{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:04:14Z","timestamp":1792782254191,"version":"4.5.0"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,9,29]],"date-time":"2016-09-29T00:00:00Z","timestamp":1475107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Dutch Organization for Scientific Research","id":[{"id":"https:\/\/ror.org\/04jsz6e67","id-type":"ROR","asserted-by":"crossref"}]},{"name":"FP7 HEALTH program","award":["FP7-HEALTH-F2-2012-305549"],"award-info":[{"award-number":["FP7-HEALTH-F2-2012-305549"]}]},{"name":"Dutch Arthritis Foundation","id":[{"id":"https:\/\/ror.org\/05dr3r825","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis & Rheumatology"],"published-print":{"date-parts":[[2016,11]]},"abstract":"\n Objective<\/jats:title>\n The use of magnetic resonance imaging (MRI)\u2013detected inflammation and joint damage in the diagnosis of rheumatoid arthritis is recommended by a European League Against Rheumatism imaging task force. This recommendation is based on the sensitivity of MRI and not on specificity. Knowledge of the prevalence of MRI\u2010detected features in symptom\u2010free persons, however, is pivotal when considering MRI for diagnostic purposes.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n From November 2013 to December 2014, 196 symptom\u2010free persons of different ages were recruited from the general population. Inclusion criteria were no history of inflammatory arthritis, no joint symptoms during the previous month, and no clinically detectable arthritis on physical examination. Contrast\u2010enhanced MRIs of the dominant metacarpophalangeal (MCP), wrist, and metatarsophalangeal (MTP) joints were obtained using a 1.5T scanner and scored by 2 readers for synovitis, bone marrow edema, tenosynovitis, and erosions. For analyses at the joint level, MRI\u2010detected inflammation was considered present if both readers scored the image as positive.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of 193 persons scanned (ages 19\u201389 years), only 28% had no single inflammatory feature and 22% had no erosions. Primarily low\u2010grade features were observed. All MRI features were positively correlated with age (\n P<\/jats:italic>\n \u2009<\u20090.001). Preferential locations for synovitis were MCP2, MCP3, the wrists, and MTP1. Bone marrow edema was frequently present in MCP3, the scaphoid, and MTP1. Tenosynovitis was infrequent, except for in the extensor carpi ulnaris. Preferential locations for erosions were MCP2, MCP3, MCP5, the distal ulna, MTP1, and MTP5. Tables with age\u2010, location\u2010, and inflammation type\u2013dependent frequencies were constructed. Simultaneous colocalized presence of synovitis, bone marrow edema, tenosynovitis, or erosions occurred.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n MRI\u2010detected inflammation and erosions are prevalent in symptom\u2010free persons from the general population, especially at older ages and at preferential locations.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/art.39749","type":"journal-article","created":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T06:48:19Z","timestamp":1464072499000},"page":"2593-2602","source":"Crossref","is-referenced-by-count":103,"title":["Magnetic Resonance Imaging\u2013Detected Features of Inflammation and Erosions in Symptom\u2010Free Persons From the General Population"],"prefix":"10.1002","volume":"68","author":[{"given":"L.","family":"Mangnus","sequence":"first","affiliation":[{"name":"Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. W.","family":"van Steenbergen","sequence":"additional","affiliation":[{"name":"Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Reijnierse","sequence":"additional","affiliation":[{"name":"Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. H. M.","family":"van der Helm\u2010van Mil","sequence":"additional","affiliation":[{"name":"Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-203158"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204005"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205208"},{"key":"e_1_2_7_5_1","first-page":"256","article-title":"Detection of erosions in the rheumatoid hand; a comparative study of multidetector computerized tomography versus magnetic resonance scanning","volume":"32","author":"Perry D","year":"2005","journal-title":"J Rheumatol"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38083"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2014-000005"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30396"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20135"},{"key":"e_1_2_7_10_1","first-page":"134","article-title":"How normal are the hands of normal controls? A study with dedicated magnetic resonance imaging","volume":"24","author":"Parodi M","year":"2006","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10963"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.090062"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009740903002257"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.131169"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205522"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.031773"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.068361"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.031831"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2005.03.010"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.110417"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0b013e31802ba28e"}],"container-title":["Arthritis & Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.39749","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.39749","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.39749","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T18:32:41Z","timestamp":1759948361000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/art.39749"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,29]]},"references-count":20,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1002\/art.39749"],"URL":"https:\/\/doi.org\/10.1002\/art.39749","archive":["Portico"],"relation":{},"ISSN":["2326-5191","2326-5205"],"issn-type":[{"value":"2326-5191","type":"print"},{"value":"2326-5205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,29]]}}}