{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T10:00:54Z","timestamp":1791021654413,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,26]],"date-time":"2016-05-26T00:00:00Z","timestamp":1464220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007197","name":"USPHS","doi-asserted-by":"crossref","award":["DK046763"],"award-info":[{"award-number":["DK046763"]}],"id":[{"id":"10.13039\/100007197","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007197","name":"USPHS","doi-asserted-by":"crossref","award":["DK062413"],"award-info":[{"award-number":["DK062413"]}],"id":[{"id":"10.13039\/100007197","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007197","name":"USPHS","doi-asserted-by":"crossref","award":["AI078885"],"award-info":[{"award-number":["AI078885"]}],"id":[{"id":"10.13039\/100007197","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007197","name":"USPHS","doi-asserted-by":"crossref","award":["AI067068"],"award-info":[{"award-number":["AI067068"]}],"id":[{"id":"10.13039\/100007197","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007197","name":"USPHS","doi-asserted-by":"crossref","award":["U54DE023789-01"],"award-info":[{"award-number":["U54DE023789-01"]}],"id":[{"id":"10.13039\/100007197","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007197","name":"USPHS","doi-asserted-by":"crossref","award":["HS021747"],"award-info":[{"award-number":["HS021747"]}],"id":[{"id":"10.13039\/100007197","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NIH\/National Center for Advancing Translational Science (NCATS)","award":["UL1TR000124"],"award-info":[{"award-number":["UL1TR000124"]}]},{"name":"Helmsley Charitable Trust and the Crohn's and Colitis Foundation of America"},{"name":"Fineberg Foundation"},{"name":"Cedars-Sinai F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute"},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"crossref","award":["305479"],"award-info":[{"award-number":["305479"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare colonic microbial composition in systemic sclerosis (SSc) patients and healthy controls and to determine whether certain microbial genera are associated with gastrointestinal (GI) tract symptoms in patients with SSc.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Healthy controls were age\u2010 and sex\u2010matched (1:1) with adult SSc patients. Cecum and sigmoid mucosal lavage samples were obtained during colonoscopy. The microbiota in these samples were determined by Illumina HiSeq 2000 16S sequencing, and operational taxonomic units were selected. Linear discriminant analysis effect size was used to identify the genera that showed differential expression in SSc patients versus controls. Differential expression analysis for sequence count data was used to identify specific genera associated with GI tract symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 17 patients with SSc (88% female; median age 52.1 years), the mean\u2009\u00b1\u2009SD total GI Tract 2.0 score was 0.7\u2009\u00b1\u20090.6. Principal coordinate analysis illustrated significant differences in microbial communities in the cecum and sigmoid regions in SSc patients versus healthy controls (both\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.001). Similar to the findings in inflammatory disease states, SSc patients had decreased levels of commensal bacteria, such as\n                      <jats:italic>Faecalibacterium<\/jats:italic>\n                      and\n                      <jats:italic>Clostridium,<\/jats:italic>\n                      and increased levels of pathobiont bacteria, such as\n                      <jats:italic>Fusobacterium<\/jats:italic>\n                      and \u03b3\u2010\n                      <jats:italic>Proteobacteria<\/jats:italic>\n                      , compared with healthy controls.\n                      <jats:italic>Bifidobacterium<\/jats:italic>\n                      and\n                      <jats:italic>Lactobacillus<\/jats:italic>\n                      , which are typically reduced under conditions of inflammation, were also increased in abundance in patients with SSc. In SSc patients with moderate\/severe GI tract symptoms, the abundance of\n                      <jats:italic>Bacteroides fragilis<\/jats:italic>\n                      was decreased, and that of\n                      <jats:italic>Fusobacterium<\/jats:italic>\n                      was increased, compared with patients who had no or mild symptoms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrates a distinct colonic microbial signature in SSc patients compared with healthy controls. This unique ecologic change may perpetuate immunologic aberrations and contribute to clinical manifestations of SSc.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.39572","type":"journal-article","created":{"date-parts":[[2016,1,10]],"date-time":"2016-01-10T12:35:40Z","timestamp":1452429340000},"page":"1483-1492","source":"Crossref","is-referenced-by-count":121,"title":["Association of Systemic Sclerosis With a Unique Colonic Microbial Consortium"],"prefix":"10.1002","volume":"68","author":[{"given":"Elizabeth R.","family":"Volkmann","sequence":"first","affiliation":[{"name":"University of California, Los Angeles David Geffen School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Ling","family":"Chang","sequence":"additional","affiliation":[{"name":"University of California, Los Angeles David Geffen School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nashla","family":"Barroso","sequence":"additional","affiliation":[{"name":"University of California, Los Angeles David Geffen School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel E.","family":"Furst","sequence":"additional","affiliation":[{"name":"University of California, Los Angeles David Geffen School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J.","family":"Clements","sequence":"additional","affiliation":[{"name":"University of California, Los Angeles David Geffen School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan H.","family":"Gorn","sequence":"additional","affiliation":[{"name":"University of California, Los Angeles David Geffen School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bennett E.","family":"Roth","sequence":"additional","affiliation":[{"name":"University of California, Los Angeles David Geffen School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L.","family":"Conklin","sequence":"additional","affiliation":[{"name":"University of California, Los Angeles David Geffen School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terri","family":"Getzug","sequence":"additional","affiliation":[{"name":"University of California, Los Angeles David Geffen School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Borneman","sequence":"additional","affiliation":[{"name":"University of California Riverside"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dermot P. 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