{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T14:45:15Z","timestamp":1792507515390,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,3,28]],"date-time":"2016-03-28T00:00:00Z","timestamp":1459123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To define parameters predictive of lymphoma development in patients with primary Sj\u00f6gren's syndrome (SS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A multicenter case\u2013control survey was performed to identify predictors of lymphoma. Cases were patients who developed lymphoma after diagnosis of primary SS and were mainly recruited through the Club Rhumatismes et Inflammation network. For each case, 2 controls (matched for disease duration and age) were randomly selected among patients with primary SS and without lymphoma. Cases and controls were compared using univariate analysis and then using multivariate analysis to identify independent predictors of lymphoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:bold>One hundred one patients with primary SS and lymphoma were included. Eighty\u2010seven patients were women (86.1%), and the mean\u2009\u00b1\u2009SD age at lymphoma diagnosis was 57.4\u2009\u00b1\u200912.6 years. The most frequent histologic type was B cell non\u2010Hodgkin's lymphoma (NHL) in 99 of 101 patients, with marginal\u2010zone lymphoma in 76 of the 99 patients (76.8%) including 58 (58.6%) with lymphoma of the mucosa\u2010associated lymphoid tissue type. Lymphomas were most frequently located in the salivary glands (43 patients). A specific treatment was initiated at diagnosis in 87 patients with B cell NHL, and 61 patients (61.6%) achieved complete sustained remission after the first line of treatment.<\/jats:bold>\n                      <jats:bold>In the multivariate analysis, salivary gland enlargement, the presence of rheumatoid factor (RF), low C4, cryoglobulinemia, lymphopenia, and disease activity according to the European League Against Rheumatism Sj\u00f6gren's Syndrome Disease Activity Index (excluding the lymphoma domain) were found to be predictors of lymphoma. No previous treatment for primary SS was associated with any effect on lymphoma occurrence.<\/jats:bold>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In addition to previously known factors predictive of lymphoma occurrence, the independent roles of RF and disease activity were demonstrated in this case\u2013control study of primary SS\u2013associated lymphoma. Our findings highlight the roles of chronic antigenic stimulation and disease activity in the development of this severe complication.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.39518","type":"journal-article","created":{"date-parts":[[2015,11,25]],"date-time":"2015-11-25T11:27:01Z","timestamp":1448450821000},"page":"977-985","source":"Crossref","is-referenced-by-count":195,"title":["Rheumatoid Factor and Disease Activity Are Independent Predictors of Lymphoma in Primary Sj\u00f6gren's Syndrome"],"prefix":"10.1002","volume":"68","author":[{"given":"G.","family":"Nocturne","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris\u2010Sud, INSERM U1184 Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Virone","sequence":"additional","affiliation":[{"name":"AP\u2010HP, H\u00f4pitaux Universitaires Paris\u2010Sud Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan\u2010Fai","family":"Ng","sequence":"additional","affiliation":[{"name":"Newcastle University Newcastle\u2010upon\u2010Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Le Guern","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Descartes and AP\u2010HP, H\u00f4pital Cochin Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Hachulla","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Lille 2 Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Cornec","sequence":"additional","affiliation":[{"name":"Centre Hospitalier R\u00e9gional Universitaire (CHRU) de Brest, H\u00f4pital de la Cavale Blanche and EA 2216, INSERM ESPRI, ERI29, Universit\u00e9 de Brest Brest France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Daien","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire (CHU) de Montpellier and URM5535 CNRS Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Vittecoq","sequence":"additional","affiliation":[{"name":"CHU de Rouen, INSERM U905, and Universit\u00e9 de Rouen Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Bienvenu","sequence":"additional","affiliation":[{"name":"CHU de Caen, H\u00f4pital de la C\u00f4te de Nacre Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Marcelli","sequence":"additional","affiliation":[{"name":"CHU de Caen, H\u00f4pital de la C\u00f4te de Nacre Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Wendling","sequence":"additional","affiliation":[{"name":"CHRU Besan\u00e7on, and EA 4266, Universit\u00e9 de Franche\u2010Comt\u00e9 Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Amoura","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Pierre et Marie Curie and AP\u2010HP, H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Dhote","sequence":"additional","affiliation":[{"name":"CHU Avicenne Bobigny France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Lavigne","sequence":"additional","affiliation":[{"name":"CHU Angers Angers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Fior","sequence":"additional","affiliation":[{"name":"AP\u2010HP, H\u00f4pital B\u00e9cl\u00e8re Clamart France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. E.","family":"Gottenberg","sequence":"additional","affiliation":[{"name":"INSERM UMR-S 1109, CHRU Strasbourg, and Universit\u00e9 de Strasbourg Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Seror","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2010Sud, INSERM U1184, and AP\u2010HP, H\u00f4pitaux Universitaires Paris\u2010Sud Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Mariette","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2010Sud, INSERM U1184, and AP\u2010HP, H\u00f4pitaux Universitaires Paris\u2010Sud Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.20.2337"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu365"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21887"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djj004"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200402"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.041186"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/sarh.2002.32557"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2011.04.006"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780390508"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.6.554"},{"key":"e_1_2_6_12_1","volume-title":"WHO classification of tumours of haematopoietic and lymphoid tissues","author":"Swerdlow SH","year":"2008"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.110619"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204615"},{"key":"e_1_2_6_15_1","unstructured":"MeinersP MarietteX BaronG VitaliC BowmanS GottenbergJE et al. D\u00e9veloppement d'un score ClinESSDAI (EULAR Sj\u00f6gren's Syndrome Disease Activity Index) sans domaine biologique: un outil pour les \u00e9tudes biologiques. In: Proceedings of the Congress of the Soci\u00e9t\u00e9 Fran\u00e7aise de Rhumatologie;2014. p.49."},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-eular.4399"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059868"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-0172(00)80016-5"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e3181b76ab5"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199908)42:8<1765::AID-ANR28>3.0.CO;2-V"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2013.04.004"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.2.766"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13192"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61763-2"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21856"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.40.6272"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-011-9553-3"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2013.10.002"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-014-3051-x"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200004)43:4<908::AID-ANR24>3.0.CO;2-K"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050068"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39002"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-eular.5008"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0116189"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.7682"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1177\/096120339600500108"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.52.5.360"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203933"}],"container-title":["Arthritis &amp; Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.39518","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.39518","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T20:03:56Z","timestamp":1759953836000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/art.39518"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,28]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1002\/art.39518"],"URL":"https:\/\/doi.org\/10.1002\/art.39518","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725960844.793519359","asserted-by":"object"}]},"ISSN":["2326-5191","2326-5205"],"issn-type":[{"value":"2326-5191","type":"print"},{"value":"2326-5205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,28]]}}}