{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T23:57:13Z","timestamp":1790639833496,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,3,28]],"date-time":"2016-03-28T00:00:00Z","timestamp":1459123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Dutch Arthritis Foundation (Reumafonds) and by The Netherlands Organization for Scientific Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      The prevalence of periodontitis is increased in patients with rheumatoid arthritis (RA), and the severity of periodontitis can affect the level of arthritis.\n                      <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                      is one of the main bacteria involved in periodontitis. Our aim was to determine if there are differences in the innate immune response against\n                      <jats:italic>P gingivalis<\/jats:italic>\n                      between healthy controls and RA patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Monocyte\u2010derived dendritic cells (DCs) from healthy controls, RA patients, and patients with psoriatic arthritis (PsA) were stimulated with\n                      <jats:italic>P gingivalis<\/jats:italic>\n                      , a range of other bacteria, and Toll\u2010like receptor agonists. Cytokine production was determined, and blocking studies were performed to determine which receptors were involved in differential recognition of\n                      <jats:italic>P gingivalis<\/jats:italic>\n                      . Effects on T cell cytokines were also determined in cultures of peripheral blood mononuclear cells (PBMCs).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Upon stimulation with\n                      <jats:italic>P gingivalis<\/jats:italic>\n                      , RA patient DCs produced less tumor necrosis factor as compared to healthy control DCs, which was not observed in PsA patients or upon stimulation with other bacteria. In addition,\n                      <jats:italic>P gingivalis<\/jats:italic>\n                      \u2013mediated activation of RA patient PBMCs showed a clear reduction of interferon\u2010\u03b3 production. Among the various possible underlying mechanisms investigated, only blockade of CR3 abolished the difference between RA patients and healthy controls, suggesting the involvement of CR3 in this process.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Immune cells from RA patients display a reduced response to\n                      <jats:italic>P gingivalis<\/jats:italic>\n                      , which has functional consequences for the immune response. This may result in prolonged survival of\n                      <jats:italic>P gingivalis<\/jats:italic>\n                      , possibly driving autoantibody formation and a self\u2010perpetuating loop of chronic inflammation. The possible role of CR3 in this process warrants further investigation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.39514","type":"journal-article","created":{"date-parts":[[2015,11,25]],"date-time":"2015-11-25T11:26:25Z","timestamp":1448450785000},"page":"795-804","source":"Crossref","is-referenced-by-count":16,"title":["Impaired\n                    <i>Porphyromonas gingivalis<\/i>\n                    \u2013Induced Tumor Necrosis Factor Production by Dendritic Cells Typifies Patients With Rheumatoid Arthritis"],"prefix":"10.1002","volume":"68","author":[{"given":"Kim C. M.","family":"Santegoets","sequence":"first","affiliation":[{"name":"University Medical Center Utrecht, Utrecht, The Netherlands, and Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark H.","family":"Wenink","sequence":"additional","affiliation":[{"name":"University Medical Center Utrecht, Utrecht, The Netherlands, and Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe A. Vieira","family":"Braga","sequence":"additional","affiliation":[{"name":"Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Cossu","sequence":"additional","affiliation":[{"name":"University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Femke B. 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