{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:48:27Z","timestamp":1790801307341,"version":"4.1.0"},"reference-count":61,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,9,28]],"date-time":"2016-09-28T00:00:00Z","timestamp":1475020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To identify nailfold videocapillaroscopic features and other clinical risk factors for new digital ulcers (DUs) during a 6\u2010month period in patients with systemic sclerosis (SSc).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this multicenter, prospective, observational cohort study, the videoCAPillaroscopy (CAP) study, we evaluated 623 patients with SSc from 59 centers (14 countries). Patients were stratified into 2 groups: a DU history group and a no DU history group. At enrollment, patients underwent detailed nailfold videocapillaroscopic evaluation and assessment of demographic characteristics, DU status, and clinical and SSc characteristics. Risk factors for developing new DUs were assessed using univariable and multivariable logistic regression (MLR) analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 468 patients in the DU history group (mean\u2009\u00b1\u2009SD age 54.0\u2009\u00b1\u200913.7 years), 79.5% were female, 59.8% had limited cutaneous SSc, and 22% developed a new DU during follow\u2010up. The strongest risk factors for new DUs identified by MLR in the DU history group included the mean number of capillaries per millimeter in the middle finger of the dominant hand, the number of DUs (categorized as 0, 1, 2, or \u22653), and the presence of critical digital ischemia. The receiver operating characteristic (ROC) of the area under the curve (AUC) of the final MLR model was 0.738 (95% confidence interval [95% CI] 0.681\u20130.795). Internal validation through bootstrap generated a ROC AUC of 0.633 (95% CI 0.510\u20130.756).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This international prospective study, which included detailed nailfold videocapillaroscopic evaluation and extensive clinical characterization of patients with SSc, identified the mean number of capillaries per millimeter in the middle finger of the dominant hand, the number of DUs at enrollment, and the presence of critical digital ischemia at enrollment as risk factors for the development of new DUs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.39718","type":"journal-article","created":{"date-parts":[[2016,4,25]],"date-time":"2016-04-25T20:22:48Z","timestamp":1461615768000},"page":"2527-2539","source":"Crossref","is-referenced-by-count":148,"title":["Nailfold Videocapillaroscopic Features and Other Clinical Risk Factors for Digital Ulcers in Systemic Sclerosis: A Multicenter, Prospective Cohort Study"],"prefix":"10.1002","volume":"68","author":[{"given":"Maurizio","family":"Cutolo","sequence":"first","affiliation":[{"name":"University of Genoa and IRCCS Azienda Ospedaliera Universitaria San Martino Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariane L.","family":"Herrick","sequence":"additional","affiliation":[{"name":"University of Manchester, Salford Royal NHS Foundation Trust, NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester NHS Foundation Trust and Manchester Academic Health Science Centre Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Distler","sequence":"additional","affiliation":[{"name":"University Hospital Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike O.","family":"Becker","sequence":"additional","affiliation":[{"name":"University Hospital, Zurich, Switzerland, and Charit\u00e9 University Hospital Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Beltran","sequence":"additional","affiliation":[{"name":"Hospital Universitario y Polit\u00e9cnico La Fe Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Carpentier","sequence":"additional","affiliation":[{"name":"La Tronche Hospital Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clodoveo","family":"Ferri","sequence":"additional","affiliation":[{"name":"University of Modena and Reggio Emilia Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Inan\u00e7","sequence":"additional","affiliation":[{"name":"Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panayiotis","family":"Vlachoyiannopoulos","sequence":"additional","affiliation":[{"name":"National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harbajan","family":"Chadha\u2010Boreham","sequence":"additional","affiliation":[{"name":"Actelion Pharmaceuticals Allschwil Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Cottreel","sequence":"additional","affiliation":[{"name":"Actelion Pharmaceuticals Allschwil Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Pfister","sequence":"additional","affiliation":[{"name":"Actelion Pharmaceuticals Allschwil Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"Actelion Pharmaceuticals Allschwil Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan V.","family":"Torres","sequence":"additional","affiliation":[{"name":"Syntax for Science Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Smith","sequence":"additional","affiliation":[{"name":"Ghent University Hospital and Ghent University Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the CAP Study Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.062901"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep105"},{"key":"e_1_2_8_4_1","first-page":"2423","article-title":"Natural history of ischemic digital ulcers in systemic sclerosis: single\u2010center retrospective longitudinal study","volume":"34","author":"Hachulla E","year":"2007","journal-title":"J Rheumatol"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.072686"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2010.104"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20342"},{"issue":"76","key":"e_1_2_8_8_1","first-page":"71","article-title":"Functional impairment of systemic scleroderma patients with digital ulcerations: results from the DUO Registry","volume":"31","author":"Guillevin L","year":"2013","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22468"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.094193"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009742.2013.780095"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.130900"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken482"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.096677"},{"key":"e_1_2_8_15_1","first-page":"1573","article-title":"Criteria for the classification of early systemic sclerosis","volume":"28","author":"LeRoy EC","year":"2001","journal-title":"J Rheumatol"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.136929"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38098"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200022"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24394"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.130528"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200780"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.132431"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket386"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.3233\/CH-141809"},{"issue":"91","key":"e_1_2_8_25_1","first-page":"S47","article-title":"An observational cohort study of patients with newly diagnosed digital ulcer disease secondary to systemic sclerosis registered in the EUSTAR database","volume":"33","author":"Brand M","year":"2015","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14367"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230510"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.079756"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.115568"},{"key":"e_1_2_8_30_1","first-page":"155","article-title":"Nailfold videocapillaroscopy assessment of microvascular damage in systemic sclerosis","volume":"27","author":"Cutolo M","year":"2000","journal-title":"J Rheumatol"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780030207"},{"key":"e_1_2_8_32_1","volume-title":"Statistical models for prognostication","author":"Steyerberg E","year":"2010"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20676"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780121405"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203301"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-4541-9"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2013.06.003"},{"issue":"76","key":"e_1_2_8_38_1","first-page":"115","article-title":"Capillaroscopic Skin Ulcers Risk Index (CSURI) calculated with different videocapillaroscopy devices: how its predictive values change","volume":"31","author":"Sebastiani M","year":"2013","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205897"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2007.06279.x"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22018"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/784947"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.087353"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24038"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket168"},{"issue":"76","key":"e_1_2_8_46_1","first-page":"103","article-title":"Nailfold capillaroscopy abnormalities as predictors of mortality in patients with systemic sclerosis","volume":"31","author":"Kayser C","year":"2013","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep447"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem190"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-015-8500-0"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.131284"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.120416"},{"key":"e_1_2_8_52_1","article-title":"Elucidating the burden of recurrent and chronic digital ulcers in systemic sclerosis: long\u2010term results from the DUO Registry","author":"Matucci\u2010Cerinic M","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"e_1_2_8_53_1","first-page":"841","article-title":"Computerized nailfold video capillaroscopy\u2014a new tool for assessment of Raynaud's phenomenon","volume":"32","author":"Anderson ME","year":"2005","journal-title":"J Rheumatol"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27543"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu533"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.120082"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12067"},{"issue":"62","key":"e_1_2_8_58_1","first-page":"S36","article-title":"Reliability of widefield capillary microscopy to measure nailfold capillary density in systemic sclerosis","volume":"28","author":"Hudson M","year":"2010","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-013-2460-7"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24333"},{"issue":"91","key":"e_1_2_8_61_1","first-page":"S127","article-title":"Predictive value of vascular disease biomarkers for digital ulcers in systemic sclerosis patients","volume":"33","author":"Silva I","year":"2015","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2680"}],"container-title":["Arthritis &amp; Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.39718","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.39718","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/art.39718","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.39718","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:13:26Z","timestamp":1759940006000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/art.39718"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,28]]},"references-count":61,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1002\/art.39718"],"URL":"https:\/\/doi.org\/10.1002\/art.39718","archive":["Portico"],"relation":{},"ISSN":["2326-5191","2326-5205"],"issn-type":[{"value":"2326-5191","type":"print"},{"value":"2326-5205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,28]]}}}