{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T21:31:45Z","timestamp":1774128705951,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,2,24]],"date-time":"2016-02-24T00:00:00Z","timestamp":1456272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH","award":["U54-GM-104938"],"award-info":[{"award-number":["U54-GM-104938"]}]},{"name":"NIH","award":["P30-AR-053483"],"award-info":[{"award-number":["P30-AR-053483"]}]},{"name":"NIH","award":["P30-GM-103510"],"award-info":[{"award-number":["P30-GM-103510"]}]},{"name":"NIH","award":["U19-AI-082714"],"award-info":[{"award-number":["U19-AI-082714"]}]},{"name":"NIH","award":["P50-AR-060804"],"award-info":[{"award-number":["P50-AR-060804"]}]},{"DOI":"10.13039\/100008907","name":"Oklahoma Medical Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008907","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Autoantibodies reactive with Ro52 (tripartite motif\u2212containing protein 21 [TRIM21]) are detected in 70% of patients with primary Sj\u00f6gren's syndrome (SS). TRIM21 belongs to a 34\u2010member C\u2010IV family of TRIM proteins. Although autoantibodies against other TRIM proteins within the C\u2010IV family have been detected in the sera of patients with primary SS, their clinical relevance remains unclear. This study was undertaken to investigate the frequency of anti\u2010TRIM38 in patients with primary SS and evaluate its association with various clinical measures of the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serum samples from patients with primary SS (n\u2009=\u2009235) and controls (n\u2009=\u200950) were analyzed for reactivity with in vitro\u2212transcribed and \u2212translated <jats:sup>35<\/jats:sup>S\u2010methionine\u2212labeled TRIM38 protein. The associations of anti\u2010TRIM38 with various laboratory and clinical measures of primary SS were evaluated. Reactivity of anti\u2010TRIM38 with different structural domains of TRIM38 was analyzed. Affinity\u2010purified anti\u2010TRIM38 antibodies were used to immunoprecipitate TRIM21.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>TRIM38\u2010reactive autoantibodies were detected in the sera of 24 of the 235 patients with primary SS and 2 of the 50 controls. Anti\u2010TRIM38 positivity was significantly associated with the presence of anti\u2010Ro60, anti\u2010Ro52, anti\u2010La, rheumatoid factor, and hypergammaglobulinemia. Clinically, anti\u2010TRIM38 was associated with significantly higher ocular surface staining scores, lower Schirmer's test scores, and minor labial salivary gland biopsy focus scores of \u22653.0. Anti\u2010TRIM38 antibodies mainly recognized the cortactin\u2010binding protein 2 (CortBP\u20102; amino acids 128\u2013238) and the B30.2\/SPRY (amino acids 268\u2013465) domains on TRIM38. Affinity\u2010purified antibodies to TRIM38\u2013CortBP\u20102 and TRIM38\u2013B30.2\/SPRY domains reacted with TRIM21.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data demonstrate that anti\u2010TRIM38 specificity arising in a subset of patients with primary SS is associated with increased severity of the disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.39497","type":"journal-article","created":{"date-parts":[[2015,12,4]],"date-time":"2015-12-04T18:54:44Z","timestamp":1449255284000},"page":"724-729","source":"Crossref","is-referenced-by-count":23,"title":["Brief Report: Patients With Primary Sj\u00f6gren's Syndrome Who Are Positive for Autoantibodies to Tripartite Motif\u2013Containing Protein 38 Show Greater Disease Severity"],"prefix":"10.1002","volume":"68","author":[{"given":"Nina","family":"Wolska","sequence":"first","affiliation":[{"name":"Oklahoma Medical Research Foundation Oklahoma City"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulina","family":"Rybakowska","sequence":"additional","affiliation":[{"name":"Oklahoma Medical Research Foundation Oklahoma City"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astrid","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Oklahoma Medical Research Foundation Oklahoma City"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Brown","sequence":"additional","affiliation":[{"name":"Oklahoma Medical Research Foundation Oklahoma City"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Courtney","family":"Montgomery","sequence":"additional","affiliation":[{"name":"Oklahoma Medical Research Foundation Oklahoma City"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arkadiusz","family":"Klopocki","sequence":"additional","affiliation":[{"name":"Oklahoma Medical Research Foundation Oklahoma City"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiely","family":"Grundahl","sequence":"additional","affiliation":[{"name":"Oklahoma Medical Research Foundation Oklahoma City"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert H.","family":"Scofield","sequence":"additional","affiliation":[{"name":"Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, and VAMC Oklahoma City"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lida","family":"Radfar","sequence":"additional","affiliation":[{"name":"University of Oklahoma College of Dentistry Oklahoma City"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald U.","family":"Stone","sequence":"additional","affiliation":[{"name":"University of Oklahoma Health Sciences Center Oklahoma City"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan M.","family":"Anaya","sequence":"additional","affiliation":[{"name":"Universidad del Rosario Bogota Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Ice","sequence":"additional","affiliation":[{"name":"Oklahoma Medical Research Foundation Oklahoma City"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher J.","family":"Lessard","sequence":"additional","affiliation":[{"name":"Oklahoma Medical Research Foundation Oklahoma City"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Lewis","sequence":"additional","affiliation":[{"name":"University of Oklahoma College of Dentistry Oklahoma City"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelson L.","family":"Rhodus","sequence":"additional","affiliation":[{"name":"University of Minnesota School of Dentistry Minneapolis"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajaram","family":"Gopalakrishnan","sequence":"additional","affiliation":[{"name":"University of Minnesota School of Dentistry Minneapolis"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J. W.","family":"Huang","sequence":"additional","affiliation":[{"name":"Washington University St. Louis  Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela J.","family":"Hughes","sequence":"additional","affiliation":[{"name":"University of Minnesota School of Dentistry Minneapolis"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael D.","family":"Rohrer","sequence":"additional","affiliation":[{"name":"University of Minnesota School of Dentistry Minneapolis"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael H.","family":"Weisman","sequence":"additional","affiliation":[{"name":"Cedars\u2010Sinai Medical Center Los Angeles  California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swamy","family":"Venuturupalli","sequence":"additional","affiliation":[{"name":"Cedars\u2010Sinai Medical Center Los Angeles  California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel M.","family":"Guthridge","sequence":"additional","affiliation":[{"name":"Oklahoma Medical Research Foundation Oklahoma City"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith A.","family":"James","sequence":"additional","affiliation":[{"name":"Oklahoma Medical Research Foundation and University of Oklahoma Health Sciences Center Oklahoma City"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathy L.","family":"Sivils","sequence":"additional","affiliation":[{"name":"Oklahoma Medical Research Foundation Oklahoma City"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harini","family":"Bagavant","sequence":"additional","affiliation":[{"name":"Oklahoma Medical Research Foundation Oklahoma City"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umesh S.","family":"Deshmukh","sequence":"additional","affiliation":[{"name":"Oklahoma Medical Research Foundation Oklahoma City"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-012513-104728"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2013.11.001"},{"key":"e_1_2_7_4_1","article-title":"Interaction between innate immunity and Ro52\u2010induced antibody causes Sj\u00f6gren's syndrome\u2010like disorder in mice","author":"Szczerba BM","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/08916934.2012.732131"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.10.6277"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-5398-7_1"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200113469"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2002.01417.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.6.554"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203845"},{"key":"e_1_2_7_12_1","first-page":"686","article-title":"Anti\u2010Ro52 antibody testing influences the classification and clinical characterisation of primary Sj\u00f6gren's syndrome","volume":"30","author":"Retamozo S","year":"2012","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1318227111"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046825"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2012.01.014"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-11-93"}],"container-title":["Arthritis &amp; Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.39497","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.39497","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:53:00Z","timestamp":1759945980000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/art.39497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,24]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1002\/art.39497"],"URL":"https:\/\/doi.org\/10.1002\/art.39497","archive":["Portico"],"relation":{},"ISSN":["2326-5191","2326-5205"],"issn-type":[{"value":"2326-5191","type":"print"},{"value":"2326-5205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,24]]}}}