{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T23:59:26Z","timestamp":1789430366054,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,9,23]],"date-time":"2015-09-23T00:00:00Z","timestamp":1442966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100002429","name":"Amgen, Inc.","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100002429","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Systemic lupus erythematosus (SLE) is a complex autoimmune disease that is driven in part by chronic B and T lymphocyte hyperresponsiveness to self antigens. A deficiency of interleukin\u201021 (IL\u201021) or IL\u201021 receptor (IL\u201021R) in mice dramatically reduces inflammation and B and T cell activation in models of autoimmunity, including SLE. However, whether IL\u201021 is essential for the maintenance and amplification of preestablished inflammation has not been widely examined in various animal models. The purpose of this study was to examine the impact of novel mouse IL\u201021R neutralizing antibodies on recall responses to antigen challenge and on disease progression in the (NZB \u00d7 NZW)F1 (NZB\/NZW) mouse model of SLE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Humoral and cellular immune responses to immunization with sheep red blood cells (SRBCs) were measured in mice dosed with IL\u201021R blocking antibodies. Progression of nephritis and markers of immune activation was monitored in NZB\/NZW mice following different anti\u2013IL\u201021R treatment regimens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>IL\u201021R blockade specifically inhibited secondary IgG responses to SRBC immunization. In NZB\/NZW mice, IL\u201021R blockade completely inhibited the onset of nephritis, which was associated with dramatic reductions in splenomegaly and in B cell and T cell activation. When administered to mice with preexisting disease, anti\u2013IL\u201021R antibody halted the disease progression and mortality and reversed the nephritis in a subset of mice. Furthermore, treatment cessation was not followed by rapid reemergence of disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results highlight the importance of IL\u201021 in promoting humoral recall responses and in sustaining autoimmune inflammation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.39233","type":"journal-article","created":{"date-parts":[[2015,6,20]],"date-time":"2015-06-20T04:08:10Z","timestamp":1434773290000},"page":"2723-2731","source":"Crossref","is-referenced-by-count":26,"title":["Interleukin\u201021 Receptor Blockade Inhibits Secondary Humoral Responses and Halts the Progression of Preestablished Disease in the (NZB \u00d7 NZW)F1 Systemic Lupus Erythematosus Model"],"prefix":"10.1002","volume":"67","author":[{"given":"Ming","family":"Zhang","sequence":"first","affiliation":[{"name":"Amgen, Inc. Thousand Oaks  California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Yu","sequence":"additional","affiliation":[{"name":"Amgen, Inc. Thousand Oaks  California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Chan","sequence":"additional","affiliation":[{"name":"Amgen, Inc. Burnaby  British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua T.","family":"Pearson","sequence":"additional","affiliation":[{"name":"Amgen, Inc. Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Palaniswami","family":"Rathanaswami","sequence":"additional","affiliation":[{"name":"Amgen, Inc. Burnaby  British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Delaney","sequence":"additional","affiliation":[{"name":"Amgen, Inc. 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