{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:45:36Z","timestamp":1791859536273,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,8,25]],"date-time":"2016-08-25T00:00:00Z","timestamp":1472083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,8,25]],"date-time":"2016-08-25T00:00:00Z","timestamp":1472083200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"DFG","award":["SPP1468 programme Immunobone and CRC 1181 programme Checkpoints for Resolution of Inflammation"],"award-info":[{"award-number":["SPP1468 programme Immunobone and CRC 1181 programme Checkpoints for Resolution of Inflammation"]}]},{"name":"BMBF (project Metarthros)"},{"name":"The European Union (Seventh Framework Programme projects Marie Curie ITN Osteoimmune, EuroTEAM, and the Innovative Medicines Initiative project BTCure)","id":[{"id":"https:\/\/ror.org\/019af4n30","id-type":"ROR","asserted-by":"crossref"}]},{"name":"The CNPq (Ciencias sem Fronteiras)","award":["200175\/2014-9"],"award-info":[{"award-number":["200175\/2014-9"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To search for evidence of secondary osteoarthritis (OA) in patients with rheumatoid arthritis (RA) in a cross\u2010sectional and longitudinal setting, and to relate osteophyte formation to functional outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Anti\u2013citrullinated protein antibody (ACPA)\u2013positive RA patients underwent high\u2010resolution peripheral quantitative computed tomography of the hand. Cross\u2010sectional and longitudinal measurements were performed. The number and size (volume) of osteophytes as well as bone erosions were documented. The relationship of osteophytes to bone erosions and to demographic and disease\u2010specific data was evaluated by multiple logistic regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 202 ACPA\u2010positive RA patients were enrolled in the cross\u2010sectional part of the study, and a total of 77 ACPA\u2010positive RA patients were enrolled in the longitudinal analysis (interval of 1.5 years between baseline and follow\u2010up assessment). The mean\u2009\u00b1\u2009SD number of osteophytes per patient was 1.3\u2009\u00b1\u20092.3, and the mean\u2009\u00b1\u2009SD osteophyte volume per patient was 2.6\u2009\u00b1\u20094.9 mm\n                      <jats:sup>3<\/jats:sup>\n                      . The total number of erosions was significantly correlated with the total number of osteophytes (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), and the total volume of erosions was significantly correlated with the total volume of osteophytes (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Moreover, the number of osteophytes was related to age (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) and disease duration (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.001), while the volume of osteophytes was related to age (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.001), disease duration (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), and function as measured by the Health Assessment Questionnaire (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.013). Multivariate regression analyses showed an independent association between osteophytes and erosions. In the longitudinal analysis, the mean number (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.033) and volume (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) of osteophytes increased significantly in RA patients during their disease course.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Age, disease duration, and bone erosions are associated with osteophytes, indicating development of secondary OA in patients with RA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.39698","type":"journal-article","created":{"date-parts":[[2016,4,10]],"date-time":"2016-04-10T08:36:01Z","timestamp":1460277361000},"page":"2114-2121","source":"Crossref","is-referenced-by-count":43,"title":["Quantification and Impact of Secondary Osteoarthritis in Patients With Anti\u2013Citrullinated Protein Antibody\u2013Positive Rheumatoid Arthritis"],"prefix":"10.1002","volume":"68","author":[{"given":"Camille P.","family":"Figueiredo","sequence":"first","affiliation":[{"name":"University of Erlangen\u2013Nuremberg, Erlangen, Germany, and Universidade de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Simon","sequence":"additional","affiliation":[{"name":"University of Erlangen\u2013Nuremberg Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Englbrecht","sequence":"additional","affiliation":[{"name":"University of Erlangen\u2013Nuremberg Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Haschka","sequence":"additional","affiliation":[{"name":"University of Erlangen\u2013Nuremberg, Erlangen, Germany, and St. Vincent Hospital Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnd","family":"Kleyer","sequence":"additional","affiliation":[{"name":"University of Erlangen\u2013Nuremberg Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Bayat","sequence":"additional","affiliation":[{"name":"University of Erlangen\u2013Nuremberg Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Hueber","sequence":"additional","affiliation":[{"name":"University of Erlangen\u2013Nuremberg Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa M. R.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juergen","family":"Rech","sequence":"additional","affiliation":[{"name":"University of Erlangen\u2013Nuremberg Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Schett","sequence":"additional","affiliation":[{"name":"University of Erlangen\u2013Nuremberg Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1004965"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.121160"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.132423"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2012.153"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.135061"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.148395"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-201075"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38794"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27252"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.114512"},{"key":"e_1_2_6_12_1","first-page":"243","article-title":"Quantification of small joint space width, periarticular bone microstructure and erosions using high\u2010resolution peripheral quantitative computed tomography in rheumatoid arthritis","volume":"31","author":"Barnabe C","year":"2013","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205428"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27584"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380107"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230202"},{"key":"e_1_2_6_17_1","first-page":"1421","article-title":"Bone remodeling and osteophyte formation after remission of rheumatoid arthritis","volume":"16","author":"Cabral AR","year":"1989","journal-title":"J Rheumatol"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00194244"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201982"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24417"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.52.5.332"},{"key":"e_1_2_6_22_1","first-page":"1906","article-title":"Severity of disability and duration of disease in rheumatoid arthritis","volume":"19","author":"Leigh JP","year":"1992","journal-title":"J Rheumatol"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200012)43:12<2751::AID-ANR15>3.0.CO;2-6"},{"key":"e_1_2_6_24_1","first-page":"1241","article-title":"Percentile curve reference charts of physical function: rheumatoid arthritis population","volume":"22","author":"Lassere M","year":"1995","journal-title":"J Rheumatol"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1538"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/319516a0"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780281111"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/anr.1780320211"}],"container-title":["Arthritis &amp; 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