{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T03:55:57Z","timestamp":1790222157219,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,26]],"date-time":"2016-05-26T00:00:00Z","timestamp":1464220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>C protein\u2013induced myositis (CIM) is a mouse model of polymyositis in which activated antigen\u2010specific CD8+ T cells injure the muscles. Animal models of autoimmunity that have been examined in the past for the effects of the type 1 cytokine interferon\u2010\u03b3 (IFN\u03b3) and the type 2 cytokine interleukin\u20104 (IL\u20104) are all mediated by pathogenic CD4+ T cells. In those models, the disruption of IFN\u03b3 leads to up\u2010regulation of IL\u201017A, exacerbating the disease with neutrophil infiltration into sites of inflammation. This study was undertaken to investigate the roles of IFN\u03b3 and IL\u20104, as well as IL\u201017A in the absence of IFN\u03b3, in CD8+ T cell\u2013mediated CIM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>IFN\u03b3<jats:sup>\u2212\/\u2212<\/jats:sup> mice, anti\u2013IL\u201017A antibody\u2013treated IFN\u03b3<jats:sup>\u2212\/\u2212<\/jats:sup> mice, IFN\u03b3<jats:sup>\u2212\/\u2212<\/jats:sup>IL\u201017A<jats:sup>\u2212\/\u2212<\/jats:sup> mice, IL\u20104<jats:sup>\u2212\/\u2212<\/jats:sup> mice, and wild\u2010type C57BL\/6 mice were immunized with skeletal muscle C protein fragments to induce CIM. Muscle tissue specimens were examined histologically.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>IFN\u03b3<jats:sup>\u2212\/\u2212<\/jats:sup> mice developed myositis at a higher incidence and with greater severity than wild\u2010type mice. Unlike wild\u2010type mice, IFN\u03b3<jats:sup>\u2212\/\u2212<\/jats:sup> mice had infiltration of neutrophils into the endomysial sites of the affected muscles. IFN\u03b3<jats:sup>\u2212\/\u2212<\/jats:sup> mice treated with anti\u2013IL\u201017A antibodies and IFN\u03b3<jats:sup>\u2212\/\u2212<\/jats:sup>IL\u201017A<jats:sup>\u2212\/\u2212<\/jats:sup> mice developed myositis with an incidence and severity comparable to those in IFN\u03b3<jats:sup>\u2212\/\u2212<\/jats:sup> mice and showed neutrophil infiltration similar to that in IFN\u03b3<jats:sup>\u2212\/\u2212<\/jats:sup> mice. IL\u20104<jats:sup>\u2212\/\u2212<\/jats:sup> mice developed CIM comparable to that in wild\u2010type mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings indicate that IFN\u03b3, but not IL\u20104, plays a suppressive role in the development of CIM. Unlike in CD4+ T cell\u2013mediated autoimmune disease models, IFN\u03b3 prevents factors other than IL\u201017A from exacerbating myositis and neutrophil infiltration in CD8+ T cell\u2013mediated CIM.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.39592","type":"journal-article","created":{"date-parts":[[2016,1,27]],"date-time":"2016-01-27T15:14:20Z","timestamp":1453907660000},"page":"1505-1510","source":"Crossref","is-referenced-by-count":10,"title":["Interferon\u2010\u03b3, but Not Interleukin\u20104, Suppresses Experimental Polymyositis"],"prefix":"10.1002","volume":"68","author":[{"given":"Yoko","family":"Yoshihashi\u2010Nakazato","sequence":"first","affiliation":[{"name":"Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimito","family":"Kawahata","sequence":"additional","affiliation":[{"name":"Tokyo Medical and Dental University, Graduate School of Medical and Dental 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