{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T12:40:46Z","timestamp":1771332046523,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,9,28]],"date-time":"2016-09-28T00:00:00Z","timestamp":1475020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine the potential of circulating cytokines and chemokines as biomarkers of cancer mortality risk in patients with rheumatoid arthritis (RA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Male participants in the Veterans Affairs RA registry were followed up from the time of enrollment until death or December 2013. Cytokines and chemokines were measured in banked serum obtained at the time of enrollment, using a bead\u2010based multiplex assay, and a previously developed cytokine score was calculated. Vital status and cause of death were determined through the National Death Index. Associations of cytokines with cancer mortality were examined using multivariable competing\u2010risks regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 1,190 men with RA, 60 cancer deaths (30 of which were attributable to lung cancer) occurred over 5,307 patient\u2010years of follow\u2010up. The patients had a mean age of 64.5 years, had established disease (median duration 8.7 years), were seropositive for rheumatoid factor (81%) or anti\u2013cyclic citrullinated peptide antibody (77%), and frequently had a history of smoking (82% current or former). Seven of 17 analytes examined were individually associated with cancer mortality. The cytokine score was associated with overall cancer (subhazard ratio [SHR] 1.42, 95% confidence interval [95% CI] 1.08\u20131.85) and lung cancer (SHR 1.86, 95% CI 1.57\u20132.19) mortality in multivariable analyses. Those in the highest quartile of cytokine scores had a &gt;2\u2010fold increased risk of overall cancer mortality (<jats:italic>P<\/jats:italic>\u2009=\u20090.039) and a 6\u2010fold increased risk of lung cancer mortality (<jats:italic>P<\/jats:italic>\u2009=\u20090.028) relative to the lowest quartile. A synergistic interaction between current smoking and high cytokine score was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Serum cytokines and chemokines are associated with cancer and lung cancer mortality in men with RA, independent of multiple factors including age, smoking status, and prevalent cancer.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.39735","type":"journal-article","created":{"date-parts":[[2016,4,25]],"date-time":"2016-04-25T20:22:49Z","timestamp":1461615769000},"page":"2394-2402","source":"Crossref","is-referenced-by-count":23,"title":["Associations of Circulating Cytokines and Chemokines With Cancer Mortality in Men With Rheumatoid Arthritis"],"prefix":"10.1002","volume":"68","author":[{"given":"Bryant R.","family":"England","sequence":"first","affiliation":[{"name":"Veterans Affairs Nebraska\u2212Western Iowa Health Care System and University of Nebraska Medical Center Omaha"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"Sokolove","sequence":"additional","affiliation":[{"name":"VA Palo Alto Health Care System and Stanford University Palo Alto California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William H.","family":"Robinson","sequence":"additional","affiliation":[{"name":"VA Palo Alto Health Care System and Stanford University Palo Alto California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffrey M.","family":"Thiele","sequence":"additional","affiliation":[{"name":"Veterans Affairs Nebraska\u2212Western Iowa Health Care System and University of Nebraska Medical Center Omaha"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Apar K.","family":"Ganti","sequence":"additional","affiliation":[{"name":"Veterans Affairs Nebraska\u2212Western Iowa Health Care System and University of Nebraska Medical Center Omaha"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harlan","family":"Sayles","sequence":"additional","affiliation":[{"name":"Veterans Affairs Nebraska\u2212Western Iowa Health Care System and University of Nebraska Medical Center Omaha"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5350-3934","authenticated-orcid":false,"given":"Kaleb","family":"Michaud","sequence":"additional","affiliation":[{"name":"Veterans Affairs Nebraska\u2212Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, and National Data Bank for Rheumatic Diseases Wichita Kansas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liron","family":"Caplan","sequence":"additional","affiliation":[{"name":"Denver VA Medical Center and University of Colorado Denver"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa A.","family":"Davis","sequence":"additional","affiliation":[{"name":"Denver VA Medical Center, University of Colorado, and Denver Health Medical Center Denver Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grant W.","family":"Cannon","sequence":"additional","affiliation":[{"name":"VA Salt Lake City Health Care System and University of Utah School of Medicine Salt Lake City"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Sauer","sequence":"additional","affiliation":[{"name":"VA Salt Lake City Health Care System and University of Utah School of Medicine Salt Lake City"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Namrata","family":"Singh","sequence":"additional","affiliation":[{"name":"Iowa City VA Health Care System and University of Iowa Iowa City"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4947-2741","authenticated-orcid":false,"given":"E.","family":"Blair Solow","sequence":"additional","affiliation":[{"name":"Dallas VA Medical Center and University of Texas Southwestern Medical Center Dallas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas M.","family":"Reimold","sequence":"additional","affiliation":[{"name":"Dallas VA Medical Center and University of Texas Southwestern Medical Center Dallas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gail S.","family":"Kerr","sequence":"additional","affiliation":[{"name":"Washington DC VA Medical Center and Georgetown\u2212Howard Universities Center for Clinical and Translational Science Washington DC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascale","family":"Schwab","sequence":"additional","affiliation":[{"name":"Portland VA Health Care System and Oregon Health and Sciences University Portland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josh F.","family":"Baker","sequence":"additional","affiliation":[{"name":"Philadelphia VA Medical Center and University of Pennsylvania Philadelphia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ted R.","family":"Mikuls","sequence":"additional","affiliation":[{"name":"Veterans Affairs Nebraska\u2212Western Iowa Health Care System and University of Nebraska Medical Center Omaha"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9,28]]},"reference":[{"issue":"51","key":"e_1_2_6_2_1","first-page":"S35","article-title":"Mortality in rheumatoid arthritis: 2008 update","volume":"5","author":"Sokka T","year":"2008","journal-title":"Clin Exp 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