{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:06:51Z","timestamp":1792670811867,"version":"4.5.0"},"reference-count":15,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,11,25]],"date-time":"2015-11-25T00:00:00Z","timestamp":1448409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Validated methods for the screening and early diagnosis of systemic sclerosis (SSc; scleroderma)\u2013related interstitial lung disease (ILD) are needed. The aim of this study was to evaluate the performance of pulmonary function tests (PFTs) compared with that of high\u2010resolution computed tomography (HRCT) of the chest for the detection of SSc\u2010related ILD in clinical practice, and to identify predictors of lung involvement that is functionally occult but significant on HRCT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospectively enrolled patients with SSc were assessed according to the European League Against Rheumatism (EULAR)\/EULAR Scleroderma Trial and Research standards. The assessment included PFTs and HRCT. The HRCT images were evaluated in a blinded manner by 2 experienced radiologists. The performance parameters of PFTs for the diagnosis of SSc\u2010related ILD were calculated. Predictors of significant ILD as determined by HRCT in patients with normal forced vital capacity (FVC) values were identified through logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the 102 patients, 64 (63.0%) showed significant ILD on HRCT, while only 27 (26.0%) had an FVC &lt;80% of predicted, and 54 (53.0%) had a decrease in the results of at least 1 PFT. Forty (62.5%) of 64 patients with significant ILD on HRCT had a normal FVC value, translating into a high false\u2010negative rate. Notably, 5 of 40 patients with a normal FVC value had severe, functionally occult lung fibrosis; in 2 of these patients, the results of all of the PFTs were within normal limits. Patients with normal FVC values despite evidence of fibrosis on HRCT more frequently had anti\u2013Scl\u201070 antibodies and diffuse SSc and less frequently had anticentromere antibodies (ACAs) compared with patients with both normal FVC values and normal HRCT results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The derived evidence\u2010based data reveal a high risk of missing significant SSc\u2010related ILD when relying solely on PFTs. More comprehensive screening algorithms for early detection are warranted. In particular, additional imaging investigations for the early detection of SSc\u2010related ILD should be considered in ACA\u2010negative patients with normal FVC values.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.39405","type":"journal-article","created":{"date-parts":[[2015,8,28]],"date-time":"2015-08-28T10:49:24Z","timestamp":1440758964000},"page":"3256-3261","source":"Crossref","is-referenced-by-count":205,"title":["Brief Report: Pulmonary Function Tests: High Rate of False\u2010Negative Results in the Early Detection and Screening of Scleroderma\u2010Related Interstitial Lung Disease"],"prefix":"10.1002","volume":"67","author":[{"given":"Yossra A.","family":"Suliman","sequence":"first","affiliation":[{"name":"University Hospital Zurich, Zurich, Switzerland, and Assiut University Hospital Assiut Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rucsandra","family":"Dobrota","sequence":"additional","affiliation":[{"name":"University Hospital Zurich, Zurich, Switzerland, and Dr. I. Cantacuzino Hospital and Carol Davila University of Medicine and Pharmacy Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00f6rte","family":"Huscher","sequence":"additional","affiliation":[{"name":"German Rheumatism Research Centre and Charit\u00e9 University Hospital Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi D. L.","family":"Nguyen\u2010Kim","sequence":"additional","affiliation":[{"name":"University Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britta","family":"Maurer","sequence":"additional","affiliation":[{"name":"University Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzana","family":"Jordan","sequence":"additional","affiliation":[{"name":"University Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf","family":"Speich","sequence":"additional","affiliation":[{"name":"University Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Frauenfelder","sequence":"additional","affiliation":[{"name":"University Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Distler","sequence":"additional","affiliation":[{"name":"University Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.114264"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21583"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200706-877OC"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1371541"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2013-204202"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230510"},{"key":"e_1_2_7_8_1","unstructured":"American College of Radiology.ACR practice guideline for the performance of high\u2010resolution computed tomography (HRCT) of the lungs in adults. Revised 2010 (Resolution 43). URL:http:\/\/doseoptimization.jacr.org\/Content\/PDF\/Lungs.pdf."},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034805"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-0630"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.091710"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes289"},{"key":"e_1_2_7_13_1","first-page":"22","article-title":"Assessments of pulmonary involvement in patients with systemic sclerosis","volume":"14","author":"Gohari Moghadam K","year":"2011","journal-title":"Arch Iran Med"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.189.3.8234692"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201108-1420PP"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205637"}],"container-title":["Arthritis &amp; Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.39405","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.39405","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.39405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:37:26Z","timestamp":1759945046000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/art.39405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,25]]},"references-count":15,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1002\/art.39405"],"URL":"https:\/\/doi.org\/10.1002\/art.39405","archive":["Portico"],"relation":{},"ISSN":["2326-5191","2326-5205"],"issn-type":[{"value":"2326-5191","type":"print"},{"value":"2326-5205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,25]]}}}