{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:57:13Z","timestamp":1791212233967,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,9,28]],"date-time":"2016-09-28T00:00:00Z","timestamp":1475020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Dutch Arthritis Foundation (Reumafonds)"},{"name":"VICI grant from The Netherlands Organization for Scientific Research (NWO) and by a grant from the Dutch Arthritis Foundation (Reumafonds)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate whether seemingly healthy first\u2010degree relatives of patients with ankylosing spondylitis (AS) have clinical, laboratory, or imaging features of spondyloarthritis (SpA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>First\u2010degree relatives (ages 18\u201340 years) of HLA\u2013B27\u2013positive AS patients were included in the pre\u2010spondyloarthritis (Pre\u2010SpA) cohort, a prospective inception cohort study. Clinical, biologic, and imaging features were recorded. First\u2010degree relatives were classified according to several sets of SpA classification criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We report baseline features of 51 first\u2010degree relatives included in this study. Twenty\u2010nine (57%) had back pain, 2 (4%) had psoriasis, 1 (2%) had inflammatory bowel disease, and 1 (2%) had uveitis. Three (6%) had low\u2010grade sacroiliitis, 1 (2%) had cervical syndesmophytes on radiography, and 10 (20%) had bone marrow edema on magnetic resonance imaging of the sacroiliiac joints. Seventeen of 51 first\u2010degree relatives (33%) fulfilled SpA classification criteria: 7 (14%) fulfilled both Assessment of SpondyloArthritis international Society (ASAS) axial SpA and European Spondylarthropathy Study Group (ESSG) classification criteria, 6 (12%) fulfilled only ASAS axial SpA classification criteria, and 4 (8%) fulfilled only ESSG classification criteria; 3 (6%) also fulfilled the Amor criteria. None fulfilled other SpA classification criteria. First\u2010degree relatives fulfilling the ASAS axial SpA and\/or ESSG classification criteria had more frequent inflammatory back pain, had a higher level of disease activity, and had more psoriasis. No differences were found in parameters of inflammation, peripheral and extraarticular disease other than psoriasis, and HLA\u2013B27 positivity between those who did and those who did not fulfill the ASAS axial SpA and\/or ESSG classification criteria. Four first\u2010degree relatives (12%) who did not fulfill the ASAS axial SpA and\/or ESSG classification criteria had imaging abnormalities suggestive of SpA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A substantial proportion of seemingly healthy first\u2010degree relatives of HLA\u2013B27\u2013positive AS patients have clinical and\/or imaging abnormalities suggestive of SpA. Thirty\u2010three percent could be classified as having SpA. Further follow\u2010up will show which first\u2010degree relatives will develop clinically manifest SpA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.39766","type":"journal-article","created":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T06:49:11Z","timestamp":1464072551000},"page":"2444-2455","source":"Crossref","is-referenced-by-count":21,"title":["Clinical and Imaging Signs of Spondyloarthritis in First\u2010Degree Relatives of HLA\u2013B27\u2013Positive Ankylosing Spondylitis Patients: The Pre\u2010Spondyloarthritis (Pre\u2010SpA) Cohort Study"],"prefix":"10.1002","volume":"68","author":[{"given":"Maureen C.","family":"Turina","sequence":"first","affiliation":[{"name":"Academic Medical Center\/University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janneke J.","family":"de Winter","sequence":"additional","affiliation":[{"name":"Academic Medical Center\/University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacky E.","family":"Paramarta","sequence":"additional","affiliation":[{"name":"Academic Medical Center\/University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihaela","family":"Gamala","sequence":"additional","affiliation":[{"name":"Academic Medical Center\/University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nataliya","family":"Yeremenko","sequence":"additional","affiliation":[{"name":"Academic Medical Center\/University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marita N.","family":"Nabibux","sequence":"additional","affiliation":[{"name":"Tergooi Hospital Hilversum The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Landew\u00e9","sequence":"additional","affiliation":[{"name":"Academic Medical Center\/University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique L.","family":"Baeten","sequence":"additional","affiliation":[{"name":"Academic Medical Center\/University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60071-8"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-002-0237-4"},{"key":"e_1_2_7_4_1","first-page":"561","article-title":"Ankylosing spondylitis: how diagnostic and therapeutic delay have changed over the last six decades","volume":"30","author":"Salvadorini G","year":"2012","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205590"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.068734"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.110070"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201777"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23901"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23471"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2794"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2013.07.016"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000069"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.59.11.883"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21601"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009748409102661"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270301"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009748509165493"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.089599"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh577"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.140574"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204055"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.104018"},{"key":"e_1_2_7_24_1","first-page":"2286","article-title":"A new approach to defining disease status in ankylosing spondylitis: the Bath Ankylosing Spondylitis Disease Activity Index","volume":"21","author":"Garrett S","year":"1994","journal-title":"J Rheumatol"},{"key":"e_1_2_7_25_1","doi-asserted-by":"crossref","unstructured":"Lukas C Landewe R Sieper J Dougados M Davis J Braun J et al. 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