{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:30:21Z","timestamp":1786977021440,"version":"build-2736575974"},"reference-count":60,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,3,28]],"date-time":"2016-03-28T00:00:00Z","timestamp":1459123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Health and Medical Research Council of Australia"},{"name":"DFG","award":["CH 818\/1-1 and CH 818\/1-2"],"award-info":[{"award-number":["CH 818\/1-1 and CH 818\/1-2"]}]},{"DOI":"10.13039\/501100003390","name":"Fritz Thyssen Foundation","doi-asserted-by":"crossref","award":["20.13.0.114"],"award-info":[{"award-number":["20.13.0.114"]}],"id":[{"id":"10.13039\/501100003390","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Antibody\u2010mediated autoimmunity involves cognate interactions between self\u2010reactive T cells and B cells during germinal center (GC) reactions. The aim of this study was to determine the role of essential follicular helper T (Tfh) cell molecules (CXCR5, signaling lymphocytic activation molecule\u2013associated protein) on autoreactive CD4+ cells and the role of certain environmental influences that may determine GC\u2010driven autoantibody production and arthritis development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We transferred self\u2010reactive CD4+ cells from KRN\u2010Tg mice into recipient mice, which induced autoantibodies and autoinflammatory arthritis. This model allowed manipulation of environmental effects, such as inflammation, and use of transferred cells that were genetically deficient in important Tfh cell\u2013associated molecules.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A deficiency of signaling lymphocytic activation molecule\u2013associated protein (SAP) in CD4+ cells from KRN\u2010Tg mice completely protected against arthritis, indicating that stable T cell\u2013B cell interactions are required for GC formation, autoantibody production, and arthritis induction. In contrast, a CXCR5 deficiency in CD4+ cells from KRN\u2010Tg mice still induced disease when these cells were transferred into wild\u2010type mice, suggesting that T cell help for B cells could rely on other migration mechanisms. However, various manipulations influenced this system, including elimination of bystander effects through use of CD28\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      recipient mice (reduced disease) or use of inflammation\u2010inducing Freund's complete adjuvant (progression to arthritis). We also examined the capacity of preexisting GCs with a nonautoimmune specificity to co\u2010opt autoimmune T cells and observed no evidence for any influence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In addition to the quality and quantity of cognate CD4+ cell help, external factors such as inflammation and noncognate CD4+ cell bystander activation trigger autoimmunity by shaping events within autoimmune GC responses. SAP is an essential molecule for autoimmune antibody production, whereas the importance of CXCR5 varies depending on the circumstances.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.39481","type":"journal-article","created":{"date-parts":[[2015,10,26]],"date-time":"2015-10-26T11:37:26Z","timestamp":1445859446000},"page":"1026-1038","source":"Crossref","is-referenced-by-count":27,"title":["The Role of Follicular Helper T Cell Molecules and Environmental Influences in Autoantibody Production and Progression to Inflammatory Arthritis in Mice"],"prefix":"10.1002","volume":"68","author":[{"given":"Nina","family":"Chevalier","sequence":"first","affiliation":[{"name":"University Medical Centre Freiburg, Freiburg, Germany, Monash University, Clayton Campus, Melbourne, Victoria, Australia, and Garvan Institute of Medical Research Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Macia","sequence":"additional","affiliation":[{"name":"Monash University, Clayton Campus, Melbourne, Victoria, Australia, and Charles Perkins Centre, University of Sydney Camperdown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian K.","family":"Tan","sequence":"additional","affiliation":[{"name":"Monash University, Clayton Campus Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda J.","family":"Mason","sequence":"additional","affiliation":[{"name":"Monash University, Clayton Campus Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remy","family":"Robert","sequence":"additional","affiliation":[{"name":"Monash University, Clayton Campus Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison N.","family":"Thorburn","sequence":"additional","affiliation":[{"name":"Monash University, Clayton Campus Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connie H. Y.","family":"Wong","sequence":"additional","affiliation":[{"name":"Monash University, Clayton Campus Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis M.","family":"Tsai","sequence":"additional","affiliation":[{"name":"Monash University, Clayton Campus Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Bourne","sequence":"additional","affiliation":[{"name":"Garvan Institute of Medical Research Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Brink","sequence":"additional","affiliation":[{"name":"Garvan Institute of Medical Research Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Yu","sequence":"additional","affiliation":[{"name":"Monash University, Clayton Campus Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles R.","family":"Mackay","sequence":"additional","affiliation":[{"name":"Monash University, Clayton Campus Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2637"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1714"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.1.68"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.26.021607.090344"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.11.1553"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.11.1545"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.190.8.1123"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002828"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01318"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07345"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200106)44:6<1438::AID-ART239>3.0.CO;2-Q"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.10.019"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.06.001"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.12-226951"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200636486"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.8.5099"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-11-4494"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20131666"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2012.07.011"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1302966"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1160"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901690"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20060087"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80045-X"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5445.1732"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0912152106"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201343811"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7688139"},{"key":"e_1_2_8_30_1","doi-asserted-by":"crossref","first-page":"4576","DOI":"10.4049\/jimmunol.156.12.4576","article-title":"CD28 is required for germinal center formation","volume":"156","author":"Ferguson SE","year":"1996","journal-title":"J Immunol"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12058"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni947"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.182.3.1421"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.8.4332"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.119164"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/89750"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03555"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0709517"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2008.07.014"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.70.6.849"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)00004-7"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-030409-101302"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-11-395913"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-009-0193-0"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364453"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.205"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.10.009"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20101653"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.6.2848"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.6.3659"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/35051113"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/35051107"},{"key":"e_1_2_8_53_1","first-page":"1:167","article-title":"The costimulatory molecule ICOS regulates the expression of c\u2010Maf and IL\u201021 in the development of follicular T helper cells and TH\u201017 cells","author":"Bauquet AT","year":"2009","journal-title":"Nat Immunol"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203309360670"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.68.4.447"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.10.010"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0030150"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20091225"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05573"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1036"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1556\/EuJMI.1.2011.3.3"}],"container-title":["Arthritis &amp; Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.39481","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.39481","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T20:04:00Z","timestamp":1759953840000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/art.39481"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,28]]},"references-count":60,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1002\/art.39481"],"URL":"https:\/\/doi.org\/10.1002\/art.39481","archive":["Portico"],"relation":{},"ISSN":["2326-5191","2326-5205"],"issn-type":[{"value":"2326-5191","type":"print"},{"value":"2326-5205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,28]]}}}