{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T06:46:55Z","timestamp":1793774815225,"version":"4.6.1"},"reference-count":52,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,8,25]],"date-time":"2016-08-25T00:00:00Z","timestamp":1472083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,8,25]],"date-time":"2016-08-25T00:00:00Z","timestamp":1472083200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe the efficacy and safety of omalizumab, an anti\u2010IgE monoclonal antibody, in patients with refractory and\/or relapsing eosinophilic granulomatosis with polyangiitis (Churg\u2010Strauss) (EGPA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a nationwide retrospective study including EGPA patients who received omalizumab. Response was defined as the absence of asthma and\/or sinonasal exacerbations with a prednisone dosage of \u22647.5 mg\/day (complete response) or &gt;7.5 mg\/day (partial response).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seventeen patients (median age 45 years) received omalizumab for severe steroid\u2010dependent asthma (88%) and\/or sinonasal involvement (18%). After a median follow\u2010up of 22 months, 6 patients (35%) achieved a complete response, 5 patients (30%) achieved a partial response, and 6 patients (35%) had no improvement. The median Birmingham Vasculitis Activity Score decreased from 2.5 at baseline to 0.5 at 12 months. The median number of exacerbations per month decreased from 1 at baseline to 0 at 12 months, and the median forced expiratory volume in 1 second increased from 63% of the percent predicted at baseline to 85% of the percent predicted at 12 months. The median prednisone dosage decreased from 16 mg\/day at baseline to 11 mg\/day at 6 months and 9 mg\/day at 12 months. Omalizumab was discontinued in 8 patients (47%) during follow\u2010up, because of remission (12.5%), adverse event despite disease remission (12.5%), refractory disease (25%), or relapse (50%). Relapses included retrobulbar optic neuritis attributable to EGPA in 2 patients and severe asthma flare in 2 others.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The results of this study suggest that omalizumab may have a corticosteroid\u2010sparing effect in EGPA patients with asthmatic and\/or sinonasal manifestations, but reducing the corticosteroid dose may also increase the risk of severe EGPA flares, which raises the question of the safety of omalizumab in patients with EGPA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.39663","type":"journal-article","created":{"date-parts":[[2016,3,6]],"date-time":"2016-03-06T02:39:54Z","timestamp":1457231994000},"page":"2274-2282","source":"Crossref","is-referenced-by-count":92,"title":["Anti\u2010IgE Monoclonal Antibody (Omalizumab) in Refractory and Relapsing Eosinophilic Granulomatosis With Polyangiitis (Churg\u2010Strauss): Data on Seventeen Patients"],"prefix":"10.1002","volume":"68","author":[{"given":"Marie","family":"Jachiet","sequence":"first","affiliation":[{"name":"National Referral Center for Systemic and Autoimmune Diseases, H\u00f4pital Cochin, AP\u2010HP, and Universit\u00e9 Paris Descartes, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Samson","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire (CHU) de Dijon, Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Cottin","sequence":"additional","affiliation":[{"name":"H\u00f4pital Edouard Herriot Herriot, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Emmanuel","family":"Kahn","sequence":"additional","affiliation":[{"name":"H\u00f4pital Foch, Universit\u00e9 Versailles Saint\u2010Quentin en Yvelines Suresnes 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