{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T01:19:55Z","timestamp":1793841595896,"version":"4.6.1"},"reference-count":15,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,11,28]],"date-time":"2016-11-28T00:00:00Z","timestamp":1480291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004089","name":"Krembil Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004089","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Biomarkers that can predict the development of psoriatic arthritis (PsA) in patients with psoriasis would be useful in clinical practice. The aim of this study was to assess whether CXCL10 could be a predictive biomarker of PsA prior to its onset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Psoriasis patients without arthritis were followed up prospectively and assessed annually for development of PsA by a rheumatologist. Patients in whom PsA developed were designated as converters, while those in whom PsA did not develop were termed nonconverters. Baseline serum concentrations of CXCL10 were measured by Luminex assay in 46 converters and 45 nonconverters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The level of CXCL10 was significantly higher in converters (median 493 pg\/ml [interquartile range (IQR) 356\u2013984]) than in nonconverters (median 371 pg\/ml [IQR 263\u2013578]; <jats:italic>P<\/jats:italic>\u2009=\u20090.005). In contrast, C\u2010reactive protein (CRP) levels were not significantly different between converters and nonconverters at baseline. CXCL10 was associated with conversion status after adjustment for age, sex, duration of psoriasis, and duration of follow\u2010up (odds ratio 1.3, 95% confidence interval 1.1\u20131.5, <jats:italic>P<\/jats:italic>\u2009=\u20090.004). In a subset of converters, the CXCL10 level was significantly higher at baseline (median 927.4 pg\/ml [IQR 547.6\u20131,243]) than after PsA diagnosis (491.5 pg\/ml [IQR 323.2\u2013607]; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001), while CRP levels were lower at baseline (26.6 \u03bcg\/ml [IQR 16.37\u201362.75]) than after PsA diagnosis (36.1 \u03bcg\/ml [IQR 14.74\u2013101.7]; <jats:italic>P<\/jats:italic>\u2009=\u20090.003). CXCL10 gene expression was increased 17.3\u2010fold in synovial fluid (SF) compared with blood from PsA patients (<jats:italic>P<\/jats:italic>\u2009=\u20090.01) and 44.3\u2010fold in the SF of PsA patients compared with the SF of patients with gout (<jats:italic>P<\/jats:italic>\u2009=\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CXCL10 may be involved in PsA pathogenesis and is a candidate predictive biomarker for PsA in patients with psoriasis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.39800","type":"journal-article","created":{"date-parts":[[2016,7,7]],"date-time":"2016-07-07T11:18:52Z","timestamp":1467890332000},"page":"2911-2916","source":"Crossref","is-referenced-by-count":85,"title":["Brief Report: CXCL10 Is a Possible Biomarker for the Development of Psoriatic Arthritis Among Patients With Psoriasis"],"prefix":"10.1002","volume":"68","author":[{"given":"Fatima","family":"Abji","sequence":"first","affiliation":[{"name":"University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remy A.","family":"Pollock","sequence":"additional","affiliation":[{"name":"University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Liang","sequence":"additional","affiliation":[{"name":"University of Waterloo Waterloo Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod","family":"Chandran","sequence":"additional","affiliation":[{"name":"University of Toronto and Toronto Western Hospital Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dafna D.","family":"Gladman","sequence":"additional","affiliation":[{"name":"University of Toronto and Toronto Western Hospital Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13210"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.07.023"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2011.150938"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.414"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2013.10.010"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21972"},{"key":"e_1_2_6_8_1","first-page":"S814","article-title":"The incidence and risk factors for PsA in patients with psoriasis: a prospective cohort study [abstract]","volume":"66","author":"Eder L","year":"2014","journal-title":"Arthritis Rheumatol"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2008.12.002"},{"key":"e_1_2_6_10_1","first-page":"22","article-title":"High values of Th1 (CXCL10) and Th2 (CCL2) chemokines in patients with psoriatic arthritis","volume":"27","author":"Antonelli A","year":"2009","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1545"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34330"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23512"},{"key":"e_1_2_6_14_1","first-page":"9","article-title":"C\u2010reactive protein in various disease conditions: an overview","volume":"4","author":"Ingle PV","year":"2011","journal-title":"Asian J Pharm Clin Res"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3780242"},{"key":"e_1_2_6_16_1","first-page":"e442","article-title":"Interferon \u03b3\u2010induced chemokines in psoriatic arthritis","volume":"165","author":"Devito A.","year":"2014","journal-title":"Clin Ter"}],"container-title":["Arthritis &amp; 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