{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T02:09:54Z","timestamp":1791684594943,"version":"4.3.4"},"reference-count":53,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,6,24]],"date-time":"2016-06-24T00:00:00Z","timestamp":1466726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Endurance exercise demonstrates beneficial effects in polymyositis\/dermatomyositis (PM\/DM); however, the molecular effects of exercise on skeletal muscle are incompletely understood. We undertook this controlled pilot study to investigate the effects of a 12\u2010week endurance exercise training program on the molecular profile of skeletal muscle in patients with established PM\/DM compared to a nonexercised control group of patients with established PM\/DM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifteen patients (7 in the exercise group and 8 in the control group) with paired baseline and 12\u2010week follow\u2010up muscle biopsy samples were included. Messenger RNA expression profiling, mass spectrometry\u2013based quantitative proteomics, and immunohistochemical analyses were performed on muscle biopsy samples to determine molecular adaptations associated with changes in clinical measurements induced by endurance exercise.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to the control group, the exercise group improved in minutes of cycling time (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) and V<jats:sc>o<\/jats:sc><jats:sub>2<\/jats:sub> max (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The exercise group also had reduced disease activity (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) and reduced lactate levels at exhaustion (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Genes related to capillary growth, mitochondrial biogenesis, protein synthesis, cytoskeletal remodeling, and muscle hypertrophy were up\u2010regulated in the exercise group, while genes related to inflammation\/immune response and endoplasmic reticulum stress were down\u2010regulated. Mitochondrial pathways including the oxidative phosphorylation metabolic pathway were most affected by the endurance exercise, as demonstrated by proteomics analysis. The exercise group also showed a higher number of capillaries per mm<jats:sup>2<\/jats:sup> in follow\u2010up biopsy samples (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data indicate that endurance exercise in patients with established PM and DM may activate an aerobic phenotype and promote muscle growth and simultaneously suppress the inflammatory response in these patients\u2019 muscles, as supported by a combination of data on gene expression, proteomics, and capillary density in repeated muscle biopsies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.39624","type":"journal-article","created":{"date-parts":[[2016,2,11]],"date-time":"2016-02-11T09:20:46Z","timestamp":1455182446000},"page":"1738-1750","source":"Crossref","is-referenced-by-count":76,"title":["Endurance Exercise Improves Molecular Pathways of Aerobic Metabolism in Patients With Myositis"],"prefix":"10.1002","volume":"68","author":[{"given":"Li Alemo","family":"Munters","sequence":"first","affiliation":[{"name":"Vanderbilt University, Nashville, Tennessee, and Karolinska Institutet and Karolinska University Hospital Solna Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingela","family":"Loell","sequence":"additional","affiliation":[{"name":"Karolinska Institutet and Karolinska University Hospital Solna Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Ossipova","sequence":"additional","affiliation":[{"name":"Karolinska Institutet and Karolinska University Hospital Solna Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Raouf","sequence":"additional","affiliation":[{"name":"Karolinska Institutet and Karolinska University Hospital Solna Stockholm 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