{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T23:03:08Z","timestamp":1782514988708,"version":"3.54.5"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,12,28]],"date-time":"2016-12-28T00:00:00Z","timestamp":1482883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000341","name":"Arthritis Research UK","doi-asserted-by":"publisher","award":["20380 and special strategic award 18676"],"award-info":[{"award-number":["20380 and special strategic award 18676"]}],"id":[{"id":"10.13039\/501100000341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR\u201047785"],"award-info":[{"award-number":["AR\u201047785"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Osteoarthritis (OA) is a disease with a significant inflammatory component. The aim of this analysis was to determine the relationship between synovial fluid (SF) white blood cell (WBC) count and 2 parameters: disease severity and the reduction in knee pain after intraarticular (IA) steroid injection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Subjects with painful knee OA were recruited for participation in an open\u2010label study of IA steroid therapy. Information was obtained about knee pain using the Knee Injury and Osteoarthritis Outcome Score (KOOS) questionnaire, and a proportion of subjects underwent magnetic resonance imaging (MRI). Prior to injection with 80 mg methylprednisolone acetate, the index knee joint was aspirated and the fluid obtained was forwarded for assessment of SF WBC count.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Information on SF WBC count was available for 55 subjects. An increase in WBC count category (\u2264100, 101\u2013250, and 251\u20131,000 cells\/mm<jats:sup>3<\/jats:sup>) was associated with an increase in synovial tissue volume (<jats:italic>P<\/jats:italic>\u2009=\u20090.028) and with other MRI\u2010based measures of disease severity. Also, with each increase in SF WBC count category, there was a greater reduction in KOOS score after steroid injection (for WBC count of \u2264100 cells\/mm<jats:sup>3<\/jats:sup> [referent], mean\u2009\u00b1\u2009SD 12.5\u2009\u00b1\u200915.2; for WBC count of 101\u2013250 cells\/mm<jats:sup>3<\/jats:sup>, mean\u2009\u00b1\u2009SD 21.3\u2009\u00b1\u200920.6 [\u03b2 coefficient 0.279, <jats:italic>P<\/jats:italic>\u2009=\u20090.049]; for WBC count of 251\u20131,000 cells\/mm<jats:sup>3<\/jats:sup>, mean\u2009\u00b1\u2009SD 29.3\u2009\u00b1\u200915.2 [\u03b2 coefficient 0.320, <jats:italic>P<\/jats:italic>\u2009=\u20090.024]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although all participants in the analysis had SF WBC counts within the \u201cnormal\u201d range, total SF WBC count appears to be a biomarker for synovitis on MRI and may also predict response to antiinflammatory treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.39829","type":"journal-article","created":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T10:42:10Z","timestamp":1470220930000},"page":"103-107","source":"Crossref","is-referenced-by-count":33,"title":["Brief Report: Synovial Fluid White Blood Cell Count in Knee Osteoarthritis: Association With Structural Findings and Treatment Response"],"prefix":"10.1002","volume":"69","author":[{"given":"Paul S.","family":"McCabe","sequence":"first","affiliation":[{"name":"University of Manchester Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1574-9933","authenticated-orcid":false,"given":"Matthew J.","family":"Parkes","sequence":"additional","affiliation":[{"name":"University of Manchester and the Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasimah","family":"Maricar","sequence":"additional","affiliation":[{"name":"University of Manchester and the Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles E.","family":"Hutchinson","sequence":"additional","affiliation":[{"name":"University of Warwick Coventry UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Freemont","sequence":"additional","affiliation":[{"name":"University of Manchester Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terence W.","family":"O'Neill","sequence":"additional","affiliation":[{"name":"University of Manchester and the Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK, and the Salford Royal NHS Foundation Trust Salford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David T.","family":"Felson","sequence":"additional","affiliation":[{"name":"University of Manchester and the Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK, and Boston University School of Medicine Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2012.11.012"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2010.07.008"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2009.03.006"},{"key":"e_1_2_7_5_1","article-title":"Synovial tissue volume: a treatment target in knee osteoarthritis (OA)","author":"O'Neill TW","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)33125-X"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.50.2.101"},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/B978-0-323-09138-1.00031-0","volume-title":"Rheumatology","author":"Freemont AJ","year":"2015"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2012.08.005"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.2519\/jospt.1998.28.2.88"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.16.4.494"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mpdhp.2012.03.001"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2003.11.003"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem250"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/joca.2002.0861"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/19.4.212"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh021"}],"container-title":["Arthritis &amp; 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