{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T07:56:01Z","timestamp":1791705361635,"version":"4.3.4"},"reference-count":23,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,11,25]],"date-time":"2015-11-25T00:00:00Z","timestamp":1448409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH (National Institute of Arthritis and Musculoskeletal and Skin Diseases)","award":["P60-AR-47785"],"award-info":[{"award-number":["P60-AR-47785"]}]},{"name":"Multicenter Osteoarthritis Study","award":["U01-AG-18820"],"award-info":[{"award-number":["U01-AG-18820"]}]},{"name":"Multicenter Osteoarthritis Study","award":["U01-AG-18832"],"award-info":[{"award-number":["U01-AG-18832"]}]},{"name":"Multicenter Osteoarthritis Study","award":["U01-AG-18947"],"award-info":[{"award-number":["U01-AG-18947"]}]},{"name":"Multicenter Osteoarthritis Study","award":["U01-AG-19079"],"award-info":[{"award-number":["U01-AG-19079"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To identify patterns of coexisting lesions seen on magnetic resonance imaging (MRI) in knees that are free of radiographic osteoarthritis (OA) and to examine the relationship of these MRI\u2010detected lesions to incident OA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Study subjects were individuals enrolled in the Multicenter Osteoarthritis Study, a prospective cohort study. In each subject, 1 knee in which radiographic OA was absent in both the tibiofemoral and patellofemoral joints at baseline was selected for study, with followup for 84 months. We used a novel approach, latent class analysis, to group the constellation of MRI lesions in each joint, i.e., cartilage damage, bone marrow lesion, meniscal tear, meniscal extrusion, synovitis, and effusion, into a manageable number of subgroups. The association of these subgroups with incident radiographic OA in the same joint was assessed using logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 885 eligible knees (203 with incident disease in the tibiofemoral joint, 64 with incident disease in the patellofemoral joint), 4 latent subgroups in the tibiofemoral joint were identified (described briefly as minimal lesions, mild lesions, moderate lesions [but limited meniscal lesions], and severe lesions). The odds ratios of incident tibiofemoral joint OA in the latter 3 subgroups (compared to the knees with minimal lesions as the referent) were 5.6, 1.8, and 5.0, respectively. A similar set of 4 subgroups in the patellofemoral joint was identified, except that the fourth subgroup had limited meniscal lesions. The odds ratios of incident disease in the patellofemoral joint were 3.8, 5.1, and 13.7 in the subgroups with mild lesions, moderate lesions, and severe lesions, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Different patterns of coexisting MRI lesions, which have different implications with regard to risk of knee OA, were identified. Meniscal damage seemed to play a different role in the development of incident disease in tibiofemoral versus patellofemoral joints.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.39436","type":"journal-article","created":{"date-parts":[[2015,9,28]],"date-time":"2015-09-28T12:48:40Z","timestamp":1443444520000},"page":"3158-3165","source":"Crossref","is-referenced-by-count":29,"title":["Patterns of Coexisting Lesions Detected on Magnetic Resonance Imaging and Relationship to Incident Knee Osteoarthritis: The Multicenter Osteoarthritis Study"],"prefix":"10.1002","volume":"67","author":[{"given":"Jingbo","family":"Niu","sequence":"first","affiliation":[{"name":"Boston University School of Medicine Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David T.","family":"Felson","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine, Boston, Massachusetts, and University of Manchester Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuhina","family":"Neogi","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Nevitt","sequence":"additional","affiliation":[{"name":"University of California San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Guermazi","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine and Boston Core Imaging Lab, LLC Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Roemer","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine and Boston Core Imaging Lab, LLC, Boston, Massachusetts, and University of Erlangen\u2013Nuremberg Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cora E.","family":"Lewis","sequence":"additional","affiliation":[{"name":"University of Alabama School of Medicine Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Torner","sequence":"additional","affiliation":[{"name":"University of Iowa Iowa City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.60.2.91"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204763"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.11101359"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38611"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24383"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2011.150243"},{"key":"e_1_2_6_8_1","article-title":"Synovitis in knee osteoarthritis: a precursor of disease?","author":"Atukorala I","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.knee.2006.01.005"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kws412"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22213"},{"key":"e_1_2_6_12_1","first-page":"2047","article-title":"A new approach yields high rates of radiographic progression in knee osteoarthritis","volume":"35","author":"Felson DT","year":"2008","journal-title":"J Rheumatol"},{"key":"e_1_2_6_13_1","first-page":"S361","article-title":"Nonfluoroscopic method for flexed radiography of the knee that allows reproducible joint\u2010space width measurement [abstract]","volume":"41","author":"Peterfy CG","year":"1998","journal-title":"Arthritis Rheum"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-004-2312-6"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.16.4.494"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1063-4584(97)80020-9"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.096834"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2003.11.003"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/10705510701575602"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02294360"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.4159\/9780674041318"},{"key":"e_1_2_6_22_1","unstructured":"LanzaST TanX BrayBC.A technical introduction: a model\u2010based approach to latent class analysis with distal outcomes. 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