{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T20:41:27Z","timestamp":1789072887695,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,9,23]],"date-time":"2015-09-23T00:00:00Z","timestamp":1442966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"name":"Bristol-Myers Squibb"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The efficacy and safety of abatacept in patients with juvenile idiopathic arthritis (JIA) who experienced an inadequate response to disease\u2010modifying antirheumatic drugs were previously established in a phase III study that included a 4\u2010month open\u2010label lead\u2010in period, a 6\u2010month double\u2010blind withdrawal period, and a long\u2010term extension (LTE) phase. The aim of this study was to present the safety, efficacy, and patient\u2010reported outcomes of abatacept treatment (10 mg\/kg every 4 weeks) during the LTE phase, for up to 7 years of followup.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients enrolled in the phase III trial could enter the open\u2010label LTE phase if they had not achieved a response to treatment at month 4 or if they had received abatacept or placebo during the double\u2010blind period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>One hundred fifty\u2010three (80.5%) of 190 patients entered the LTE phase, and 69 patients (36.3%) completed it. The overall incidence rate (events per 100 patient\u2010years) of adverse events decreased during the LTE phase (433.61 events during the short\u2010term phase [combined lead\u2010in and double\u2010blind periods] versus 132.39 events during the LTE phase). Similar results were observed for serious adverse events (6.82 versus 5.60), serious infections (1.13 versus 1.72), malignancies (1.12 versus 0), and autoimmune events (2.26 versus 1.18). American College of Rheumatology (ACR) Pediatric 30 (Pedi 30) responses, Pedi 70 responses, and clinically inactive disease status were maintained throughout the LTE phase in patients who continued to receive therapy. Improvements in the Child Health Questionnaire physical and psychosocial summary scores were maintained over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Long\u2010term abatacept treatment for up to 7 years was associated with consistent safety, sustained efficacy, and quality\u2010of\u2010life benefits in patients with JIA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.39234","type":"journal-article","created":{"date-parts":[[2015,6,20]],"date-time":"2015-06-20T04:08:27Z","timestamp":1434773307000},"page":"2759-2770","source":"Crossref","is-referenced-by-count":82,"title":["Long\u2010Term Safety, Efficacy, and Quality of Life in Patients With Juvenile Idiopathic Arthritis Treated With Intravenous Abatacept for Up to Seven Years"],"prefix":"10.1002","volume":"67","author":[{"given":"Daniel J.","family":"Lovell","sequence":"first","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolino","family":"Ruperto","sequence":"additional","affiliation":[{"name":"IRCCS G. 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