{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T21:19:26Z","timestamp":1784841566804,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,4,27]],"date-time":"2016-04-27T00:00:00Z","timestamp":1461715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p><jats:bold> To examine how pre\u2010pregnancy body mass index (BMI), parity, and pregnancy\u2010related weight changes are associated with long\u2010term risk of degenerative<\/jats:bold> <jats:bold>musculoskeletal conditions.<\/jats:bold><\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:bold> A total of 79,687 mothers with singleton births from the Danish National Birth Cohort were included. Information on height and weight prior to pregnancy and 6 months postpartum as well as gestational weight gain (GWG) was obtained from telephone interviews, while parity was derived from the Danish Medical Birth Registry. Diagnoses of musculoskeletal conditions, including osteoarthritis, disc disorders, low back pain, and soft tissue disorders, were obtained from the Danish National Patient Registry. Hazard ratios (HRs) were estimated using a<\/jats:bold> <jats:bold>Cox proportional hazards regression model.<\/jats:bold><\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cumulative incidence of musculoskeletal conditions during a median follow\u2010up of 12.4 years was 19.7%. The risk of musculoskeletal conditions increased with both increasing pre\u2010pregnancy BMI and increasing parity. Compared to normal\u2010weight first\u2010time mothers, the highest risk was seen in obese women with &gt;2 births (HR 1.61 [95% confidence interval 1.41\u20131.83]). GWG of 10\u201315 kg was associated with the lowest risk of musculoskeletal conditions. Compared to women with no change in weight from preconception to 6 months after childbirth (\u00b11 BMI unit), increasing postpartum weight increased the risk of musculoskeletal conditions in normal\u2010weight and overweight women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings indicate that high pre\u2010pregnancy BMI increases the risk of degenerative musculoskeletal conditions. Low and high GWG, higher postpartum weight retention, and especially higher parity are associated with an increased risk. Prevention of being overweight before, during, and after pregnancy may reduce the risk of development of degenerative musculoskeletal conditions among mothers.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.39565","type":"journal-article","created":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T11:23:03Z","timestamp":1451388183000},"page":"1156-1164","source":"Crossref","is-referenced-by-count":32,"title":["Association of Pre\u2010Pregnancy Body Mass Index, Pregnancy\u2010Related Weight Changes, and Parity With the Risk of Developing Degenerative Musculoskeletal Conditions"],"prefix":"10.1002","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7637-3730","authenticated-orcid":false,"given":"Mette","family":"Bliddal","sequence":"first","affiliation":[{"name":"Odense University Hospital and University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Potteg\u00e5rd","sequence":"additional","affiliation":[{"name":"University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helene","family":"Kirkegaard","sequence":"additional","affiliation":[{"name":"University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rn","family":"Olsen","sequence":"additional","affiliation":[{"name":"Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan S.","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorkild I. 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