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Associations of cholesterol changes with disease activity and drug treatment were evaluated using repeated\u2010measures analysis with mixed\u2010effect linear models to model within\u2010subject covariance over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mixed\u2010effect models controlling for traditional cardiovascular (CV) risk factors, TEAR treatment, and baseline prednisone and statin use demonstrated significant inverse associations of RA disease activity with changes in cholesterol over time. Decreases in the 28\u2010joint Disease Activity Score, the C\u2010reactive protein level, or the erythrocyte sedimentation rate were associated with increases in levels of HDL cholesterol, LDL cholesterol, and total cholesterol in all treatment groups (<jats:italic>P<\/jats:italic> &lt; 0.001\u20130.035). Triple therapy was strongly associated with higher levels of HDL cholesterol, lower levels of LDL cholesterol, and higher ratios of total cholesterol:HDL cholesterol (<jats:italic>P<\/jats:italic> &lt; 0.001 for all) compared to MTX monotherapy or MTX plus etanercept therapy over the 2\u2010year followup.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Decreases in RA disease activity over long\u2010term followup were associated with increases in cholesterol levels in patients with early RA treated with either biologic or nonbiologic therapies. The use of triple therapy during 2 years of followup was associated with higher HDL cholesterol levels, lower LDL cholesterol levels, and lower total cholesterol:HDL cholesterol ratios compared to those observed in patients who received MTX monotherapy or MTX plus etanercept combination therapy. Additional studies are needed to assess the effects of these cholesterol changes on CV events in patients with RA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.39502","type":"journal-article","created":{"date-parts":[[2015,11,25]],"date-time":"2015-11-25T11:25:44Z","timestamp":1448450744000},"page":"577-586","source":"Crossref","is-referenced-by-count":40,"title":["Association of Triple Therapy With Improvement in Cholesterol Profiles Over Two\u2010Year Followup in the Treatment of Early Aggressive Rheumatoid Arthritis Trial"],"prefix":"10.1002","volume":"68","author":[{"given":"Christina","family":"Charles\u2010Schoeman","sequence":"first","affiliation":[{"name":"University of California Los Angeles"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Wang","sequence":"additional","affiliation":[{"name":"University of California Los Angeles"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuen 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Birmingham"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larry W.","family":"Moreland","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"O'Dell","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center Omaha"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan M.","family":"Bathon","sequence":"additional","affiliation":[{"name":"Columbia University New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harold","family":"Paulus","sequence":"additional","affiliation":[{"name":"University of California Los Angeles"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"S.","family":"Louis Bridges","sequence":"additional","affiliation":[{"name":"University of Alabama at 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