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This study was undertaken to evaluate changes in HDL function and HDL\u2010associated proteins over 2 years of follow\u2010up in patients with early RA receiving either methotrexate (MTX) monotherapy, MTX\u2009+\u2009etanercept (ETN) combination therapy, or MTX\u2009+\u2009sulfasalazine (SSZ)\u2009+\u2009hydroxychloroquine (HCQ) triple therapy in the Treatment of Early Aggressive Rheumatoid Arthritis (TEAR) trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The antioxidant capacity of HDL, paraoxonase 1 (PON\u20101) activity, and levels of HDL\u2010associated haptoglobin (Hp), HDL\u2010associated apolipoprotein A\u2010I (Apo A\u2010I), and myeloperoxidase (MPO) were measured in 550 TEAR participants at 4 time points (time 0 [pretreatment] and at 24, 48, and 102 weeks of treatment). Repeated\u2010measures analysis using mixed\u2010effects linear models with an autoregressive covariate structure was performed to model the within\u2010subject covariance over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Mixed\u2010effects models, which were controlled for traditional CV risk factors, treatment regimen, prednisone use, and statin use, demonstrated significant associations between RA disease activity, measured using the Disease Activity Score in 28 joints, erythrocyte sedimentation rate, or C\u2010reactive protein level, and the profile of HDL function over time. Specifically, decreases in RA disease activity over time were associated with increases in PON\u20101 activity and levels of HDL\u2010associated Apo A\u2010I, and decreases in the HDL inflammatory index and levels of MPO and HDL\u2010associated Hp.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Reduced disease activity in patients with early RA treated with MTX monotherapy, MTX\u2009+\u2009ETN combination therapy, or MTX\u2009+\u2009SSZ\u2009+\u2009HCQ triple therapy in the TEAR trial was associated with improvements in the HDL function profile. Additional studies are warranted to evaluate abnormal HDL function as a potential mechanism and therapeutic target for CV risk in patients with RA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.39833","type":"journal-article","created":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T10:44:31Z","timestamp":1470221071000},"page":"46-57","source":"Crossref","is-referenced-by-count":55,"title":["Improvement of High\u2010Density Lipoprotein Function in Patients With Early Rheumatoid Arthritis Treated With Methotrexate Monotherapy or Combination Therapies in a Randomized Controlled Trial"],"prefix":"10.1002","volume":"69","author":[{"given":"Christina","family":"Charles\u2010Schoeman","sequence":"first","affiliation":[{"name":"University of California Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuen","family":"Yin Lee","sequence":"additional","affiliation":[{"name":"University of California Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ani","family":"Shahbazian","sequence":"additional","affiliation":[{"name":"University of California Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Wang","sequence":"additional","affiliation":[{"name":"University of California Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Elashoff","sequence":"additional","affiliation":[{"name":"University of California Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey R.","family":"Curtis","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Navarro\u2010Mill\u00e1n","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Yang","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lang","family":"Chen","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey S.","family":"Cofield","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry W.","family":"Moreland","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harold","family":"Paulus","sequence":"additional","affiliation":[{"name":"University of California Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"O'Dell","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center Omaha"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Bathon","sequence":"additional","affiliation":[{"name":"Columbia University New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"S. 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