{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T14:59:03Z","timestamp":1781017143784,"version":"3.54.1"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,4,27]],"date-time":"2016-04-27T00:00:00Z","timestamp":1461715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine whether thigh muscle strength predicts the risk of undergoing knee replacement surgery, independent of radiographic severity of osteoarthritis and pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants in the Osteoarthritis Initiative study who had received a knee replacement between the 12\u2010month and 60\u2010month follow\u2010up visits (cases) were each matched with 1 control subject (who did not receive a knee replacement over 60 months) for age, sex, height, body mass index, baseline radiographic stage, and location of joint space narrowing. Isometric knee extensor and flexor strength was recorded biennially. The strength examination prior to knee replacement (\u22642 years) was termed time 0, that 2 years prior to time 0 was termed time \u22122, and that 4 years prior to time 0 was termed time \u22124. Muscle strength in patients and controls was compared using paired <jats:italic>t<\/jats:italic>\u2010tests and conditional logistic regression analysis adjusted for pain.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>. One hundred thirty\u2010six participants (60% women, mean\u2009\u00b1\u2009SD age 65\u2009\u00b1\u20099 years, body mass index 29\u2009\u00b1\u20094 kg\/m<jats:sup>2<\/jats:sup>) received a knee replacement during follow\u2010up, had strength data for at least time 0, and had a matched control. Knee extensor strength at time 0 (primary outcome measure) was significantly lower in female patients compared with controls (<jats:italic>P<\/jats:italic> &lt; 0.001, pain\u2010adjusted odds ratio [OR<jats:sub>adj<\/jats:sub>] 1.72, 95% confidence interval 1.16\u20132.56), but no significant difference was observed in men. Results were similar for knee flexor strength at time 0 and for longitudinal change in extensor and flexor strength between time \u22122 and time 0. Thigh muscle strength at time \u22122 or time \u22124, or change between time \u22124 and time \u22122, did not predict the risk of undergoing knee replacement surgery in men or women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Thigh muscle strength predicted the risk of undergoing knee replacement surgery in women, but not in men. The results of this study may identify a window during which the risk of undergoing knee replacement surgery in women can be modified.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.39540","type":"journal-article","created":{"date-parts":[[2015,12,14]],"date-time":"2015-12-14T10:55:53Z","timestamp":1450090553000},"page":"1145-1155","source":"Crossref","is-referenced-by-count":36,"title":["Thigh Muscle Strength Predicts Knee Replacement Risk Independent of Radiographic Disease and Pain in Women: Data From the Osteoarthritis Initiative"],"prefix":"10.1002","volume":"68","author":[{"given":"Adam G.","family":"Culvenor","sequence":"first","affiliation":[{"name":"Institute of Anatomy, Paracelsus Medical University, Salzburg, Austria, and La Trobe University, Bundoora Campus Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Wirth","sequence":"additional","affiliation":[{"name":"Paracelsus Medical University Salzburg, Austria, and 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