{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T11:03:32Z","timestamp":1784718212997,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,12,28]],"date-time":"2016-12-28T00:00:00Z","timestamp":1482883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004328","name":"Genentech","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004328","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The Rituximab in ANCA\u2010Associated Vasculitis (RAVE) trial compared rituximab to cyclophosphamide as induction therapy for the treatment of antineutrophil cytoplasmic antibody (ANCA)\u2013associated vasculitis. We undertook the current study to determine whether known single\u2010nucleotide polymorphisms (SNPs) for Fc\u03b3 receptors (Fc\u03b3R) or cytochrome P450 (CYP) enzymes were associated with the response to treatment with rituximab and cyclophosphamide, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Functional SNPs for Fc\u03b3R (Fc\u03b3RIIa 519G&gt;A, Fc\u03b3RIIb 695T&gt;C, Fc\u03b3RIIIa 559T&gt;G) and CYP enzymes (CYP2B6 1459C&gt;T, CYP2C19 681G&gt;A) were analyzed by direct sequencing of polymerase chain reaction\u2013amplified genomic DNA. Each SNP was tested as a predictor of complete remission at 6 months or remission with continued prednisone administration using logistic regression and including the covariates of baseline Birmingham Vasculitis Activity Score for Wegener's Granulomatosis, ANCA type, and new versus relapsing disease. The associations of these SNPs with the secondary outcomes of time to complete remission, time to relapse, or time to B cell reconstitution were analyzed by Cox proportional hazard tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant associations were identified between complete remission and any Fc\u03b3R genotype in the rituximab group or any CYP genotype in the cyclophosphamide group. However, when the treatment groups were combined, an association was found between the 519AA genotype of Fc\u03b3RIIa and complete remission (<jats:italic>P<\/jats:italic>\u2009=\u20090.01). The 519AA genotype predicted complete remission (<jats:italic>P<\/jats:italic>\u2009=\u20090.006) and a shorter time to complete remission (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The finding that the homozygous Fc\u03b3RIIa 519AA variant was associated with complete response and a shorter time to complete response in the RAVE trial, independent of treatment type, implies that Fc\u03b3RIIa may be broadly involved in disease pathogenesis and response to therapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.39822","type":"journal-article","created":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T10:41:45Z","timestamp":1470220905000},"page":"169-175","source":"Crossref","is-referenced-by-count":23,"title":["The Pharmacogenomic Association of Fc\u03b3 Receptors and Cytochrome P450 Enzymes With Response to Rituximab or Cyclophosphamide Treatment in Antineutrophil Cytoplasmic Antibody\u2013Associated Vasculitis"],"prefix":"10.1002","volume":"69","author":[{"given":"Rodrigo","family":"Cartin\u2010Ceba","sequence":"first","affiliation":[{"name":"Mayo Clinic and Foundation, Rochester, Minnesota, and Scottsdale  Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divya","family":"Indrakanti","sequence":"additional","affiliation":[{"name":"Ohio State University Columbus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Specks","sequence":"additional","affiliation":[{"name":"Mayo Clinic and Foundation, Rochester, Minnesota, and Scottsdale  Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John H.","family":"Stone","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary S.","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cees G. 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William","family":"St.Clair","sequence":"additional","affiliation":[{"name":"Duke University Medical Center Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Seo","sequence":"additional","affiliation":[{"name":"Johns Hopkins University Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia K.","family":"Tchao","sequence":"additional","affiliation":[{"name":"Immune Tolerance Network San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R.","family":"Ytterberg","sequence":"additional","affiliation":[{"name":"Mayo Clinic and Foundation, Rochester, Minnesota, and Scottsdale  Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul G.","family":"Brunetta","sequence":"additional","affiliation":[{"name":"Genentech South San Francisco 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