Charlotte's and Chelsea Hospital, Imperial College Healthcare NHS Trust, London, UK)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Nelson\u2010Piercy","sequence":"additional","affiliation":[{"name":"Women's Health Academic Centre, King's College London, and King's Health Partners London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadia","family":"Dib","sequence":"additional","affiliation":[{"name":"Women's Health Academic Centre, King's College London, and King's Health Partners London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Westgren","sequence":"additional","affiliation":[{"name":"Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesley","family":"McCowan","sequence":"additional","affiliation":[{"name":"University of Auckland and National Women's Health Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dharmintra","family":"Pasupathy","sequence":"additional","affiliation":[{"name":"Women's Health Academic Centre, King's College London, and King's Health Partners London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,8,26]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"713","article-title":"Cardiovascular disease a hazard despite improved prognosis in patients with systemic lupus erythematosus: results from a Swedish population based study 1964\u201095","volume":"31","author":"Bjornadal L","year":"2004","journal-title":"J Rheumatol"},{"key":"e_1_2_6_3_1","first-page":"S72","article-title":"An update on mortality in systemic lupus erythematosus","volume":"26","author":"Ippolito A","year":"2008","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22173"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21663"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.03.012"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67726-4"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39335.385301.BE"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2008.06.042"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-11-450"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1996.tb14164.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035471"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker285"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24469"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.080214"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39366.416817.BE"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.02.104"},{"key":"e_1_2_6_18_1","first-page":"631","article-title":"Soluble Fms\u2010like tyrosine kinase associated with preeclampsia in pregnancy in systemic lupus erythematosus [published erratum appears in J Rheumatol 2008;35:729]","volume":"35","author":"Qazi U","year":"2008","journal-title":"J Rheumatol"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2011.11.005"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.puhe.2008.07.010"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.02.005"}],"container-title":["Arthritis &amp; 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