{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:35:46Z","timestamp":1780472146572,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,12,23]],"date-time":"2015-12-23T00:00:00Z","timestamp":1450828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Institute on Aging of the National Institutes of Health","award":["R01AG034676"],"award-info":[{"award-number":["R01AG034676"]}]},{"name":"CTSA","award":["UL1 TR000135"],"award-info":[{"award-number":["UL1 TR000135"]}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences (NCATS)","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health (NIH)","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Mayo Clinic Career Development Award"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the incidence and prevalence of juvenile idiopathic arthritis (JIA) in Olmsted County, Minnesota in 1994\u20132013 and trends in juvenile rheumatoid arthritis (JRA) in 1960\u20132013.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cases of arthritis in 1994\u20132013 were identified by diagnosis code with medical chart review to confirm diagnosis separately for JIA and JRA. Overall incidence rates with 95% confidence intervals (95% CIs) were age and sex adjusted to the 2010 US white population. Comparisons were made with an earlier (1960\u20131993) cohort from this same population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010one incident cases of JIA in 1994\u20132013 were identified, with an overall age\u2010 and sex\u2010adjusted incidence rate of 10.3 per 100,000 (95% CI 7.9\u201312.7). Forty\u2010two (59%) were female, with an incidence of 12.4 per 100,000 (95% CI 8.6\u201316.2), as compared to 8.3 per 100,000 (95% CI 5.2\u201311.3) in males. The most common subtype was oligoarthritis (63%). The mean\u2009\u00b1\u2009SD age at diagnosis was 8.2\u2009\u00b1\u20095.3 years. The prevalence of JIA on January 1, 2000 and January 1, 2010 was 51.0 per 100,000 (95% CI 25.2\u201376.8) and 57.6 per 100,000 (95% CI 31.0\u201394.5), respectively. When the annual incidence of JRA was compared over time from 1960 to 2013, there was no significant change in incidence overall; however, the incidence decreased among females (<jats:italic>P<\/jats:italic>\u2009=\u20090.003). A cyclic pattern of incidence was observed, with peaks approximately every 10 years. Similar to the findings with regard to incidence, prevalence did not change overall, but decreased among females (<jats:italic>P<\/jats:italic>\u2009=\u20090.048). There were 4 deaths in the cohort of JRA patients diagnosed in 1960\u20132013; the standardized mortality ratio was 1.50 (95% CI 0.41\u20133.83).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Incidence of juvenile arthritis overall in Olmsted County, Minnesota has not changed significantly in the past 53 years. A consistent cyclic pattern was noted.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.39323","type":"journal-article","created":{"date-parts":[[2015,8,28]],"date-time":"2015-08-28T10:44:01Z","timestamp":1440758641000},"page":"247-254","source":"Crossref","is-referenced-by-count":31,"title":["Juvenile Idiopathic Arthritis in Olmsted County, Minnesota, 1960\u20132013"],"prefix":"10.1002","volume":"68","author":[{"given":"Megan L.","family":"Krause","sequence":"first","affiliation":[{"name":"Mayo Clinic College of Medicine Rochester  Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia S.","family":"Crowson","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine Rochester  Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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