{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:24:12Z","timestamp":1793381052572,"version":"4.5.0"},"reference-count":44,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,11,28]],"date-time":"2016-11-28T00:00:00Z","timestamp":1480291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Relapsing polychondritis (RP) is a rare condition characterized by recurrent inflammation of cartilaginous tissue and systemic manifestations. Data on this disease remain scarce. This study was undertaken to describe patient characteristics and disease evolution, identify prognostic factors, and define different clinical phenotypes of RP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective study of 142 patients with RP who were seen between 2000 and 2012 in a single center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 142 patients, 86 (61%) were women. The mean\u2009\u00b1\u2009SD age at first symptoms was 43.5\u2009\u00b1\u200915 years. Patients had the following chondritis types: auricular (89%; n\u2009=\u2009127), nasal (63%; n\u2009=\u200989), laryngeal (43%; n\u2009=\u200961), tracheobronchial (22%; n\u2009=\u200932), and\/orcostochondritis (40%; n\u2009=\u200957). The main other manifestations were articular (69%; n\u2009=\u200998), ophthalmologic (56%; n\u2009=\u200980), audiovestibular (34%; n\u2009=\u200948), cardiac (27%; n\u2009=\u200938), and cutaneous (28%; n\u2009=\u200940). At a mean\u2009\u00b1\u2009SD followup of 13\u2009\u00b1\u20099 years, the 5\u2010 and 10\u2010year survival rates were 95\u2009\u00b1\u20092% and 91\u2009\u00b1\u20093%, respectively. Factors associated with death on multivariable analysis were male sex (<jats:italic>P<\/jats:italic>\u2009=\u20090.01), cardiac abnormalities (<jats:italic>P<\/jats:italic>\u2009=\u20090.03), and concomitant myelodysplastic syndrome (MDS) (<jats:italic>P<\/jats:italic>\u2009=\u20090.004) or another hematologic malignancy (<jats:italic>P<\/jats:italic>\u2009=\u20090.01). Cluster analysis revealed that separating patients into 3 groups was clinically relevant, thereby separating patients with associated MDS, those with tracheobronchial involvement, and those without the 2 features in terms of clinical characteristics, therapeutic management, and prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This large series of patients with definite RP revealed an improvement in survival as compared with previous studies. Factors associated with death were male sex, cardiac involvement, and concomitant hematologic malignancy. We identified 3 distinct phenotypes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.39790","type":"journal-article","created":{"date-parts":[[2016,6,22]],"date-time":"2016-06-22T19:12:47Z","timestamp":1466622767000},"page":"2992-3001","source":"Crossref","is-referenced-by-count":173,"title":["Relapsing Polychondritis Can Be Characterized by Three Different Clinical Phenotypes: Analysis of a Recent Series of 142 Patients"],"prefix":"10.1002","volume":"68","author":[{"given":"J\u00e9r\u00e9mie","family":"Dion","sequence":"first","affiliation":[{"name":"Universit\u00e9 Ren\u00e9 Descartes Paris V, AP\u2010HP, and Centre de r\u00e9f\u00e9rence maladies auto\u2010immunes et syst\u00e9miques rares, H\u00f4pital Cochin, AP\u2010HP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Costedoat\u2010Chalumeau","sequence":"additional","affiliation":[{"name":"Nathalie Costedoat-Chalumeau, MD, PhD: Universit\u00e9 Ren\u00e9 Descartes Paris V, AP-HP, Centre 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syst\u00e9miques rares, H\u00f4pital Piti\u00e9 Salp\u00eatri\u00e8re Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Dion","sequence":"additional","affiliation":[{"name":"INRA\u2010INSERM UR 1303 Ivry France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Franc\u00e8s","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Pierre et Marie Curie Paris VI, AP\u2010HP, and H\u00f4pital Tenon Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Charles","family":"Piette","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Pierre et Marie Curie Paris VI, AP\u2010HP, and Centre de r\u00e9f\u00e9rence maladies auto\u2010immunes et syst\u00e9miques rares, H\u00f4pital Piti\u00e9 Salp\u00eatri\u00e8re Paris 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