{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T08:02:59Z","timestamp":1774339379086,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,1,28]],"date-time":"2017-01-28T00:00:00Z","timestamp":1485561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"AbbVie, France"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To validate the measurement properties and the detection performance of the FLARE\u2010RA questionnaire in a longitudinal prospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To validate the FLARE\u2010RA self\u2010administered questionnaire, we conducted a prospective trial in rheumatoid arthritis (RA) patients to document: 1) content and construct validity by factor analysis, convergent validity by Pearson's correlation with routine assessment of patient index data (Routine Assessment of Patient Index Data 3 [RAPID\u20103] questionnaire), RA Impact of Disease (RAID) score, Disease Activity Score in 28 joints (DAS28), and Health Assessment Questionnaire (HAQ), 2) reliability (intraclass correlation coefficient [ICC] and Bland\u2010Altman plot), and 3) feasibility of use. Patients were examined and questionnaires were collected at baseline and 3 months, and every week in between for RAPID\u20103.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We recruited 138 patients from 13 centers: 81.9% women, mean age 57.4 years, mean DAS28 2.9, mean C\u2010reactive protein level 6.2 mg\/liter, 84.4% rheumatoid factor positive, 78.0% anti\u2013citrullinated protein antibody positive, and 78.8% with erosive disease. At baseline, the mean\u2009\u00b1\u2009SD FLARE\u2010RA score was 2.3\u2009\u00b1\u20092.3. The content and construct validity of FLARE\u2010RA was good. A substantial floor effect, but no ceiling effect, was observed. Principal components analysis revealed 1 domain disentangled in 2 subdomains: physical and emotional. The FLARE\u2010RA total score was correlated with the DAS28 (r\u2009=\u20090.63, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), RAID (r\u2009=\u20090.80, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), RAPID\u20103 (r\u2009=\u20090.77, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and HAQ (r\u2009=\u20090.53, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The ICC for reliability was 0.94 (95% confidence interval 0.92\u20130.96).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The FLARE\u2010RA self\u2010administered questionnaire represents a valid and valuable instrument to detect RA flare between visits to the physician.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.39850","type":"journal-article","created":{"date-parts":[[2016,9,16]],"date-time":"2016-09-16T16:06:46Z","timestamp":1474042006000},"page":"309-319","source":"Crossref","is-referenced-by-count":38,"title":["Validation of FLARE\u2010RA, a Self\u2010Administered Tool to Detect Recent or Current Rheumatoid Arthritis Flare"],"prefix":"10.1002","volume":"69","author":[{"given":"Bruno","family":"Fautrel","sequence":"first","affiliation":[{"name":"Universit\u00e9 Pierre et Marie Curie Paris 6, UFR de M\u00e9decine and AP\u2010HP, GH Piti\u00e9 Salp\u00eatri\u00e8re, Service de Rhumatologie Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Morel","sequence":"additional","affiliation":[{"name":"CHU Lapeyronie, D\u00e9partement de Rhumatologie Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Marie","family":"Berthelot","sequence":"additional","affiliation":[{"name":"INSERM ERI 7 (EA 3822) Centre Hospitalo\u2010Universitaire de Nantes, H\u00f4tel\u2010Dieu, Service de Rhumatologie Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnaud","family":"Constantin","sequence":"additional","affiliation":[{"name":"Paul Sabatier Toulouse III University, Centre de Rhumatologie, H\u00f4pital Purpan and UMR 1043, INSERM\/UPS\/CNRS, H\u00f4pital Purpan Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"De Bandt","sequence":"additional","affiliation":[{"name":"Centre Hospitalier La Meynard, Service de Rhumatologie Fort de France France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Gaudin","sequence":"additional","affiliation":[{"name":"H\u00f4pital Sud A. Michallon Grenoble France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Francis","family":"Maillefert","sequence":"additional","affiliation":[{"name":"Centre Hospitalo\u2010Universitaire du Dijon, H\u00f4pital du Bocage, Service de Rhumatologie Dijon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Meyer","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Denis Diderot Paris 5, UFR de M\u00e9decine and AP\u2010HP, GH Bichat, Service de Rhumatologie Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thao","family":"Pham","sequence":"additional","affiliation":[{"name":"CHU Sainte\u2010Marguerite, Department of Rheumatology Marseilles France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Saraux","sequence":"additional","affiliation":[{"name":"Centre Hospitalo\u2010Universitaire de Brest, H\u00f4pital de la Cavale Blanche, Service de Rhumatologie, and EA 2216, INSERM ESPRI, ERI29 Universit\u00e9 Bretagne Occidentale Brest France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Solau\u2010Gervais","sequence":"additional","affiliation":[{"name":"CHU de Poitiers Poitiers France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Vittecoq","sequence":"additional","affiliation":[{"name":"Rouen University Hospital Department of Rheumatology and INSERM U905 (IFRMP 23), University of Rouen Rouen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Wendling","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Franche\u2010Comt\u00e9 EA4266, Agents pathog\u00e8nes et Inflammation and Centre Hospitalo\u2010Universitaire de Besan\u00e7on, H\u00f4pital Jean Minjoz, Service de Rhumatologie Besan\u00e7on France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2010Line","family":"Erpelding","sequence":"additional","affiliation":[{"name":"INSERM CIC\u2010EC 1433, University Hospital Nancy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis","family":"Guillemin","sequence":"additional","affiliation":[{"name":"INSERM CIC\u2010EC 1433, University Hospital and Universit\u00e9 de Lorraine, Universit\u00e9 Paris Descartes, EA 4360 APEMAC Nancy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of the STPR Group of the French Society of Rheumatology","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,1,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204573"},{"key":"e_1_2_6_3_1","article-title":"Impact of a nurse\u2010led programme on comorbidity management and impact of a patient self\u2010assessment of disease activity on the management of rheumatoid arthritis: results of a prospective, multicentre, randomised, controlled trial (COMEDRA)","author":"Dougados M","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2014.05.002"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27584"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204020"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.090369"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.110401"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.110400"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-201201"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2011.150656"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.131252"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2008.12.002"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61811-X"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380107"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20350"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20066"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20481"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20178"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(93)90142-N"},{"key":"e_1_2_6_21_1","first-page":"198","article-title":"The OMERACT filter for Outcome Measures in Rheumatology","volume":"25","author":"Boers M","year":"1998","journal-title":"J Rheumatol"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2006.02.021"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-10-22"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-10-82"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10824"},{"key":"e_1_2_6_27_1","first-page":"789","article-title":"The dimensions of health outcomes: the health assessment questionnaire, disability and pain scales","volume":"9","author":"Fries JF","year":"1982","journal-title":"J Rheumatol"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.142901"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02289447"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-004-1260-6"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02296272"},{"key":"e_1_2_6_32_1","unstructured":"AndrichD DouglasD.Reliability: distinctions between item consistency and subject separation with the simple logistic model [poster]. Presented at the Annual Meeting of the American Educational Research Association;1977; New York."},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-007-9184-6"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq455"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.081430"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/39.9.990"},{"issue":"1","key":"e_1_2_6_37_1","first-page":"75","article-title":"RCT of patient\u2010initiated review versus regular physician\u2010initiated follow\u2010up in rheumatoid arthritis, extended to 6 years [abstract]","volume":"63","author":"Kirwan J","year":"2004","journal-title":"Ann Rheum Dis"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38265.493773.8F"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204016"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.121491"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2008.11.009"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq060"}],"container-title":["Arthritis &amp; Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.39850","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.39850","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.39850","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T11:57:00Z","timestamp":1759924620000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/art.39850"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,28]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1002\/art.39850"],"URL":"https:\/\/doi.org\/10.1002\/art.39850","archive":["Portico"],"relation":{},"ISSN":["2326-5191","2326-5205"],"issn-type":[{"value":"2326-5191","type":"print"},{"value":"2326-5205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,28]]}}}