{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:39:42Z","timestamp":1790293182345,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,11,25]],"date-time":"2015-11-25T00:00:00Z","timestamp":1448409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"crossref","award":["FDM20140630463"],"award-info":[{"award-number":["FDM20140630463"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the relationship between Takayasu arteritis (TAK) and pregnancy outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included 240 pregnancies in 96 patients fulfilling the American College of Rheumatology 1990 criteria for the classification of TAK and\/or the 1994 Chapel Hill Consensus Conference nomenclature\/criteria for vasculitis. We analyzed obstetric and maternal outcomes in women who were pregnant before and\/or at the same time as or after TAK diagnosis. We assessed factors associated with complicated pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred forty\u2010two pregnancies occurred in 52 patients before TAK diagnosis (median age at pregnancy 26 years [interquartile range 23\u201330 years]), and 98 pregnancies occurred in 52 patients concomitant with or after TAK diagnosis (median age at pregnancy 28 years [interquartile range 26\u201331 years]). Pregnancies concomitant with or after TAK diagnosis had a 13\u2010fold higher rate of obstetric complications compared to pregnancies before TAK diagnosis (odds ratio 13 [95% confidence interval 5\u201333], <jats:italic>P<\/jats:italic> &lt; 0.0001). TAK was associated with a 40% frequency of obstetric complications, including preeclampsia\/eclampsia (24 pregnancies [24%]), premature delivery (8 pregnancies [8%]), and intrauterine fetal growth restriction or death (5 pregnancies [5%]). Maternal complications of TAK occurred during 39% of pregnancies and included mainly new\u2010onset or worsening hypertension (26 pregnancies [27%]). In multivariate analysis, smoking (odds ratio 6.15 [95% confidence interval 1.31\u201328.8]) and disease activity of TAK (a National Institutes of Health score of &gt;1) (odds ratio 28.7 [95% confidence interval 7.89\u2013104.7]) were independently associated with obstetric and maternal complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>TAK negatively affects pregnancy outcomes. Disease activity increases the risk of obstetric and maternal complications, mainly due to arterial hypertension.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.39335","type":"journal-article","created":{"date-parts":[[2015,8,28]],"date-time":"2015-08-28T11:49:48Z","timestamp":1440762588000},"page":"3262-3269","source":"Crossref","is-referenced-by-count":76,"title":["Takayasu Arteritis and Pregnancy"],"prefix":"10.1002","volume":"67","author":[{"given":"C.","family":"Comarmond","sequence":"first","affiliation":[{"name":"AP\u2010HP, Groupe Hospitalier Piti\u00e9\u2010Salp\u00eatri\u00e8re, Centre National de R\u00e9f\u00e9rence des Maladies Auto\u2010Immunes et Syst\u00e9miques Rares, and Universit\u00e9 Pierre et Marie Curie, Paris 6 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Mirault","sequence":"additional","affiliation":[{"name":"AP\u2010HP, H\u00f4pital Europ\u00e9en Georges\u2010Pompidou, INSERM UMR970, PARCC, Centre de R\u00e9f\u00e9rence des Maladies Vasculaires Rares, H\u00f4pitaux Universitaires Paris Ouest, and Universit\u00e9 Paris Descartes, Paris 5, Sorbonne Paris Cit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Biard","sequence":"additional","affiliation":[{"name":"AP\u2010HP, SBIM, H\u00f4pital Saint\u2010Louis and Universit\u00e9 Paris Diderot, Paris 7, INSERM, CRESS UMR\u2010S 1153 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Nizard","sequence":"additional","affiliation":[{"name":"AP\u2010HP, Groupe Hospitalier Piti\u00e9\u2010Salp\u00eatri\u00e8re and Sorbonne Universit\u00e9s, Universit\u00e9 Pierre et Marie Curie, Paris 6, CNRS UMR 7222, INSERM U1150 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Lambert","sequence":"additional","affiliation":[{"name":"H\u00f4pital Claude Huriez, Centre de R\u00e9f\u00e9rence des Maladies Auto\u2010Immunes et Syst\u00e9miques Rares, Centre Hospitalier R\u00e9gional Universitaire de Lille, and Universit\u00e9 de Lille 2 Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Wechsler","sequence":"additional","affiliation":[{"name":"AP\u2010HP, Groupe Hospitalier Piti\u00e9\u2010Salp\u00eatri\u00e8re, Centre National de R\u00e9f\u00e9rence des Maladies Auto\u2010Immunes et Syst\u00e9miques Rares, and Universit\u00e9 Pierre et Marie Curie, Paris 6 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Hachulla","sequence":"additional","affiliation":[{"name":"H\u00f4pital Claude Huriez, Centre de R\u00e9f\u00e9rence des Maladies Auto\u2010Immunes et Syst\u00e9miques Rares, Centre Hospitalier R\u00e9gional Universitaire de Lille, and Universit\u00e9 de Lille 2 Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Chiche","sequence":"additional","affiliation":[{"name":"AP\u2010HP, Groupe Hospitalier Piti\u00e9\u2010Salp\u00eatri\u00e8re and Universit\u00e9 Pierre et Marie Curie, Paris 6 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Koskas","sequence":"additional","affiliation":[{"name":"AP\u2010HP, Groupe Hospitalier Piti\u00e9\u2010Salp\u00eatri\u00e8re and Universit\u00e9 Pierre et Marie Curie, Paris 6 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Gaudric","sequence":"additional","affiliation":[{"name":"AP\u2010HP, Groupe Hospitalier Piti\u00e9\u2010Salp\u00eatri\u00e8re and Universit\u00e9 Pierre et Marie Curie, Paris 6 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Cluzel","sequence":"additional","affiliation":[{"name":"AP\u2010HP, Groupe Hospitalier Piti\u00e9\u2010Salp\u00eatri\u00e8re and Universit\u00e9 Pierre et Marie Curie, Paris 6, INSERM\u2010CNRS\u2010LIB Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Messas","sequence":"additional","affiliation":[{"name":"AP\u2010HP, H\u00f4pital Europ\u00e9en Georges\u2010Pompidou, INSERM UMR970, PARCC, Centre de R\u00e9f\u00e9rence des Maladies Vasculaires Rares, H\u00f4pitaux Universitaires Paris Ouest, and Universit\u00e9 Paris Descartes, Paris 5, Sorbonne Paris Cit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Resche\u2010Rigon","sequence":"additional","affiliation":[{"name":"AP\u2010HP, SBIM, H\u00f4pital Saint\u2010Louis and Universit\u00e9 Paris Diderot, Paris 7, INSERM, CRESS UMR\u2010S 1153 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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