{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:47:35Z","timestamp":1787064455890,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,9,23]],"date-time":"2015-09-23T00:00:00Z","timestamp":1442966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Portuguese Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["PTDC\/SAU-GMG\/098937\/2008"],"award-info":[{"award-number":["PTDC\/SAU-GMG\/098937\/2008"]}]},{"name":"Portuguese Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["PTDC\/IIM-GES\/5015\/2012"],"award-info":[{"award-number":["PTDC\/IIM-GES\/5015\/2012"]}]},{"name":"Portuguese Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["CMUP-ERI\/TPE\/0028\/2013"],"award-info":[{"award-number":["CMUP-ERI\/TPE\/0028\/2013"]}]},{"name":"Portuguese Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["SFRH\/BPD\/70008\/2010"],"award-info":[{"award-number":["SFRH\/BPD\/70008\/2010"]}]},{"name":"Portuguese Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["SFRH\/BD\/43895\/2008"],"award-info":[{"award-number":["SFRH\/BD\/43895\/2008"]}]},{"name":"Research Committee of the Tehran University of Medical Sciences","award":["132\/714"],"award-info":[{"award-number":["132\/714"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis & Rheumatology"],"published-print":{"date-parts":[[2015,10]]},"abstract":"\n Objective<\/jats:title>\n To independently replicate the top findings from 4 published genome\u2010wide association studies (GWAS) of susceptibility genes in Beh\u00e7et's disease (BD).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We tested 14 single\u2010nucleotide polymorphisms (SNPs) in 13 genomic loci (excluding the major histocompatibility complex [MHC],\n IL10<\/jats:italic>\n , and\n IL23R\u2013IL12RB2<\/jats:italic>\n , which have already been associated with BD in Iranians) for allelic and genotypic associations with BD in 973 patients and 828 controls from Iran and performed meta\u2010analyses of the significantly associated markers.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Six SNPs (in decreasing order of significance, rs7616215 located 38 kb downstream of\n CCR1<\/jats:italic>\n , rs2617170 [p.Asn104Ser] in\n KLRC4<\/jats:italic>\n , rs17810546 in\n IL12A\u2013AS1<\/jats:italic>\n , rs7574070 in\n STAT4<\/jats:italic>\n , and rs10050860 [p.Asp575Asn] and rs13154629 in\n ERAP1<\/jats:italic>\n ) were nominally associated with BD in both allelic association tests (5.05 \u00d7 10\n \u22129<\/jats:sup>\n \u2264\n P<\/jats:italic>\n allele<\/jats:sub>\n \u2264 7.55 \u00d7 10\n \u22123<\/jats:sup>\n ) and sex\u2010adjusted genotypic association tests (6.01 \u00d7 10\n \u22129<\/jats:sup>\n \u2264 adjusted\n P<\/jats:italic>\n value \u2264 1.30 \u00d7 10\n \u22122<\/jats:sup>\n ). For all 6 SNPs tested by meta\u2010analysis (\n P<\/jats:italic>\n meta<\/jats:sub>\n ), the association with BD was strengthened, because the direction and magnitude of association were similar across populations (e.g., for rs7574070, odds ratio [OR] for A allele 1.29 [95% confidence interval (95% CI) 1.21\u20131.37],\n P<\/jats:italic>\n meta<\/jats:sub>\n \u2009=\u20092.34 \u00d7 10\n \u221216<\/jats:sup>\n ; for rs7616215, OR for C allele 0.70 [95% CI 0.65\u20130.76],\n P<\/jats:italic>\n meta<\/jats:sub>\n \u2009=\u20091.54 \u00d7 10\n \u221219<\/jats:sup>\n ; for rs17810546, OR for A allele 0.60 [95% CI 0.52\u20130.70],\n P<\/jats:italic>\n meta<\/jats:sub>\n \u2009=\u20096.34 \u00d7 10\n \u221211<\/jats:sup>\n ; for rs2617170, OR for T allele 0.76 [95% CI 0.70\u20130.81],\n P<\/jats:italic>\n meta<\/jats:sub>\n \u2009=\u20092.75 \u00d7 10\n \u221214<\/jats:sup>\n ; for rs13154629, OR for TT genotype 2.76 [95% CI 2.01\u20133.80],\n P<\/jats:italic>\n meta<\/jats:sub>\n \u2009=\u20093.57 \u00d7 10\n \u221210<\/jats:sup>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n This study reinforces the notion that\n CCR1<\/jats:italic>\n ,\n KLRC4<\/jats:italic>\n ,\n IL12A\u2013AS1<\/jats:italic>\n ,\n STAT4<\/jats:italic>\n , and\n ERAP1<\/jats:italic>\n are bona fide susceptibility genes for BD, in addition to the MHC,\n IL10,<\/jats:italic>\n and\n IL23R\u2013IL12RB2<\/jats:italic>\n loci. Future genetic and functional studies are now warranted to uncover the roles of these genes in the pathogenesis of BD.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/art.39240","type":"journal-article","created":{"date-parts":[[2015,6,20]],"date-time":"2015-06-20T04:09:16Z","timestamp":1434773356000},"page":"2742-2748","source":"Crossref","is-referenced-by-count":41,"title":["Brief Report: Association of\n CCR1<\/i>\n ,\n KLRC4<\/i>\n ,\n IL12A\u2013AS1<\/i>\n ,\n STAT4<\/i>\n , and\n ERAP1<\/i>\n With Beh\u00e7et's Disease in Iranians"],"prefix":"10.1002","volume":"67","author":[{"given":"In\u00eas","family":"Sousa","sequence":"first","affiliation":[{"name":"Instituto de Medicina Molecular and Universidade de Lisboa, Lisbon, Portugal, and Instituto Gulbenkian de Ci\u00eancia Oeiras Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhad","family":"Shahram","sequence":"additional","affiliation":[{"name":"Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Francisco","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular and Universidade de Lisboa, Lisbon, Portugal, and Instituto Gulbenkian de Ci\u00eancia Oeiras Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fereydoun","family":"Davatchi","sequence":"additional","affiliation":[{"name":"Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahar Sadeghi","family":"Abdollahi","sequence":"additional","affiliation":[{"name":"Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahmida","family":"Ghaderibarmi","sequence":"additional","affiliation":[{"name":"Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdolhadi","family":"Nadji","sequence":"additional","affiliation":[{"name":"Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niloofar","family":"Mojarad Shafiee","sequence":"additional","affiliation":[{"name":"Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joana M.","family":"Xavier","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular and Universidade de Lisboa, Lisbon, Portugal, and Instituto Gulbenkian de Ci\u00eancia Oeiras Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia A.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular and Universidade de Lisboa, Lisbon, Portugal, and Instituto Gulbenkian de Ci\u00eancia Oeiras 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