{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:04:46Z","timestamp":1792782286190,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,9,9]],"date-time":"2015-09-09T00:00:00Z","timestamp":1441756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"name":"American College of Rheumatology and the European League Against Rheumatism","id":[{"id":"https:\/\/ror.org\/03f7j3221","id-type":"ROR","asserted-by":"crossref"}]},{"name":"NIH","award":["P60-AR-47785"],"award-info":[{"award-number":["P60-AR-47785"]}]},{"name":"NIH","award":["K23-AR-055127"],"award-info":[{"award-number":["K23-AR-055127"]}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Agency for Healthcare Research and Quality (Center for Education and Research on Therapeutics program","id":[{"id":"https:\/\/ror.org\/03jmfdf59","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/100013459","name":"Arthritis New Zealand","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100013459","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Existing criteria for the classification of gout have suboptimal sensitivity and\/or specificity, and were developed at a time when advanced imaging was not available. The current effort was undertaken to develop new classification criteria for gout.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An international group of investigators, supported by the American College of Rheumatology and the European League Against Rheumatism, conducted a systematic review of the literature on advanced imaging of gout, a diagnostic study in which the presence of monosodium urate monohydrate (MSU) crystals in synovial fluid or tophus was the gold standard, a ranking exercise of paper patient cases, and a multicriterion decision analysis exercise. These data formed the basis for developing the classification criteria, which were tested in an independent data set.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The entry criterion for the new classification criteria requires the occurrence of at least 1 episode of peripheral joint or bursal swelling, pain, or tenderness. The presence of MSU crystals in a symptomatic joint\/bursa (i.e., synovial fluid) or in a tophus is a sufficient criterion for classification of the subject as having gout, and does not require further scoring. The domains of the new classification criteria include clinical (pattern of joint\/bursa involvement, characteristics and time course of symptomatic episodes), laboratory (serum urate, MSU\u2010negative synovial fluid aspirate), and imaging (double\u2010contour sign on ultrasound or urate on dual\u2010energy computed tomography, radiographic gout\u2010related erosion). The sensitivity and specificity of the criteria are high (92% and 89%, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The new classification criteria, developed using a data\u2010driven and decision analytic approach, have excellent performance characteristics and incorporate current state\u2010of\u2010the\u2010art evidence regarding gout.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.39254","type":"journal-article","created":{"date-parts":[[2015,9,10]],"date-time":"2015-09-10T09:03:46Z","timestamp":1441875826000},"page":"2557-2568","source":"Crossref","is-referenced-by-count":547,"title":["2015 Gout Classification Criteria: An American College of Rheumatology\/European League Against Rheumatism Collaborative Initiative"],"prefix":"10.1002","volume":"67","author":[{"given":"Tuhina","family":"Neogi","sequence":"first","affiliation":[{"name":"Boston University School of Medicine Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim L. Th. A.","family":"Jansen","sequence":"additional","affiliation":[{"name":"Viecuri Medical Center, Venlo, The Netherlands, and Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Dalbeth","sequence":"additional","affiliation":[{"name":"University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaap","family":"Fransen","sequence":"additional","affiliation":[{"name":"Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Ralph","family":"Schumacher","sequence":"additional","affiliation":[{"name":"University of Pennsylvania Philadelphia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianne","family":"Berendsen","sequence":"additional","affiliation":[{"name":"Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Brown","sequence":"additional","affiliation":[{"name":"University of Otago Wellington New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyon","family":"Choi","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. Lawrence","family":"Edwards","sequence":"additional","affiliation":[{"name":"University of Florida Gainesville"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hein J. E. M.","family":"Janssens","sequence":"additional","affiliation":[{"name":"Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Liot\u00e9","sequence":"additional","affiliation":[{"name":"Fr\u00e9d\u00e9ric Liot\u00e9, MD, PhD: INSERM UMR 1132 H\u00f4pital Lariboisi\u00e8re, AP\u2010HP, and Universit\u00e9 Paris Diderot Sorbonne Paris Cit\u00e9, Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond P.","family":"Naden","sequence":"additional","affiliation":[{"name":"McMaster University Medical Centre Hamilton, Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Nuki","sequence":"additional","affiliation":[{"name":"University of Edinburgh Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Ogdie","sequence":"additional","affiliation":[{"name":"University of Pennsylvania Philadelphia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Perez\u2010Ruiz","sequence":"additional","affiliation":[{"name":"Hospital Universitario Cruces and BioCruces Health Research Institute Vizcaya Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Saag","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasvinder A.","family":"Singh","sequence":"additional","affiliation":[{"name":"Birmingham VA Medical Center and University of Alabama at Birmingham, and Mayo Clinic College of Medicine Rochester  Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John S.","family":"Sundy","sequence":"additional","affiliation":[{"name":"Gilead Sciences, Foster City, California)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Kathrin","family":"Tausche","sequence":"additional","affiliation":[{"name":"University Hospital Carl Gustav Carus Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janitzia","family":"Vaquez\u2010Mellado","sequence":"additional","affiliation":[{"name":"Hospital General de Mexico Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven A.","family":"Yarows","sequence":"additional","affiliation":[{"name":"University of Michigan Health System Chelsea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Taylor","sequence":"additional","affiliation":[{"name":"University of Otago Wellington New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30520"},{"key":"e_1_2_8_3_1","article-title":"Identification of patients with gout: elaboration of a questionnaire for epidemiological studies","author":"Richette P","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-eular.5164"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.076232"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204463"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.024091"},{"key":"e_1_2_8_8_1","first-page":"53","article-title":"Gout, diabetes and cardiovascular disease in the Aotearoa New Zealand adult population: co\u2010prevalence and implications for clinical practice","volume":"126","author":"Winnard D","year":"2013","journal-title":"N Z Med J"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1001124"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23018"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780200320"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2010.196"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.091385"},{"key":"e_1_2_8_14_1","first-page":"326","volume-title":"The epidemiology of chronic rheumatism","author":"Kellgren JH","year":"1963"},{"key":"e_1_2_8_15_1","unstructured":"DeckerJL.Report from the subcommittee on diagnostic criteria for gout. 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