{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T04:04:29Z","timestamp":1793678669575,"version":"4.5.1"},"reference-count":52,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,2,24]],"date-time":"2016-02-24T00:00:00Z","timestamp":1456272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Hospices Civils de Lyon (D\u00e9l\u00e9gation \u00e0 la Recherche Clinique, Lyon, France, Trial no. 97.129)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p><jats:bold> Findings from the WEGENT trial<\/jats:bold> <jats:bold>and other short\u2010term studies have suggested that azathioprine (AZA) or methotrexate (MTX) could effectively maintain remission of granulomatosis with polyangiitis (Wegener's) (GPA) or microscopic polyangiitis (MPA). This study was undertaken to examine whether differences in rates of relapse or adverse events would appear after discontinuation of these 2 maintenance regimens, when assessed over a longer followup period.<\/jats:bold><\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Long\u2010term outcomes in patients enrolled in the WEGENT trial were analyzed according to their randomized treatment group (AZA or MTX). Parameters at trial entry were evaluated as potential prognostic factors for death, relapse, or damage in multivariate models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:bold> Data from 10 years of followup were available for 112 (88.8%) of the 126 original trial participants. The median followup time was 11.9 years (95% confidence interval [95% CI] 11.3\u201312.5 years).<\/jats:bold> <jats:bold>In patients receiving AZA and those receiving MTX, the 10\u2010year overall survival rates were 75.1% (95% CI 64.8\u201386.9%) and 79.9% (95% CI 70.3\u201390.8%) (<jats:italic>P<\/jats:italic>\u2009=\u20090.56), respectively, and relapse\u2010free survival rates were 26.3% (95% CI 17.3\u201340.1%) and 33.5% (95% CI 23.5\u201347.7%) (<jats:italic>P<\/jats:italic>\u2009=\u20090.29), respectively. No between\u2010treatment differences were observed with regard to rates of relapse, adverse events, damage, survival without severe side effects, and survival without relapse and severe side effects. In analyses limited to the 97 patients with GPA, no between\u2010treatment differences in survival rates were observed. The 10\u2010year relapse\u2010free survival rate was lower<\/jats:bold> <jats:bold>in patients with GPA than in patients with MPA. However, in the multivariate analysis, anti\u2013proteinase 3 antineutrophil cytoplasmic antibody (ANCA) positivity, and not GPA, was retained as being independently associated with the relapse rate.<\/jats:bold><\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results of this long\u2010term analysis confirm that AZA and MTX are comparable treatment options for maintaining remission of GPA or MPA. Despite achieving good overall survival with these treatments, relapse rates, adverse events, and damage remain matters of concern and further studies are needed to reduce their frequency in these ANCA\u2010associated vasculitides.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.39450","type":"journal-article","created":{"date-parts":[[2015,10,16]],"date-time":"2015-10-16T15:58:56Z","timestamp":1445011136000},"page":"690-701","source":"Crossref","is-referenced-by-count":115,"title":["Long\u2010Term Outcomes Among Participants in the WEGENT Trial of Remission\u2010Maintenance Therapy for Granulomatosis With Polyangiitis (Wegener's) or Microscopic Polyangiitis"],"prefix":"10.1002","volume":"68","author":[{"given":"Xavier","family":"Pu\u00e9chal","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Descartes and H\u00f4pital Cochin AP\u2010HP Paris 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