{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:35:26Z","timestamp":1760985326696,"version":"build-2065373602"},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,11,25]],"date-time":"2015-11-25T00:00:00Z","timestamp":1448409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science, and Technology of Japan","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Rheumatoid arthritis (RA) is a chronic disease leading to joint destruction. Although many studies have addressed factors potentially correlated with the speed of joint destruction, less attention has been paid to the distribution of joint destruction in patients with RA. In this study, destruction of the hand bones in patients with RA was classified into 2 anatomic subgroups, the fingers and the non\u2010fingers, with the aim of analyzing which factors are associated with destruction of the finger joints.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 1,215 Japanese patients with RA were recruited from 2 different populations. The degree of joint destruction was assessed using the total modified Sharp\/van der Heijde score (SHS) of radiographic joint damage. The SHS score of joint damage in the finger joints was used as the dependent variable, and the SHS score in the non\u2010finger joints was used as a covariate. Age, sex, disease duration, smoking, C\u2010reactive protein level, treatment for RA, and positivity for and levels of anti\u2013citrullinated protein antibodies and rheumatoid factor (RF) were evaluated as candidate correlates. Overall effect sizes were assessed in a meta\u2010analysis. In addition, associations observed in the Japanese patients were compared to those in a cohort of 157 Dutch RA patients in the BeSt study (a randomized, controlled trial involving 4 different strictly specified treatment strategies for early RA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Not surprisingly, disease duration in Japanese patients with RA was associated with the finger SHS score (<jats:italic>P<\/jats:italic> \u2264 0.00037). Both positivity for and levels of RF showed significant associations with the finger SHS score after adjustment for covariates (<jats:italic>P<\/jats:italic>\u2009=\u20090.0022 and <jats:italic>P<\/jats:italic>\u2009=\u20098.1 \u00d7 10<jats:sup>\u22127<\/jats:sup>, respectively). These associations were also true in relation to the time\u2010averaged finger SHS score. An association between RF positivity and the finger SHS score was also observed in Dutch patients with RA in the BeSt study (<jats:italic>P<\/jats:italic>\u2009=\u20090.049).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Positivity for and levels of RF are associated with finger joint destruction independent of non\u2010finger joint destruction and other covariates. Our findings suggest that there are different mechanisms of joint destruction operating in the finger joints of patients with RA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.39306","type":"journal-article","created":{"date-parts":[[2015,8,5]],"date-time":"2015-08-05T20:36:45Z","timestamp":1438807005000},"page":"3113-3123","source":"Crossref","is-referenced-by-count":27,"title":["Rheumatoid Factor Is Associated With the Distribution of Hand Joint Destruction in Rheumatoid Arthritis"],"prefix":"10.1002","volume":"67","author":[{"given":"Chikashi","family":"Terao","sequence":"first","affiliation":[{"name":"Kyoto University Graduate School of Medicine, Kyoto, Japan, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, and Broad Institute Cambridge  Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriyuki","family":"Yamakawa","sequence":"additional","affiliation":[{"name":"Kyoto University Graduate School of Medicine Kyoto 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