{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:45:41Z","timestamp":1791859541008,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,8,25]],"date-time":"2016-08-25T00:00:00Z","timestamp":1472083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,8,25]],"date-time":"2016-08-25T00:00:00Z","timestamp":1472083200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"NIH (National Institute of Arthritis and Musculoskeletal and Skin Diseases [NIAMS]","award":["K23-AR-059677"],"award-info":[{"award-number":["K23-AR-059677"]}],"id":[{"id":"https:\/\/ror.org\/006zn3t30","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000069","name":"NIAMS","doi-asserted-by":"crossref","award":["K23-AR-059677"],"award-info":[{"award-number":["K23-AR-059677"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000069","name":"NIAMS","doi-asserted-by":"crossref","award":["NIH (NIAMS grant AR-047782)"],"award-info":[{"award-number":["NIH (NIAMS grant AR-047782)"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000069","name":"NIAMS","doi-asserted-by":"crossref","award":["AR-052403 and AR-049880"],"award-info":[{"award-number":["AR-052403 and AR-049880"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000069","name":"NIAMS","doi-asserted-by":"crossref","award":["K24-AR-055989 and R01-AR-056215"],"award-info":[{"award-number":["K24-AR-055989 and R01-AR-056215"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100006093","name":"Patient-Centered Outcomes Research Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100006093","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The FDA, and the NIH\/National Heart, Lung, and Blood Institute","id":[{"id":"https:\/\/ror.org\/012pb6c26","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Recent research showed an increased risk of high\u2010grade cervical dysplasia and cervical cancer associated with rheumatoid arthritis (RA). The purpose of this study was to examine whether this risk was associated with the use of biologic versus nonbiologic disease\u2010modifying antirheumatic drugs (DMARDs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We identified RA patients in the US Medicaid and commercial insurance databases (for the years 2000\u20132012) who were starting treatment with either a biologic or a nonbiologic DMARD. High\u2010grade cervical dysplasia or cervical cancer was identified with a validated claims\u2010based algorithm, and we assessed utilization of gynecologic procedures. To control for potential confounders, those starting therapy with a biologic DMARD were matched 1:1 to those starting therapy with a nonbiologic DMARD according to the propensity score (PS). Hazard ratios (HRs) and rate ratios (RRs) in the PS\u2010matched Medicaid and commercial insurance cohorts were pooled by an inverse variance\u2013weighted fixed\u2010effects model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 14,729 pairs of patients initiating biologic and nonbiologic DMARDs from the Medicaid cohort and 7,538 pairs from the commercial insurance cohort. During 73,389 person\u2010years of active treatment with either biologic or nonbiologic DMARDs, 95 cases of high\u2010grade cervical dysplasia or cervical cancer occurred in the 2 cohorts. The HR for high\u2010grade cervical dysplasia or cervical cancer associated with biologic DMARD use was 1.25 (95% confidence interval [95% CI] 0.78\u20132.01) in the Medicaid cohort and 1.63 (95% CI 0.62\u20134.27) in the commercial insurance cohort, with a pooled HR of 1.32 (95% CI 0.86\u20132.01). The rate of gynecologic procedures involving the uterine cervix was not different between the 2 groups (pooled RR 0.96 [95% CI 0.90\u20131.02]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Among women with RA, initiation of therapy with a biologic DMARD was associated with a numerically significant, but not statistically significant, increase in the risk of high\u2010grade cervical dysplasia or cervical cancer as compared to initiation of a nonbiologic DMARD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.39689","type":"journal-article","created":{"date-parts":[[2016,3,25]],"date-time":"2016-03-25T10:40:44Z","timestamp":1458902444000},"page":"2106-2113","source":"Crossref","is-referenced-by-count":28,"title":["Biologic Disease\u2010Modifying Antirheumatic Drugs and Risk of High\u2010Grade Cervical Dysplasia and Cervical Cancer in Rheumatoid Arthritis: A Cohort Study"],"prefix":"10.1002","volume":"68","author":[{"given":"Seoyoung C.","family":"Kim","sequence":"first","affiliation":[{"name":"Brigham and Women's Hospital Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Schneeweiss","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth W.","family":"Karlson","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey N.","family":"Katz","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Feldman","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel H.","family":"Solomon","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,25]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"GLOBOCAN 2012 v1.1: estimated cancer incidence mortality and prevalence worldwide in 2012. 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